Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors

doi:10.3390/ijerph19042387

PSYCH OpenIR

	Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors
	Wang, Xiaqing 1,2; Bao, Chongyu 1,2; Li, Zhenjiang 1,2; Yue, Lupeng 1,2; Hu, Li 1,2
通讯作者	Yue, Lupeng(huli@psych.ac.cn) ; Hu, Li(huli@psych.ac.cn)
摘要	Humans have used opioids to suppress moderate to severe pain for thousands of years. However, the long-term use of opioids has several adverse effects, such as opioid tolerance, opioid-induced hyperalgesia, and addiction. In addition, the low efficiency of opioids in controlling neuropathic pain limits their clinical applications. Combining nonopioid analgesics with opioids to target multiple sites along the nociceptive pathway may alleviate the side effects of opioids. This study reviews the feasibility of reducing opioid side effects by regulating the transient receptor potential vanilloid 1 (TRPV1) receptors and summarizes the possible underlying mechanisms. Blocking and activating TRPV1 receptors can improve the therapeutic profile of opioids in different manners. TRPV1 and mu-opioid receptors are bidirectionally regulated by beta-arrestin2. Thus, drug combinations or developing dual-acting drugs simultaneously targeting mu-opioid and TRPV1 receptors may mitigate opioid tolerance and opioid-induced hyperalgesia. In addition, TRPV1 receptors, especially expressed in the dorsal striatum and nucleus accumbens, participate in mediating opioid reward, and its regulation can reduce the risk of opioid-induced addiction. Finally, co-administration of TRPV1 antagonists and opioids in the primary action sites of the periphery can significantly relieve neuropathic pain. In general, the regulation of TRPV1 may potentially ameliorate the side effects of opioids and enhance their analgesic efficacy in neuropathic pain.
关键词	TRPV1 mu-opioid opioid side effects neuropathic pain beta-arrestin2
	2022-02-01
语种	英语
DOI	10.3390/ijerph19042387
发表期刊	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷号	19 期号:4 页码:11
收录类别	SCI
资助项目	National Natural Science Foundation of China[32071061] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[32000749] ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Science[2020000197]
出版者	MDPI
WOS关键词	POSTOPERATIVE PAIN MANAGEMENT ; NEUROPATHIC PAIN ; SYSTEMIC MORPHINE ; SENSORY NEURONS ; INDUCED TOLERANCE ; PLACE PREFERENCE ; ANTAGONIST ; EXPRESSION ; MODEL ; ACTIVATION
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health
WOS记录号	WOS:000773060000001
资助机构	National Natural Science Foundation of China ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Science
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/42300
通讯作者	Yue, Lupeng; Hu, Li
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiaqing,Bao, Chongyu,Li, Zhenjiang,et al. Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,2022,19(4):11.
APA	Wang, Xiaqing,Bao, Chongyu,Li, Zhenjiang,Yue, Lupeng,&Hu, Li.(2022).Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,19(4),11.
MLA	Wang, Xiaqing,et al."Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors".INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 19.4(2022):11.