其他摘要 | In recent years, spinal cord magnetic resonance imaging technology has developed rapidly. Due to the important physiological function of the spinal cord, resting functional magnetic resonance imaging technology of the spinal cord has great application prospects in basic research and clinic. However, compared with the brain, the spinal cord's physiological structure and surrounding tissue environment are more complex, so the imaging is more vulnerable to physiological noise, which poses a great challenge to the test-retest reliability of the experimental results. Verifying the test-retest reliability of the spinal cord resting一state functional network is very important to the credibility of basic research results. It is also a prerequisite for the application of spinal cord magnetic resonance imaging technology in the clinic. There have been many studies on test-retest reliability in the brain network. However, at present, there is no research on the test-retest reliability of magnetic resonance structural images of the spinal cord. There are few studies on the test-retest reliability of the resting functional network of the spinal cord. Some problems include the small number of subjects (about 10), short scanning interval
(within 1h), and limited analysis methods. Because of this situation, this study collected the spinal cord structure and functional image data through two scans at an interval of two weeks to further study the test-retest reliability of spinal cord structure imaging and spinal cord resting functional network.
In this study, through two scans of magnetic resonance structural images of the spinal cord, taking the cross一sectional area as the structural characteristics of the spinal cord, it is proved that the results of magnetic resonance structural imaging of the spinal cord have good test-retest reliability, which is similar to the results obtained by predecessors in the brain.
In this study, two methods based on seed point and frequency domain analysis were used to process the pretreated spinal cord resting functional image data, and then to study the test-retest reliability of subjects scanning spinal cord resting functional network every two weeks. Using the seed point-based method, we found that the functional connections within the dorsal and ventral angles were generally repeatable, and the functional connections between the dorsal and ventral angles were generally repeatable. Using the method of frequency domain analysis, we take ALFF and fALFF as indicators and find that ALFF and fALFF indicators show a general degree of test-retest reliability.
By comparing the data before and after preprocessing, it is found that whether using the method based on seed point or frequency domain analysis, the test-retest reliability results obtained from the data analysis after preprocessing are significantly greater than those before preprocessing, which proves that the preprocessing process adopted in this experiment effectively reduces the noise and improves the test-retest reliability of the resting functional network of the spinal cord.
To sum up, this experiment proves that, similar to the brain structure, the structural image of the spinal cord has good test-retest reliability; After proper pretreatment, the test-retest reliability of the resting functional network of the spinal cord can also approach or reach the level of the brain network. |
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