Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China

doi:10.1111/bdi.13139

PSYCH OpenIR

	Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China
	Deng, Ke 1,2,3; Yue, Ji-Hui 4,5; Xu, Jian 6; Ma, Ping-Ping 1,7; Chen, Xiao 8,9; Li, Le 8,9; Bai, Tong-Jian 10; Bo, Qi-Jing 11; Cao, Jun 12; Chen, Guan-Mao 13; Chen, Ning-Xuan 8,9; Chen, Wei 14; Cheng, Chang 15; Cui, Xi-Long 16; Duan, Jia 16; Fang, Yi-Ru 17; Gong, Qi-Yong 18,19; Guo, Wen-Bin 15; Hou, Zheng-Hua 20; Hu, Lan 12; Kuang, Li 12; Li, Feng 11; Li, Tao 21; Liu, Yan-Song 22; Liu, Zhe-Ning 15; Long, Yi-Cheng 15; Luo, Qing-Hua 12; Meng, Hua-Qing 12; Peng, Dai-Hui 17; Qiu, Hai-Tang 12; Qiu, Jiang 23; Shi, Yu-Shu 24; Si, Tian-Mei 25,26; Tang, Yan-Qin 16; Wang, Fei 16; Wang, Kai 10; Wang, Li 25,26; Wang, Xiang 15; Wang, Ying 13; Wu, Xiao-Ping 27; Wu, Xin-Ran 23; Xie, Chun-Ming 28; Xie, Guang-Rong 15; Xie, Hai-Yan 29; Xie, Peng 30,31,32; Yang, Hong 24; Yang, Jian 33; Yao, Jia-Shu 14; Yao, Shu-Qiao 15; Yin, Ying-Ying 20; Yuan, Yong-Gui 20; Zhang, Ai-Xia 33; Zhang, Hong 27; Zhang, Ke-Rang 34; Zhang, Lei 8,9; Zhang, Zhi-Jun 28; Zhou, Ru-Bai 17; Zhou, Yi-Ting 21; Zhu, Jun-Juan 17; Zou, Chao-Jie 1; Zhou, Cong 1; Zuo, Xi-Nian 8,9; Yan, Chao-Gan 8,9; Xu, Xiu-Feng 1; Cheng, Yu-Qi 1
通讯作者	Cheng, Yu-Qi(yuqicheng@126.com)
摘要	Background Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < 0.002, z = -7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction in MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
关键词	functional connectivity (FC) functional homotopy (FH) interhemispheric function integration major depressive disorder (MDD) resting-state functional magnetic resonance imaging (R-fMRI) voxel-mirrored homotopic connectivity (VMHC)
	2022-03-20
语种	英语
DOI	10.1111/bdi.13139
发表期刊	BIPOLAR DISORDERS
ISSN	1398-5647
页码	12
收录类别	SCI
资助项目	National Natural Science Foundation of China[82060259] ; National Natural Science Foundation of China[81760296] ; National Natural Science Foundation of China[81660237] ; Medical Leader Foundation of Yunnan Province[L2019011] ; Medical Leader Foundation of Yunnan Province[L2019004] ; Famous Doctors Project of Yunnan Province Plan[YNWR-MY-2018-040] ; Famous Doctors Project of Yunnan Province Plan[YNWR-MY-2018-041] ; Applied Basic Key Project of Yunnan Provincial Department of Science and Technology--Kunming Medical University Joint Foundation[2017FE468(-176)]
出版者	WILEY
WOS关键词	SEX-DIFFERENCES ; HOMOTOPIC CONNECTIVITY ; DRUG-NAIVE ; DISORDER ; 1ST-EPISODE ; FLUCTUATIONS ; COORDINATION ; PRECUNEUS
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Neurosciences ; Psychiatry
WOS记录号	WOS:000770833000001
资助机构	National Natural Science Foundation of China ; Medical Leader Foundation of Yunnan Province ; Famous Doctors Project of Yunnan Province Plan ; Applied Basic Key Project of Yunnan Provincial Department of Science and Technology--Kunming Medical University Joint Foundation
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/42316
通讯作者	Cheng, Yu-Qi
作者单位	1.Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China 2.Jiaxing Univ, Dept Psychiat, Hosp Jiaxing 1, Jiaxing, Zhejiang, Peoples R China 3.Jiaxing Univ, Affiliated Hosp 1, Jiaxing, Zhejiang, Peoples R China 4.Sun Yat Sen Univ, Affiliated Hosp 5, Dept Psychiat, Zhuhai, Guangdong, Peoples R China 5.Sun Yat Sen Univ, Affiliated Hosp 5, Res Ctr Mol Imaging, Zhuhai, Guangdong, Peoples R China 6.Kunming Med Univ, Affiliated Hosp 1, Dept Rheumatol, Kunming, Yunnan, Peoples R China 7.Fifth Peoples Hosp Zigong City, Zigong, Sichuan, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 9.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 10.Anhui Med Univ, Hefei, Anhui, Peoples R China 11.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 12.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China 13.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 14.Zhejiang Univ, Sir Run Shaw Hosp, Dept Psychiat, Sch Med, Hangzhou, Zhejiang, Peoples R China 15.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China 16.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China 17.Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai, Peoples R China 18.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, West China Hosp, Chengdu, Sichuan, Peoples R China 19.Sichuan Univ, Psychoradiol Res Unit, Chinese Acad Med Sci, West China Hosp, Chengdu, Sichuan, Peoples R China 20.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing, Jiangsu, Peoples R China 21.Sichuan Univ Chengdu, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China 22.Soochow Univ, Dept Clin Psychol, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China 23.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 24.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou, Zhejiang, Peoples R China 25.Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 26.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China 27.Xian Cent Hosp, Xian, Shaanxi, Peoples R China 28.Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China 29.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China 30.Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China 31.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China 32.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China 33.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China 34.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China
推荐引用方式 GB/T 7714	Deng, Ke,Yue, Ji-Hui,Xu, Jian,et al. Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China[J]. BIPOLAR DISORDERS,2022:12.
APA	Deng, Ke.,Yue, Ji-Hui.,Xu, Jian.,Ma, Ping-Ping.,Chen, Xiao.,...&Cheng, Yu-Qi.(2022).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.BIPOLAR DISORDERS,12.
MLA	Deng, Ke,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China".BIPOLAR DISORDERS (2022):12.