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Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia | |
Li, Hong1,2; Li, Xiaoyun2,3; Wang, Jiyuan1,2; Gao, Fei4; Wiech, Katja; Hu, Li2,3; Kong, Yazhuo1,2,5 | |
第一作者 | Hong Li |
通讯作者邮箱 | huli@psych.ac.cn (l. hu) ; kongyz@psych.ac.cn (yazhuo kong) |
心理所单位排序 | 1 |
摘要 | Studies on functional and structural changes in the primary somatosensory cortex (S1) have provided important insights into neural mechanisms underlying several chronic pain conditions. However, the role of S1 plasticity in postherpetic neuralgia (PHN) remains elusive. Combining psychophysics and magnetic resonance imaging (MRI), we investigated whether pain in PHN patients is linked to S1 reorganization as compared with healthy controls. Results from voxel-based morphometry showed no structural differences between groups. To characterize functional plasticity, we compared S1 responses to noxious laser stimuli of a fixed intensity between both groups and assessed the relationship between S1 activation and spontaneous pain in PHN patients. Although the intensity of evoked pain was comparable in both groups, PHN patients exhibited greater activation in S1 ipsilateral to the stimulated hand. Pain-related activity was identified in contralateral superior S1 (SS1) in controls as expected, but in bilateral inferior S1 (IS1) in PHN patients with no overlap between SS1 and IS1. Contralateral SS1 engaged during evoked pain in controls encoded spontaneous pain in patients, suggesting functional S1 reorganization in PHN. Resting-state fMRI data showed decreased functional connectivity between left and right SS1 in PHN patients, which scaled with the intensity of spontaneous pain. Finally, multivariate pattern analyses (MVPA) demonstrated that BOLD activity and resting-state functional connectivity of S1 predicted within-subject variations of evoked and spontaneous pain intensities across groups. In summary, functional reorganization in S1 might play a key role in chronic pain related to PHN and could be a potential treatment target in this patient group. |
关键词 | functional magnetic resonance imaging pain perception postherpetic neuralgia primary somatosensory cortex (S1) reorganization |
2022-06-25 | |
语种 | 英语 |
DOI | 10.1002/hbm.25992 |
发表期刊 | HUMAN BRAIN MAPPING |
ISSN | 1065-9471 |
页码 | 13 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81871436] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[82072010] ; National Natural Science Foundation of China[82101610] |
出版者 | WILEY |
WOS关键词 | CORTICAL REORGANIZATION ; NEUROPATHIC PAIN ; FUNCTIONAL MRI ; BRAIN ACTIVITY ; MEDIAN NERVE ; MECHANISMS ; PERCEPTION ; RESPONSES ; ACCURATE ; ATROPHY |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000815587600001 |
WOS分区 | Q1 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/42860 |
专题 | 中国科学院心理健康重点实验室 中国科学院行为科学重点实验室 |
通讯作者 | Hu, Li; Kong, Yazhuo |
作者单位 | 1.CAS Key Lab Behav Sci, Inst Psychol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 4.Peking Univ Peoples Hosp, Dept Pain Med, Beijing, Peoples R China 5.Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Wellcome Ctr Integrat Neuroimaging WIN, Oxford, England |
推荐引用方式 GB/T 7714 | Li, Hong,Li, Xiaoyun,Wang, Jiyuan,et al. Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia[J]. HUMAN BRAIN MAPPING,2022:13. |
APA | Li, Hong.,Li, Xiaoyun.,Wang, Jiyuan.,Gao, Fei.,Wiech, Katja.,...&Kong, Yazhuo.(2022).Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia.HUMAN BRAIN MAPPING,13. |
MLA | Li, Hong,et al."Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia".HUMAN BRAIN MAPPING (2022):13. |
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