Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy

doi:10.1503/jpn.210084

PSYCH OpenIR

	Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy
	Gao, Jian 1,2,3; Yang, Xiangyun 1,2,3; Chen, Xiongying 1,2,3; Liu, Rui 1,2,3; Wang, Pengchong 1,2,3; Meng, Fanqiang 1,2,3; Li, Zhanjiang 1,2,3; Zhou, Yuan 1,2,4,5,6
通讯作者	Li, Zhanjiang(lizhj8@ccmu.edu.cn) ; Zhou, Yuan(zhouyuan@psych.ac.cn)
摘要	Background: Cognitive behavioural therapy (CBT) is considered an effective first-line treatment for obsessive-compulsive disorder (OCD). However, the neural basis of CBT for OCD has not yet been elucidated. The role of the amygdala in OCD and its functional coupling with the cerebral cortex have received increasing attention, and may provide new understanding of the neural basis of CBT for OCD. Methods: We acquired baseline resting-state functional MRI (fMRI) scans from 45 unmedicated patients with OCD and 40 healthy controls; we then acquired another wave of resting-state fMRI scans from the patients with OCD after 12 weeks of CBT. We performed seed-based resting-state functional connectivity analyses of the amygdala subregions to examine changes in patients with OCD as a result of CBT. Results: Compared to healthy controls, patients with OCD showed significantly increased resting-state functional connectivity at baseline between the left basolateral amygdala and the right middle frontal gyrus, and between the superficial amygdala and the right cuneus. In patients with OCD who responded to CBT, we found decreased resting-state functional connectivity after CBT between the amygdala subregions and the visual association cortices and increased resting-state functional connectivity between the amygdala subregions and the right inferior parietal lobe. Furthermore, these changes in resting-state functional connectivity were positively associated with changes in scores on the compulsion or obsession subscales of the Yale-Brown Obsessive-Compulsive Scale. Limitations: Because of the lack of a second scan for healthy controls after 12 weeks, our results may have been confounded by other variables. Conclusion: Our findings yield insights into the pathophysiology of OCD; they also reveal the potential neural changes elicited by CBT, and thus have implications for guiding effective treatment strategies with CBT for OCD.
	2021-11-16
语种	英语
DOI	10.1503/jpn.210084
发表期刊	JOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN	1180-4882
卷号	46 期号:6 页码:E628-E638
收录类别	SCI
资助项目	National Natural Science Foundation of China[81271493] ; Beijing Natural Science Foundation[7122082] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[XMLX202129]
出版者	CMA-CANADIAN MEDICAL ASSOC
WOS关键词	BASOLATERAL AMYGDALA ; NEURAL PREDICTORS ; CORTEX ; PERSONALITY ; NETWORKS ; METAANALYSIS ; DIMENSIONS ; ACTIVATION ; MECHANISMS ; SCALE
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Neurosciences ; Psychiatry
WOS记录号	WOS:000719546100001
资助机构	National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/41231
通讯作者	Li, Zhanjiang; Zhou, Yuan
作者单位	1.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 3.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China 4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Gao, Jian,Yang, Xiangyun,Chen, Xiongying,et al. Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2021,46(6):E628-E638.
APA	Gao, Jian.,Yang, Xiangyun.,Chen, Xiongying.,Liu, Rui.,Wang, Pengchong.,...&Zhou, Yuan.(2021).Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,46(6),E628-E638.
MLA	Gao, Jian,et al."Resting-state functional connectivity of the amygdala subregions in unmedicated patients with obsessive-compulsive disorder before and after cognitive behavioural therapy".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 46.6(2021):E628-E638.