Institutional Repository of Key Laboratory of Mental Health, CAS
Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups | |
Clausen, Ashley N.1,2,3; Fercho, Kelene A.6,10,41,57; Monsour, Molly2; Disner, Seth6,27,53; Salminen, Lauren66; Haswell, Courtney C.1,2; Rubright, Emily Clarke1,2; Watts, Amanda A.1,2; Buckley, M. Nicole1,2; Maron-Katz, Adi21; Sierk, Anika60; Manthey, Antje60; Suarez-Jimenez, Benjamin12,54; Olatunji, Bunmi O.34; Averill, Christopher L.11,30; Hofmann, David48; Veltman, Dick J.24; Olson, Elizabeth A.45,51; Li, Gen32,49; Forster, Gina L.5,41; Walter, Henrik60; Fitzgerald, Jacklynn50; Theberge, Jean15,29,46; Simons, Jeffrey S.6,57; Bomyea, Jessica A.59,63; Frijling, Jessie L.23; Krystal, John H.11,30; Baker, Justin T.47; Phan, K. Luan18; Ressler, Kerry26,42; Han, Laura K. M.25; Nawijn, Laura23,24; Lebois, Lauren A. M.26,42; Schmaall, Lianne9,55; Densmore, Maria29; Shenton, Martha E.26,28,37,56; van Zuiden, Mirjam23; Stein, Murray58,59; Fani, Negar20; Simons, Raluca M.6,33; Neufeld, Richard W. J.16,29,31,65; Lanius, Ruth16,29; van Rooij, Sanne20; Koch, Saskia B. J.23,44; Bonomo, Serena54; Jovanovic, Tanja19; DeRoon-Cassini, Terri52; Ely, Timothy D.20; Magnotta, Vincent A.38,39,40; He, Xiaofu12,54; Abdallah, Chadi G.11,30,67,68; Etkin, Amit21,64; Schmahl, Christian35; Larson, Christine62; Rosso, Isabelle M.45,51; Blackford, Jennifer Urbano22,36; Stevens, Jennifer S.20; Daniels, Judith K.61; Herzog, Julia35; Kaufman, Milissa L.43; Olff, Miranda4,23; Davidson, Richard J.7; Sponheim, Scott R.27,53; Mueller, Sven C.14,17; Straube, Thomas48; Zhu, Xi12,54; Neria, Yuval12,54; Baugh, Lee A.6,41,57; Cole, James H.8,13; Thompson, Paul M.66; Morey, Rajendra A.1,2,3,4,25 | |
第一作者 | Clausen, Ashley N. |
通讯作者邮箱 | ashley.n.clausen@gmail.com, ashley.clausen@sclhealth.org |
心理所单位排序 | 1 |
摘要 | Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA-PGC PTSD sites underwent T1-weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel-wise (brainageR) and region-of-interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age - chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three-way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age-related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan. |
关键词 | aging machine learning mega-analysis neuroimaging posttraumatic stress disorder trauma |
2021-12-14 | |
语种 | 英语 |
DOI | 10.1002/brb3.2413 |
发表期刊 | BRAIN AND BEHAVIOR |
ISSN | 2162-3279 |
页码 | 14 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Academic Medical Center Research Council ; Center for Brain and Behavior Research Pilot Grant ; National Center for Advancing Translational Sciences ; Department of Veterans Affairs RRD ; Canadian Institute for Military and Veteran Health Research ; National Center for Research Resources[CX001600] ; National Institutes of Health[K01MH122774] ; National Institutes of Health[R01 MH106574] ; Brain and Behavior Research Foundation[07040] ; VA Career Development Award ; National Institute on Alcohol Abuse and Alcoholism ; South Dakota Governor's Research Center Grant ; National Institute of Mental Health[F31MH113271] ; National Institute of Mental Health[K23MH112873] ; National Institute of Mental Health[R01-MH043454] ; National Institute of Mental Health[T32MH018931] ; National Institute of Mental Health[T32MH13043] ; Trauma Scholars Fund ; NIH from the Big Data to Knowledge (BD2K) program[U54 EB020403] ; German Research Society ; U.S. Department of Defense[W81XWH-10-1-0925] ; U.S. Department of Defense[W81XWH082-0159] ; NHMRC Career Development Fellowship ; Deutsche Forschungsgemeinschaft[DA1222/4-1] ; Deutsche Forschungsgemeinschaft[SFB/TRR 58] ; Deutsche Forschungsgemeinschaft[WA1539/8-2] ; U.S. Department of Veterans Affairs ; Barlow Family Fund ; Veterans Affairs Merit Review Program ; Institute of Neurosciences, Mental Health and Addiction ; German Federal Ministry of Education and Research ; Congressionally Directed Medical Research Programs[W81XWH08-2-0038] ; Kasparian Fund ; Netherlands organization for Health Research and Development ; MRC/UKRI Innovation Fellowship ; VISN6 MIRECC ; Bijzonder Onderzoeksfonds UGent ; Anonymous Women's Health Fund |
出版者 | WILEY |
WOS关键词 | CHILDHOOD TRAUMA ; DEPRESSION ; ANXIETY ; SCHIZOPHRENIA ; PREDICTION ; MATURITY ; VALIDITY ; VOLUME |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000730010700001 |
资助机构 | Academic Medical Center Research Council ; Center for Brain and Behavior Research Pilot Grant ; National Center for Advancing Translational Sciences ; Department of Veterans Affairs RRD ; Canadian Institute for Military and Veteran Health Research ; National Center for Research Resources ; National Institutes of Health ; Brain and Behavior Research Foundation ; VA Career Development Award ; National Institute on Alcohol Abuse and Alcoholism ; South Dakota Governor's Research Center Grant ; National Institute of Mental Health ; Trauma Scholars Fund ; NIH from the Big Data to Knowledge (BD2K) program ; German Research Society ; U.S. Department of Defense ; NHMRC Career Development Fellowship ; Deutsche Forschungsgemeinschaft ; U.S. Department of Veterans Affairs ; Barlow Family Fund ; Veterans Affairs Merit Review Program ; Institute of Neurosciences, Mental Health and Addiction ; German Federal Ministry of Education and Research ; Congressionally Directed Medical Research Programs ; Kasparian Fund ; Netherlands organization for Health Research and Development ; MRC/UKRI Innovation Fellowship ; VISN6 MIRECC ; Bijzonder Onderzoeksfonds UGent ; Anonymous Women's Health Fund |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/41401 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Clausen, Ashley N. |
