Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium

doi:10.1017/S0033291722000320

PSYCH OpenIR

	Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium
通讯作者	Qiu, Jiang(qiuj318@swu.edu.cn) ; Zhu, XingXing(x.zhu.4@research.gla.ac.uk)
摘要	Background Neuroimaging studies on major depressive disorder (MDD) have identified an extensive range of brain structural abnormalities, but the exact neural mechanisms associated with MDD remain elusive. Most previous studies were performed with voxel- or surface-based morphometry which were univariate methods without considering spatial information across voxels/vertices. Methods Brain morphology was investigated using voxel-based morphometry (VBM) and source-based morphometry (SBM) in 1082 MDD patients and 990 healthy controls (HCs) from the REST-meta-MDD Consortium. We first examined group differences in regional grey matter (GM) volumes and structural covariance networks between patients and HCs. We then compared first-episode, drug-naive (FEDN) patients, and recurrent patients. Additionally, we assessed the effects of symptom severity and illness duration on brain alterations. Results VBM showed decreased GM volume in various regions in MDD patients including the superior temporal cortex, anterior and middle cingulate cortex, inferior frontal cortex, and precuneus. SBM returned differences only in the prefrontal network. Comparisons between FEDN and recurrent MDD patients showed no significant differences by VBM, but SBM showed greater decreases in prefrontal, basal ganglia, visual, and cerebellar networks in the recurrent group. Moreover, depression severity was associated with volumes in the inferior frontal gyrus and precuneus, as well as the prefrontal network. Conclusions Simultaneous application of VBM and SBM methods revealed brain alterations in MDD patients and specified differences between recurrent and FEDN patients, which tentatively provide an effective multivariate method to identify potential neurobiological markers for depression.
关键词	Brain structure major depressive disorder source-based morphometry structural covariance network voxel-based morphometry
	2022-02-15
语种	英语
DOI	10.1017/S0033291722000320
发表期刊	PSYCHOLOGICAL MEDICINE
ISSN	0033-2917
页码	11
收录类别	SCI
资助项目	National Natural Science Foundation of China[32000760] ; China Postdoctoral Science Foundation[2019M662433] ; Postdoctoral Innovation Project in Shandong Province[239735] ; National Social Science Foundation of China[21AYY014] ; Fundamental Research Funds for the Provincial Universities of Zhejiang ; China Scholarship Council
出版者	CAMBRIDGE UNIV PRESS
WOS关键词	GRAY-MATTER ; ORBITOFRONTAL CORTEX ; PREFRONTAL CORTEX ; BASAL GANGLIA ; NETWORK ; COVARIANCE ; INFORMATION ; CEREBELLUM ; RECURRENCE ; MECHANISMS
WOS研究方向	Psychology ; Psychiatry
WOS类目	Psychology, Clinical ; Psychiatry ; Psychology
WOS记录号	WOS:000755383600001
资助机构	National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Postdoctoral Innovation Project in Shandong Province ; National Social Science Foundation of China ; Fundamental Research Funds for the Provincial Universities of Zhejiang ; China Scholarship Council
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/41943
推荐引用方式 GB/T 7714	. Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium[J]. PSYCHOLOGICAL MEDICINE,2022:11.
APA	(2022).Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium.PSYCHOLOGICAL MEDICINE,11.
MLA	"Brain structural abnormalities in adult major depressive disorder revealed by voxel- and source-based morphometry: evidence from the REST-meta-MDD Consortium".PSYCHOLOGICAL MEDICINE (2022):11.