Institutional Repository of Key Laboratory of Mental Health, CAS
Resting-state functional connectivity of salience network in schizophrenia and depression | |
Huang, Huan1; Chen, Cheng1; Rong, Bei1; Wan, Qirong1; Chen, Jingang2; Liu, Zhongchun1; Zhou, Yuan3; Wang, Gaohua1,4; Wang, Huiling1,2,5 | |
第一作者 | Huan Huang |
通讯作者邮箱 | hlwang@whu.edu.cn |
心理所单位排序 | 3 |
摘要 | To explore the salience network (SN) functional alterations in schizophrenia and depression, resting-state functional magnetic resonance imaging (rs-fMRI) data from 29 patients with schizophrenia (SCH), 28 patients with depression (DEP) and 30 healthy controls (HC) were obtained. The SN was derived from data-driven group independent component analysis (gICA). ANCOVA and post hoc tests were performed to discover the FC differences of SN between groups. The ANCOVA demonstrated a significant group effect in FC with right inferior and middle temporal gyrus (ITG and MTG), left caudate, and right precentral gyrus. Post-hoc analyses revealed an opposite altered FC pattern between SN and right ITG and MTG for both patient groups. The DEP group showed a reduced FC between SN and right ITG and MTG compared with HC whereas the SCH group showed an increased FC. In addition, the SCH group showed decreased FC between SN and left caudate, and enhanced FC between SN and right precentral gyrus compared to the other two groups. Our findings suggest distinct FC of SN in schizophrenia and depression, supporting that the resting-state FC pattern of SN may be a transdiagnostic difference between depression and schizophrenia and may play a critical role in the pathogenesis of these two disorders. |
2022-07-01 | |
语种 | 英语 |
DOI | 10.1038/s41598-022-15489-9 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 12期号:1页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Fundamental Research Funds for the Central Universities[2042020kf0128] ; Health Commission of Hubei Province scientific research project[WJ2021M142] ; Medical Science Advancement Program of Wuhan University[TFLC2018001] |
出版者 | NATURE PORTFOLIO |
WOS关键词 | DEFAULT-MODE NETWORK ; NAIVE PATIENTS ; PSYCHOSIS ; COMMON ; SYMPTOMATOLOGY ; CORTEX ; GYRUS ; RISK |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000819858600064 |
WOS分区 | Q2 |
资助机构 | Fundamental Research Funds for the Central Universities ; Health Commission of Hubei Province scientific research project ; Medical Science Advancement Program of Wuhan University |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/42934 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Huiling |
作者单位 | 1.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430060, Peoples R China 2.Wuhan Univ, Dept Psychiat, Zhongxiang Hosp, Renmin Hosp, Zhongxiang 431900, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 4.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Peoples R China 5.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China |
推荐引用方式 GB/T 7714 | Huang, Huan,Chen, Cheng,Rong, Bei,et al. Resting-state functional connectivity of salience network in schizophrenia and depression[J]. SCIENTIFIC REPORTS,2022,12(1):8. |
APA | Huang, Huan.,Chen, Cheng.,Rong, Bei.,Wan, Qirong.,Chen, Jingang.,...&Wang, Huiling.(2022).Resting-state functional connectivity of salience network in schizophrenia and depression.SCIENTIFIC REPORTS,12(1),8. |
MLA | Huang, Huan,et al."Resting-state functional connectivity of salience network in schizophrenia and depression".SCIENTIFIC REPORTS 12.1(2022):8. |
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