Institutional Repository of Key Laboratory of Mental Health, CAS
Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder | |
Li, Xiao-Yan1; Tabarak, Serik2,3,4; Su, Xiu-Ru1; Qin, Zengchang6; Chai, Yuan6; Zhang, Shunyu6; Wang, Ke-Qiang1; Guan, Heng-Yong1; Lu, Shu-Lan1; Chen, Ying-Nan1; Chen, Hong-Mei1; Zhao, Long1; Lu, Yan-Xin1; Li, Su-Xia4,5; Zhang, Xiang-Yang7,8 | |
第一作者 | Xiao-Yan Li |
通讯作者邮箱 | li313@bjmu.edu.cn (s.-x. li) ; zhangxy@psych.ac.cn (x.-y. zhang) |
心理所单位排序 | 7 |
摘要 | Background: Major depressive disorder (MDD) is the most common mental disorder associated with suicide attempts. When a patient first visits the clinic, clinicians are often expected to make concrete diagnose about acute suicidal risk. However, the timeliness of suicide attempts correlates with patients with MDD has not been tested. Methods: We divided 1718 first-episode and untreated MDD outpatients into those who did not have suicide attempts (non-attempts), recent suicide attempters (<= 14 days before assessment) and long - dated suicide attempters (> 30 days before assessment). Positive Symptom Scale of Positive and Negative Syndrome Scale (PANSS), the 17-item Hamilton Depression Scale, 14 - item Hamilton Anxiety Scale, and clinical global impression of severity scale (CGI-S) was assessed. Body mass index, some glycolipid metabolism and thyroid hormone parameters were measured. A gradient-boosted decision trees statistical model was used to generate equally weighted classification for distinguishing recent and long - dated suicide attempters from non-attempts. Results: The classifier identified higher excitement, hostility, anxiety, depression symptoms and higher free thyroxine (FT4) as risk factors for recent suicide attempters with an estimated accuracy of 87% (sensitivity, 59.1%; specificity, 61.2 %). For long - dated suicide attempters' risk factors, single status, higher anxiety and hostility symptoms, higher LDLC and lower BMI, the estimated accuracy was 88% (sensitivity, 52.8%; specificity, 49.6%). Conclusions: Risk factors for suicide attempt among patients with MDD can be identified by integrating demographic, clinical, and biological variables as early as possible during the first time see a doctor. |
关键词 | Major depressive disorder Suicide attempt Risk factor Machine learning XG-boost |
2021-12-01 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2021.08.028 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 295页码:264-270 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Natural Science Foundation of China[81871071] ; Natural Science Foundation of China[81171251] ; Natural Science Foundation of Beijing[7162101] |
出版者 | ELSEVIER |
WOS关键词 | TOWER-OF-BABEL ; 1ST-EPISODE PSYCHOSIS ; MENTAL-DISORDERS ; FOLLOW-UP ; BEHAVIOR ; NOMENCLATURE ; PREDICTORS ; MODEL ; OPUS |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000741334700035 |
WOS分区 | Q1 |
资助机构 | Natural Science Foundation of China ; Natural Science Foundation of Beijing |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/41813 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Li, Su-Xia; Zhang, Xiang-Yang |
作者单位 | 1.Rong Jun Hosp, Baoding 071000, Hebei, Peoples R China 2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China 3.Peking Univ, McGovern Inst Brain Res, PKU IDG, Beijing, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing Key Lab Drug Dependence, Beijing, Peoples R China 5.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Beijing, Peoples R China 6.Beihang Univ, Sch Automat Sci & Elect Engn, Intelligent Comp & Machine Learning Lab, Beijing 100191, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Li, Xiao-Yan,Tabarak, Serik,Su, Xiu-Ru,et al. Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,295:264-270. |
APA | Li, Xiao-Yan.,Tabarak, Serik.,Su, Xiu-Ru.,Qin, Zengchang.,Chai, Yuan.,...&Zhang, Xiang-Yang.(2021).Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,295,264-270. |
MLA | Li, Xiao-Yan,et al."Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 295(2021):264-270. |
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