Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder

doi:10.1038/s41398-021-01754-4

PSYCH OpenIR

	Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder
	Cui, Jian 1,2; Wang, Yun 1,2; Liu, Rui 1,2; Chen, Xiongying 1,2; Zhang, Zhifang 1,2; Feng, Yuan 1,2,3; Zhou, Jingjing 1,2; Zhou, Yuan 1,2,4,5; Wang, Gang 1,2,3
通讯作者	Zhou, Yuan(zhouyuan@psych.ac.cn) ; Wang, Gang(gangwangdoc@ccmu.edu.cn)
摘要	Antidepressants are often the first-line medications prescribed for patients with major depressive disorder (MDD). Given the critical role of the default mode network (DMN) in the physiopathology of MDD, the current study aimed to investigate the effects of antidepressants on the resting-state functional connectivity (rsFC) within and between the DMN subsystems. We collected restingstate functional magnetic resonance imaging (rs-fMRI) data from 36 unmedicated MDD patients at baseline and after escitalopram treatment for 12 weeks. The rs-fMRI data were also collected from 61 matched healthy controls at the time point with the same interval. Then, we decomposed the DMN into three subsystems based on a template from previous studies and computed the rsFC within and between the three subsystems. Finally, repeated measures analysis of covariance was conducted to identify the main effect of group and time and their interaction effect. We found that the significantly reduced within-subsystem rsFC in the DMN core subsystem in patients with MDD at baseline was increased after escitalopram treatment and became comparable with that in the healthy controls, whereas the reduced within-subsystem rsFC persisted in the DMN dorsal medial prefrontal cortex (dMPFC) and medial temporal subsystems in patients with MDD following escitalopram treatment. In addition, the reduced between-subsystem rsFC between the core and dMPFC subsystem showed a similar trend of change after treatment in patients with MDD. Moreover, our main results were confirmed using the DMN regions from another brain atlas. In the current study, we found different effects of escitalopram on the rsFC of the DMN subsystems. These findings deepened our understanding of the neuronal basis of antidepressants' effect on brain function in patients with MDD. The trial name: appropriate technology study of MDD diagnosis and treatment based on objective indicators and measurement. URL: http://www.chictr.org.cn/showproj.aspx?proj=21377.
	2021-12-13
语种	英语
DOI	10.1038/s41398-021-01754-4
发表期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
卷号	11 期号:1 页码:11
收录类别	SCI
资助项目	National Key Research & Development Program of China[2016YFC1307200] ; National Natural Science Foundation of China[82071531] ; National Natural Science Foundation of China[81901372] ; National Natural Science Foundation of China[81901368] ; Capital's Funds for Health Improvement and Research[2020-4-2125] ; Scientific Research Common Program of Beijing Municipal Commission of Education[KM202010025010]
出版者	SPRINGERNATURE
WOS关键词	PRESCRIPTION PATTERN ; TREATMENT RESPONSE ; CINGULATE CORTEX ; BRAIN ; MODULATION ; SCALE ; 1ST-EPISODE ; ADOLESCENTS ; MEMORY ; FMRI
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000729797000004
资助机构	National Key Research & Development Program of China ; National Natural Science Foundation of China ; Capital's Funds for Health Improvement and Research ; Scientific Research Common Program of Beijing Municipal Commission of Education
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/41396
通讯作者	Zhou, Yuan; Wang, Gang
作者单位	1.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing Anding Hosp, Beijing 100088, Peoples R China 3.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China 4.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cui, Jian,Wang, Yun,Liu, Rui,et al. Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder[J]. TRANSLATIONAL PSYCHIATRY,2021,11(1):11.
APA	Cui, Jian.,Wang, Yun.,Liu, Rui.,Chen, Xiongying.,Zhang, Zhifang.,...&Wang, Gang.(2021).Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.TRANSLATIONAL PSYCHIATRY,11(1),11.
MLA	Cui, Jian,et al."Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder".TRANSLATIONAL PSYCHIATRY 11.1(2021):11.