Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways

doi:10.1016/j.biopha.2022.113269

	Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways
	Bian, Li-hua 1,3; Yao, Zi-wei 1; Wang, Zhe-yi 1,4; Wang, Xiao-mei 1; Li, Qiu-yu 1; Yang, Xue 1; Li, Jia-yuan 1; Wei, Xiao-jia 1; Wan, Guo-hui 1; Wang, Yu-qing 1; Shi, Jin-li 1; Guo, Jian-you2
第一作者	Li-hua Bian
通讯作者邮箱	cathybless@163.com (l.-h. bian) ; yaoziwei0000@163.com (z.-w. yao) ; zheyi91@126.com (z.-y. wang) ; 467115394@qq.com (x.-m. wang) ; 18166896895@163.com (q.-y. li) ; 1015190719@qq.com (x. yang) ; ljy15612930585@163.com (j.-y. li) ; 574013385@qq.com (x.-j. wei) ; chenxihui912@126.com (g.-h. wan) ; bucmwangyq@163.com (y.-q. wang) ; shijl@vip.sina.com (j.-l. shi) ; guojy@psych.ac.cn (j.-y. guo)
心理所单位排序	2
摘要	In a rotenone-induced Parkinson's disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed that the anti-PD target of nardosinone is the slc38a2 gene and may involve the GABAergic synaptic pathway and cAMP-signaling pathway. Analysis of targeted slc38a2 knockout cells and expression of key enzyme-encoding genes in both pathways verified the target and pathways proposed by the 'omics analysis. This further confirms that nardosinone can regulate the slc38a2 gene, a potential new target for the treatment of Parkinson's disease, and plays an anti-PD role through the GABAergic synaptic and cAMP pathways.
关键词	Parkinson?s disease Nardosinone slc38a2 GABAergic synaptic pathway
	2022-09-01
DOI	10.1016/j.biopha.2022.113269
发表期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
卷号	153 页码:17
期刊论文类型	综述
收录类别	SCI
资助项目	Institute of Psychology of the Chinese Academy of Sciences - Na-tional Natural Science Foundation of China[81673560] ; National Natural Science Foundation of China[81673560]
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS关键词	SUBSTANTIA-NIGRA ; NARDOSTACHYS-JATAMANSI ; INHIBITION ; DEGENERATION ; DOPAMINE ; NEURONS ; DISEASE ; PROTEIN
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:000815840900001
WOS分区	Q1
资助机构	Institute of Psychology of the Chinese Academy of Sciences - Na-tional Natural Science Foundation of China ; National Natural Science Foundation of China
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/42925
专题	中国科学院心理健康重点实验室
通讯作者	Shi, Jin-li; Guo, Jian-you
作者单位	1.Beijing Univ Chinese Med, Sch Chinese Mat Med, 11A North Third Ring East Rd, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A DatunRoad, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shandong Univ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Bian, Li-hua,Yao, Zi-wei,Wang, Zhe-yi,et al. Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:17.
APA	Bian, Li-hua.,Yao, Zi-wei.,Wang, Zhe-yi.,Wang, Xiao-mei.,Li, Qiu-yu.,...&Guo, Jian-you.(2022).Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways.BIOMEDICINE & PHARMACOTHERAPY,153,17.
MLA	Bian, Li-hua,et al."Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways".BIOMEDICINE & PHARMACOTHERAPY 153(2022):17.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Nardosinone regulate（11919KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	请求全文