Institutional Repository of Key Laboratory of Mental Health, CAS
Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress | |
Li, Yuling1,2; Wang, Yuan3; Guan, Xin3; Yue, Jingyan4; Wu, Hanjing Emily4; Zhen, Shiqian5; He, Shu-Chang1,2; Zhang, Xiang-Yang6 | |
第一作者 | Yuling Li |
通讯作者邮箱 | zhenshiqian@caitec.org.cn (shiqian zhen) ; shuchangh@pku.edu.cn (shu-chang he,) ; zhangxy@psych.ac.cn (zhangxy@psych.ac.cn) |
心理所单位排序 | 6 |
摘要 | The oxytocin receptors located in the corticotropin-releasing factor neurons of the paraventricular nucleus are stimulated by oxytocin. Oxytocin functions as the regulator of the corticotropin-releasing factor system and in turn promotes sleep quality. The objective of this study was to examine the main and genotype-genotype interactive effects of the oxytocin receptor gene (OXTR) polymorphisms on sleep quality. A total of 324 participants were randomly recruited from a university in Beijing, China. Sleep quality was measured with the Pittsburgh Sleep Quality Index. The OXTR single-nucleotide polymorphisms (rs2254298, rs2268498, rs13316193, rs2268490 and rs2268491) were genotyped. The results showed that gender and age were associated with various empathy traits (all p < 0.001). The Pittsburgh Sleep Quality Index was positively correlated with the Personal Distress subscale of empathy (p < 0.001). Both rs2254298 and rs2268491 interacted with rs13316193 to influence daytime dysfunction and Personal Distress (all p < 0.05), indicating that in individuals with rs13316193 CC/CT genotype, those with rs2254298 AA/AG or rs2268491 TT/TC genotypes displayed higher daytime dysfunction and Personal Distress scores than those with rs2254298 GG or rs2268491 CC genotypes. Conversely, among the individuals with rs2254298 GG or rs2268491 CC genotypes, the rs13316193 C allele carriers had lower daytime dysfunction and Personal Distress scores than rs13316193 TT homozygotes. There was also a significant interaction between rs2268490 and rs2268498 on the sleep latency dimension of the Pittsburgh Sleep Quality Index. Our findings reveal for the first time the genotype-genotype interactions of the OXTR gene on sleep quality, which may open new research avenues for studying psychopathology involving sleep problems. |
关键词 | daytime dysfunction emotional empathy genotype-genotype interaction oxytocin receptor gene (OXTR) personal distress sleep latency |
2022-06-15 | |
语种 | 英语 |
DOI | 10.1111/jsr.13668 |
发表期刊 | JOURNAL OF SLEEP RESEARCH |
ISSN | 0962-1105 |
页码 | 12 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81871060] |
出版者 | WILEY |
WOS关键词 | OXYTOCIN NEURONS ; WAKE BEHAVIOR ; RECEPTOR ; SYSTEM ; EMPATHY ; IMPACT ; DEPRIVATION ; WAKEFULNESS ; POPULATION ; QUALITY |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Clinical Neurology ; Neurosciences |
WOS记录号 | WOS:000811358100001 |
WOS分区 | Q2 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/42785 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhen, Shiqian; He, Shu-Chang; Zhang, Xiang-Yang |
作者单位 | 1.Peking Univ, Sch Psychol & Cognit Sci, Beijing, Peoples R China 2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China 3.PLA Strateg Support Force Med Ctr, Beijing, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Chinese Acad Int Trade & Econ Cooperat, Inst Circulat & Consumpt, 28 Donghou Lane, Beijing 100710, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Li, Yuling,Wang, Yuan,Guan, Xin,et al. Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress[J]. JOURNAL OF SLEEP RESEARCH,2022:12. |
APA | Li, Yuling.,Wang, Yuan.,Guan, Xin.,Yue, Jingyan.,Wu, Hanjing Emily.,...&Zhang, Xiang-Yang.(2022).Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress.JOURNAL OF SLEEP RESEARCH,12. |
MLA | Li, Yuling,et al."Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress".JOURNAL OF SLEEP RESEARCH (2022):12. |
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