Impaired social decision making in patients with major depressive disorder

doi:10.1186/1471-244X-14-18

PSYCH OpenIR

	Impaired social decision making in patients with major depressive disorder
	Wang,Yun 1,2; Zhou,Yuan 1; Li,Shu 1; Wang,Peng 3; Wu,Guo-Wei 3; Liu,Zhe-Ning 3
通讯作者	Zhou,Yuan(zhouyuan@psych.ac.cn)
摘要	AbstractBackgroundAbnormal decision-making processes have been observed in patients with major depressive disorder (MDD). However, it is unresolved whether MDD patients show abnormalities in decision making in a social interaction context, in which decisions have actual influences on both the self-interests of the decision makers per se and those of their partners.MethodsUsing a well-studied ultimatum game (UG), which is frequently used to investigate social interaction behavior, we examined whether MDD can be associated with abnormalities in social decision-making behavior by comparing the acceptance rates of MDD patients (N?=?14) with those of normal controls (N?=?19).ResultsThe acceptance rates of the patients were lower than those of the normal controls. Additionally, unfair proposals were accepted at similar rates from computer partners and human partners in the MDD patients, unlike the acceptance rates in the normal controls, who were able to discriminatively treat unfair proposals from computer partners and human partners.ConclusionsDepressed patients show abnormal decision-making behavior in a social interaction context. Several possible explanations, such as increased sensitivity to fairness, negative emotional state and disturbed affective cognition, have been proposed to account for the abnormal social decision-making behavior in patients with MDD. This aberrant social decision-making behavior may provide a new perspective in the search to find biomarkers for the diagnosis and prognosis of MDD.
关键词	Ultimatum game Major depressive disorder Decision making Fairness
	2014-01-23
语种	英语
DOI	10.1186/1471-244X-14-18
发表期刊	BMC Psychiatry
ISSN	1471-244X
卷号	14 期号:1
出版者	BioMed Central
WOS记录号	BMC:10.1186/1471-244X-14-18
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/41984
通讯作者	Zhou,Yuan
作者单位	1.Chinese Academy of Sciences; Key Laboratory of Behavioral Science, Institute of Psychology 2.University of Chinese Academy of Sciences 3.Second Xiangya Hospital of Central South University; Institute of Mental Health
推荐引用方式 GB/T 7714	Wang,Yun,Zhou,Yuan,Li,Shu,et al. Impaired social decision making in patients with major depressive disorder[J]. BMC Psychiatry,2014,14(1).
APA	Wang,Yun,Zhou,Yuan,Li,Shu,Wang,Peng,Wu,Guo-Wei,&Liu,Zhe-Ning.(2014).Impaired social decision making in patients with major depressive disorder.BMC Psychiatry,14(1).
MLA	Wang,Yun,et al."Impaired social decision making in patients with major depressive disorder".BMC Psychiatry 14.1(2014).