Institutional Repository of Key Laboratory of Mental Health, CAS
| Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways | |
Bian, Li-hua1,3; Yao, Zi-wei1; Wang, Zhe-yi1,4; Wang, Xiao-mei1; Li, Qiu-yu1; Yang, Xue1; Li, Jia-yuan1; Wei, Xiao-jia1; Wan, Guo-hui1; Wang, Yu-qing1; Shi, Jin-li1; Guo, Jian-you2
| |
| 第一作者 | Li-hua Bian |
| 通讯作者邮箱 | cathybless@163.com (l.-h. bian) ; yaoziwei0000@163.com (z.-w. yao) ; zheyi91@126.com (z.-y. wang) ; 467115394@qq.com (x.-m. wang) ; 18166896895@163.com (q.-y. li) ; 1015190719@qq.com (x. yang) ; ljy15612930585@163.com (j.-y. li) ; 574013385@qq.com (x.-j. wei) ; chenxihui912@126.com (g.-h. wan) ; bucmwangyq@163.com (y.-q. wang) ; shijl@vip.sina.com (j.-l. shi) ; guojy@psych.ac.cn (j.-y. guo) |
| 心理所单位排序 | 2 |
| 摘要 | In a rotenone-induced Parkinson's disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed that the anti-PD target of nardosinone is the slc38a2 gene and may involve the GABAergic synaptic pathway and cAMP-signaling pathway. Analysis of targeted slc38a2 knockout cells and expression of key enzyme-encoding genes in both pathways verified the target and pathways proposed by the 'omics analysis. This further confirms that nardosinone can regulate the slc38a2 gene, a potential new target for the treatment of Parkinson's disease, and plays an anti-PD role through the GABAergic synaptic and cAMP pathways. |
| 关键词 | Parkinson?s disease Nardosinone slc38a2 GABAergic synaptic pathway |
| 2022-09-01 | |
| DOI | 10.1016/j.biopha.2022.113269 |
| 发表期刊 | BIOMEDICINE & PHARMACOTHERAPY
 |
| ISSN | 0753-3322 |
| 卷号 | 153页码:17 |
| 期刊论文类型 | 综述 |
| 收录类别 | SCI |
| 资助项目 | Institute of Psychology of the Chinese Academy of Sciences - Na-tional Natural Science Foundation of China[81673560] ; National Natural Science Foundation of China[81673560] |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS关键词 | SUBSTANTIA-NIGRA ; NARDOSTACHYS-JATAMANSI ; INHIBITION ; DEGENERATION ; DOPAMINE ; NEURONS ; DISEASE ; PROTEIN |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000815840900001 |
| WOS分区 | Q1 |
| 资助机构 | Institute of Psychology of the Chinese Academy of Sciences - Na-tional Natural Science Foundation of China ; National Natural Science Foundation of China |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/42925 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Shi, Jin-li; Guo, Jian-you |
| 作者单位 | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, 11A North Third Ring East Rd, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A DatunRoad, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shandong Univ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bian, Li-hua,Yao, Zi-wei,Wang, Zhe-yi,et al. Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:17. |
| APA | Bian, Li-hua.,Yao, Zi-wei.,Wang, Zhe-yi.,Wang, Xiao-mei.,Li, Qiu-yu.,...&Guo, Jian-you.(2022).Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways.BIOMEDICINE & PHARMACOTHERAPY,153,17. |
| MLA | Bian, Li-hua,et al."Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways".BIOMEDICINE & PHARMACOTHERAPY 153(2022):17. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Nardosinone regulate（11919KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论