作者单位 | 1.VA Mid Atlantic Mental Illness Res Educ & Clin Ct, Durham, NC 27705 USA 2.Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA 3.Kansas City VA Med Ctr, Kansas City, MO USA 4.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands 5.Univ Otago, Brain Hlth Res Ctr, Dept Anat, Dunedin, New Zealand 6.Univ South Dakota, Ctr Brain & Behav Res, Vermillion, SD USA 7.Univ Wisconsin, Dept Psychol, Ctr Hlth Minds, 1202 W Johnson St, Madison, WI 53706 USA 8.UCL, Ctr Med Image Comp Comp Sci, London, England 9.Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia 10.US Fed Aviat Adm, Civil Aerosp Med Inst, Oklahoma City, OK USA 11.Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA 12.Columbia Univ, Med Ctr, Manhattan, KS USA 13.UCL, Inst Neurol, Dementia Res Ctr, London, England 14.Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium 15.Univ Western Ontario, Dept Med Biophys, London, ON, Canada 16.Western Univ, Dept Neurosci, London, ON, Canada 17.Univ Deusto, Dept Personal Psychol Assessment & Treatment, Bilbao, Spain 18.Ohio State Univ, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA 19.Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI USA 20.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA 21.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA USA 22.Vanderbilt Univ Sch Med, Dept Psychiat & Behav Sci, Nashville, TN USA 23.Univ Amsterdam, Dept Psychiat, Amsterdam Univ Med Ctr Locat, Acad Med Ctr,Amsterdam Neurosci, Amsterdam, Netherlands 24.Vrije Univ Amsterdam, VU Univ Med Ctr, Amsterdam Univ Med Ctr Locat, Dept Psychiat, Amsterdam, Netherlands 25.Vrije Univ Amsterdam Med Ctr, GGZ Geest Amsterdam Neurosci, Amsterdam Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands 26.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA 27.Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA 28.VA Boston Healthcare Syst, Dept Psychiat, Brockton, MA USA 29.Western Univ, Dept Psychiat, London, ON, Canada 30.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA 31.Univ British Columbia, Dept Psychol, Okanagan, BC, Canada 32.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 33.Univ South Dakota, Dept Psychol, Vermillion, SD USA 34.Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA 35.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychosomat Med & Psychotherapy, Mannheim, Germany 36.Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN USA 37.Harvard Med Sch, Dept Radiol, Boston, MA 02115 USA 38.Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA 39.Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA 40.Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA 41.Univ South Dakota, Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD USA 42.McLean Hosp, Div Depress & Anxiety Disorders, 115 Mill St, Belmont, MA 02178 USA 43.McLean Hosp, Div Womens Mental Hlth, 115 Mill St, Belmont, MA 02178 USA 44.Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands 45.Harvard Med Sch, Boston, MA 02115 USA 46.Lawson Hlth Res Inst, Imaging Div, London, ON, Canada 47.Harvard Univ, McLean Hosp, Inst Technol Psychiat, Belmont, MA 02178 USA 48.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany 49.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Lab Traumat Stress Studies, Beijing, Peoples R China 50.Marquette Univ, Milwaukee, WI 53233 USA 51.McLean Hosp, 115 Mill St, Belmont, MA 02178 USA 52.Med Coll Wisconsin, Milwaukee, WI 53226 USA 53.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 54.New York State Psychiat Inst & Hosp, New York, NY 10032 USA 55.Orygen, Parkville, Vic, Australia 56.Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA 57.Sioux Falls VA Hlth Care Syst, Sioux Falls, SD USA 58.Univ Calif San Diego, Dept Family Med & Publ Hlth, San Deigo, CA USA 59.Univ Calif San Diego, Dept Psychiat, San Deigo, CA USA 60.Univ Med Ctr Charite, Berlin, Germany 61.Univ Groningen, Groningen, Netherlands 62.Univ Wisconsin, Milwaukee, WI 53201 USA 63.VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Deigo, CA USA 64.Stanford Univ, Wu Tsai Neurosci Inst, Stanford, CA 94305 USA 65.Western Univ, Dept Psychol, London, ON, Canada 66.Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA 67.Michael E DeBakey VA Med Ctr, Houston, TX USA 68.Baylor Coll Med, Menninger Dept Psychiat, Houston, TX 77030 USA |
推荐引用方式 GB/T 7714 | Clausen, Ashley N.,Fercho, Kelene A.,Monsour, Molly,et al. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups[J]. BRAIN AND BEHAVIOR,2021:14. |
APA | Clausen, Ashley N..,Fercho, Kelene A..,Monsour, Molly.,Disner, Seth.,Salminen, Lauren.,...&Morey, Rajendra A..(2021).Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.BRAIN AND BEHAVIOR,14. |
MLA | Clausen, Ashley N.,et al."Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups".BRAIN AND BEHAVIOR (2021):14. |
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