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Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder
Mu, Li1,2; Yu, Feng3; Xia, Jiejing3; Lang, XiaoE4; Haque, Anam5; Wu, Hanjing Emily5; Zhang, Xiang Yang6
第一作者Li Mu
通讯作者邮箱zhangxy@psych.ac.cn (x.y. zhang)
心理所单位排序6
摘要

Background: Bipolar disorder (BD) has been associated with an increased prevalence of weight gain and abnormally elevated plasma homocysteine (Hcy) levels. However, the relationship between BMI and Hcy in BD patients has not been investigated. This study aimed to explore this relationship in Chinese patients with BD. Methods: Plasma Hcy levels, socio-demographic parameters, clinical and anthropometric data were collected from 195 BD inpatients and 84 healthy controls. The level of plasma Hcy was determined by high-performance liquid chromatography. Body mass index (BMI) was calculated by body weight divided by the square of the height. The participants were divided into a high BMI group and a low BMI group using 24 kg/m(2) as a threshold. Results: The prevalence of high BMI was slightly elevated in BD patients in comparison to healthy controls. Patients with elevated BMI had significantly higher Hcy levels than patients with low BMI. Hcy level was an independent contributor of the occurrence of high BMI in BD patients. The level of Hcy was positively correlated with BMI in BD patients. In addition, depressive episodes of BD were positively correlated with the prevalence of high BMI and married BD patients were more likely to have high BMI levels. Conclusions: There is a close relationship between BMI and plasma Hcy levels in patients with BD, suggesting that Hcy may be an important indicator for BD-induced weight gain. This finding provides a new avenue for weight management of BD patients and to help avoid the potential risk of cardiovascular diseases.

关键词Bipolar disorder Body mass index Homocysteine Depressive episodes
2021-12-01
语种英语
DOI10.1016/j.jad.2021.08.032
发表期刊JOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
卷号295页码:284-290
期刊论文类型实证研究
收录类别SCI
资助项目CAS Pioneer Hundred Talents Program
出版者ELSEVIER
WOS关键词BODY-MASS INDEX ; MAJOR DEPRESSIVE DISORDER ; METABOLIC SYNDROME ; PHYSICAL-EXERCISE ; OBESITY ; RISK ; PREVALENCE ; OVERWEIGHT ; SCHIZOPHRENIA ; ADOLESCENTS
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Psychiatry
WOS记录号WOS:000741334700037
WOS分区Q1
资助机构CAS Pioneer Hundred Talents Program
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/41807
专题中国科学院心理健康重点实验室
通讯作者Zhang, Xiang Yang
作者单位1.Liaoning Normal Univ, Res Ctr Brain & Cognit Neurosci, Dalian, Peoples R China
2.Key Lab Brain & Cognit Neurosci, Dalian, Liaoning, Peoples R China
3.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China
4.Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Mu, Li,Yu, Feng,Xia, Jiejing,et al. Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,295:284-290.
APA Mu, Li.,Yu, Feng.,Xia, Jiejing.,Lang, XiaoE.,Haque, Anam.,...&Zhang, Xiang Yang.(2021).Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder.JOURNAL OF AFFECTIVE DISORDERS,295,284-290.
MLA Mu, Li,et al."Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder".JOURNAL OF AFFECTIVE DISORDERS 295(2021):284-290.
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