Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network

doi:10.1016/j.neuroscience.2022.04.002

PSYCH OpenIR

	Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network
	Zhao, Lei 1,2,3,4; Bo, Qijing 1,2,3,4; Zhang, Zhifang 1,2,3,4; Chen, Zhenzhu 1,2,3,4; Wang, Yimeng 1,2,3,4; Zhang, Douyu 1,2,3,4; Li, Tian 1,2,3,4; Yang, Ningbo 7; Zhou, Yuan 1,2,3,5,6; Wang, Chuanyue 1,2,3,4
通讯作者	Zhou, Yuan(zhouyuan@psych.ac.cn) ; Wang, Chuanyue(wcyadyy@163.com)
摘要	early psychosis there are alterations in the static functional interaction between the salience network (SN) and higher-order cognitive networks. It is unclear whether these changes extend to the dynamic functional connectivity (dFC) of the SN, and whether the dFC between the SN and low-order networks (e.g., sensory networks) is affected. This study examined the temporal properties of the functional connectivity of the SN in individuals with early psychosis. In this study, selected core regions of the SN included the left and right anterior insula (AIs) and anterior cingulate cortex (ACC), based on independent component analysis of 26 and 20 subjects with first-episode schizophrenia (FES) or at clinical high risk for psychosis (CHR), and 37 healthy controls (HC). The dFC of each region was investigated via sliding window-based analyses with whole brain voxels. We found compared with the HC, in the FES and CHR groups the bilateral AI and ACC showed less variability in dFC with regions in the visual network; the variability between the ACC and visual regions in the FES group was less than that of the CHR; and in the FES and CHR groups the variability in dFC was higher between the right AI and the left precuneus (a core region of the default mode network). This study confirmed abnormality of dynamic functional interaction between the SN and the DMN in psychosis. More importantly, the disruption of communication between the SN and the lower-order brain network is another important aspect of the neural basis of psychosis. (c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词	first-episode schizophrenia clinical high risk for psychosis salience network visual network default mode network dynamic functional connectivity
	2022-05-21
语种	英语
DOI	10.1016/j.neuroscience.2022.04.002
发表期刊	NEUROSCIENCE
ISSN	0306-4522
卷号	491 页码:166-175
收录类别	SCI
资助项目	National Science and Technology Major Project for IND (investigational new drug)[2018ZX09201-014] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201807] ; Beijing Municipal Natural Science Foundation[7192081] ; National Natural Science Foundation of China[81901355]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	AUDITORY VERBAL HALLUCINATIONS ; RESTING-STATE CONNECTIVITY ; 1ST EPISODE PSYCHOSIS ; BRAIN NETWORKS ; SCHIZOPHRENIA ; PRECUNEUS ; CORTEX ; INDIVIDUALS ; MODULATION ; RESPONSES
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000793823600002
资助机构	National Science and Technology Major Project for IND (investigational new drug) ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/42676
通讯作者	Zhou, Yuan; Wang, Chuanyue
作者单位	1.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 3.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders Ctr Schizophrenia, Beijing 100088, Peoples R China 4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China 5.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 7.Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Psychiat, Luoyang 471003, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Lei,Bo, Qijing,Zhang, Zhifang,et al. Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network[J]. NEUROSCIENCE,2022,491:166-175.
APA	Zhao, Lei.,Bo, Qijing.,Zhang, Zhifang.,Chen, Zhenzhu.,Wang, Yimeng.,...&Wang, Chuanyue.(2022).Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network.NEUROSCIENCE,491,166-175.
MLA	Zhao, Lei,et al."Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network".NEUROSCIENCE 491(2022):166-175.