Institutional Repository of Key Laboratory of Mental Health, CAS
Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis | |
Zhao, Chengbowen1,2; Wei, Xiaojia1; Guo, Jianyou3; Ding, Yongsheng1; Luo, Jing1; Yang, Xue1; Li, Jiayuan1; Wan, Guohui1; Yu, Jiahe1; Shi, Jinli1 | |
第一作者 | Chengbowen Zhao |
通讯作者邮箱 | shijl@bucm.edu.com |
心理所单位排序 | 3 |
摘要 | Anxiety disorder impacts the quality of life of the patients. The 95% ethanol extract of rhizomes and roots of Valeriana jatamansi Jones (Zhi zhu xiang, ZZX) has previously been shown to be effective for the treatment of anxiety disorder. In this study, the dose ratio of each component of the anxiolytic compounds group (ACG) in a 95% ethanol extract of ZZX was optimized by a uniform design experiment and mathematical modeling. The anxiolytic effect of ACG was verified by behavioral experiments and biochemical index measurement. Network pharmacology was used to determine potential action targets, as well as predict biological processes and signaling pathways, which were then verified by molecular docking analysis. Metabolomics was then used to screen and analyze metabolites in the rat hippocampus before and after the administration of ZZX-ACG. Finally, the results of metabolomics and network pharmacology were integrated to clarify the anti-anxiety mechanism of the ACG. The optimal dose ratio of ACG in 95% ethanol extract of ZZX was obtained, and our results suggest that ACG may regulate ALB, AKT1, PTGS2, CYP3A4, ESR1, CASP3, CYP2B6, EGFR, SRC, MMP9, IGF1, and MAPK8, as well as the prolactin signaling pathway, estrogen signaling pathway, and arachidonic acid metabolism pathway, thus affecting the brain neurotransmitters and HPA axis hormone levels to play an anxiolytic role, directly or indirectly. |
关键词 | Valeriana jatamansi Jones anxiety disorder network pharmacology metabolomics arachidonic acid metabolism |
2022-05-01 | |
语种 | 英语 |
DOI | 10.3390/brainsci12050589 |
发表期刊 | BRAIN SCIENCES |
卷号 | 12期号:5页码:21 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81673560] ; National Natural Science Foundation of China[82073971] |
出版者 | MDPI |
WOS关键词 | ANXIETY ; ESTROGEN ; RECEPTOR ; STRESS ; EXPRESSION ; PROLACTIN ; APOPTOSIS ; AMYGDALA ; EXTRACT ; GPR30 |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000803450600001 |
WOS分区 | Q3 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/42749 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Shi, Jinli |
作者单位 | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China 2.Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100007, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100083, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Chengbowen,Wei, Xiaojia,Guo, Jianyou,et al. Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis[J]. BRAIN SCIENCES,2022,12(5):21. |
APA | Zhao, Chengbowen.,Wei, Xiaojia.,Guo, Jianyou.,Ding, Yongsheng.,Luo, Jing.,...&Shi, Jinli.(2022).Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis.BRAIN SCIENCES,12(5),21. |
MLA | Zhao, Chengbowen,et al."Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis".BRAIN SCIENCES 12.5(2022):21. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Dose Optimization of(8347KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论