Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment

doi:10.1016/j.jpsychires.2022.04.029

PSYCH OpenIR

	Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment
	Liang, Qilin 1,2; Wang, Dongmei 3,4; Zhou, Huixia 3,4; Chen, Dachun 5; Xiu, Meihong 5; Cui, Lixia 1,2; Zhang, Xiangyang 3,4
通讯作者	Cui, Lixia(clx668@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Objective: Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia. Methods: We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition. Results: The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (chi 2 = 6.1 df = 1, p < 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p < 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p < 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore. Conclusion: Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.
关键词	Schizophrenia Tardive dyskinesia Clinical symptom Cognition
	2022-07-01
语种	英语
DOI	10.1016/j.jpsychires.2022.04.029
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH
ISSN	0022-3956
卷号	151 页码:181-187
收录类别	SCI
资助项目	Beijing Philosophy and Social Science Planning Program and Social Science Research Key Program of Beijing Municipal Commission of Education[SZ202210028012] ; CAS International Cooperation Research Program[153111KYSB20190004]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	PSYCHIATRIC-PATIENTS ; GENDER-DIFFERENCES ; NEGATIVE SYMPTOMS ; ANTIPSYCHOTICS ; ASSOCIATION ; RISK ; CLOZAPINE ; DYSFUNCTION ; CYP2D6 ; POLYMORPHISMS
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000797532400025
资助机构	Beijing Philosophy and Social Science Planning Program and Social Science Research Key Program of Beijing Municipal Commission of Education ; CAS International Cooperation Research Program
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/42750
通讯作者	Cui, Lixia; Zhang, Xiangyang
作者单位	1.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning, Beijing 100037, Peoples R China 2.Capital Normal Univ, Sch Psychol, Beijing 100037, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
推荐引用方式 GB/T 7714	Liang, Qilin,Wang, Dongmei,Zhou, Huixia,et al. Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2022,151:181-187.
APA	Liang, Qilin.,Wang, Dongmei.,Zhou, Huixia.,Chen, Dachun.,Xiu, Meihong.,...&Zhang, Xiangyang.(2022).Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment.JOURNAL OF PSYCHIATRIC RESEARCH,151,181-187.
MLA	Liang, Qilin,et al."Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment".JOURNAL OF PSYCHIATRIC RESEARCH 151(2022):181-187.