Institutional Repository of Key Laboratory of Mental Health, CAS
Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia | |
Wu, Yuxuan1,2; Du, Xiangdong2; Yang, Ruchang1,2; Yue, Yan1,2; Peng, Ruijie1,2; Wu, Siqi3; Wang, Haitao3; Zhou, Yue2,4; Fang, Xiaojia2,4; Yuan, Nian2; Li, Ronghua2; Zhang, Jun2; Zou, Siyun2; Zhao, Xueli2; Lyu, Xiaoli2; Li, Zhe2; Zhang, Xiaobin2; Zhang, Xiangyang5 | |
第一作者 | Yuxuan Wu |
通讯作者邮箱 | xiangdong-du@163.com (xiangdong du ) ; zhangxy@psych.ac.cn (x. zhang)) |
心理所单位排序 | 5 |
摘要 | Previous studies have revealed that brain-derived neurotrophic factor (BDNF) levels are inversely associated with the severity of depressive symptoms. In addition, serum BDNF levels tend to increase with improvement in depressive symptoms. There is also evidence that BDNF has a possible role in the pathophysiology of schizophrenia. Therefore, the purpose of this study was to determine whether BDNF levels correlated with depressive symptoms in patients with first-episode and drug-naive (FEDN) schizophrenia. In this study, 90 patients with FEDN schizophrenia and 60 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the 17-item Hamilton Depression Scale (HAMD-17) were used to gage psychopathological and depressive symptoms, respectively. All participants had their BDNF levels measured using a sandwich enzyme-linked immunosorbent test. Serum BDNF levels were lower in patients with FEDN schizophrenia compared with healthy controls. Moreover, patients with depressive symptoms exhibited a higher PANSS total score and a higher general psychopathology score than those without depressive symptoms (p < 0.05). For patients with depressive symptoms, serum BDNF levels were higher than in those without depressive symptoms (p < 0.05). An association between BDNF levels and the positive subscore was also observed (p < 0.01). However, there was no significant association between BDNF levels and HAMD scores (p > 0.05). In conclusion, BDNF levels were shown to be higher in the serum of patients with FEDN schizophrenia with depressive symptoms than in those without. Additionally, low levels of serum BDNF may contribute to the positive symptoms of FEDN schizophrenia but not to depressive symptoms. |
关键词 | schizophrenia depressive symptoms brain-derived neurotrophic factor first episode psychosis serum |
2022-06-09 | |
语种 | 英语 |
DOI | 10.3389/fpsyt.2022.911384 |
发表期刊 | FRONTIERS IN PSYCHIATRY |
ISSN | 1664-0640 |
卷号 | 13页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | BDNF LEVELS ; NEGATIVE SYMPTOMS ; OXIDATIVE STRESS ; 1ST EPISODE ; MOOD DISORDERS ; DOPAMINE ; POLYMORPHISM ; PREVALENCE ; HYPOTHESIS ; BIOMARKERS |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000814881500001 |
WOS分区 | Q2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/42847 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
作者单位 | 1.Suzhou Med Coll Soochow Univ, Suzhou, Peoples R China 2.Affiliated Guangji Hosp Soochow Univ, Suzhou Guangji Hosp, Suzhou, Peoples R China 3.North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Tangshan, Peoples R China 4.Xuzhou Med Univ, Xuzhou, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wu, Yuxuan,Du, Xiangdong,Yang, Ruchang,et al. Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia[J]. FRONTIERS IN PSYCHIATRY,2022,13:8. |
APA | Wu, Yuxuan.,Du, Xiangdong.,Yang, Ruchang.,Yue, Yan.,Peng, Ruijie.,...&Zhang, Xiangyang.(2022).Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia.FRONTIERS IN PSYCHIATRY,13,8. |
MLA | Wu, Yuxuan,et al."Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia".FRONTIERS IN PSYCHIATRY 13(2022):8. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Association Between (495KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论