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Disruption of Functional Brain Networks Underlies the Handwriting Deficit in Children With Developmental Dyslexia | |
Liu, Zhengyan1,2; Li, Junjun1,2; Bi, Hong-Yan1,2; Xu, Min3; Yang, Yang1,2 | |
第一作者 | Zhengyan Liu |
通讯作者邮箱 | xumin@szu.edu.cn (min xu ) ; yangyang@psych.ac.cn (yang yang ) |
心理所单位排序 | 1 |
摘要 | Developmental dyslexia (DD) is a neurological-based learning disorder that affects 5-17.5% of children. Handwriting difficulty is a prevailing symptom of dyslexia, but its neural mechanisms remain elusive. Using functional magnetic resonance imaging (fMRI), this study examined functional brain networks associated with handwriting in a copying task in Chinese children with DD (n = 17) and age-matched children (n = 36) . We found that dyslexics showed reduced network connectivity between the sensory-motor network (SMN) and the visual network (VN), and between the default mode network (DMN) and the ventral attention network (VAN) during handwriting, but not during drawing geometric figures. Moreover, the connectivity strength of the networks showing group differences was correlated with handwriting speed, reading and working memory, suggesting that the handwriting deficit in DD is linked with disruption of a large-scale brain network supporting motoric, linguistic and executive control processes. Taken together, this study demonstrates the alternations of functional brain networks that underly the handwriting deficit in Chinese dyslexia, providing a new clue for the neural basis of DD. |
关键词 | developmental dyslexia handwriting fMRI functional brain network children |
2022-07-18 | |
语种 | 英语 |
DOI | 10.3389/fnins.2022.919440 |
发表期刊 | FRONTIERS IN NEUROSCIENCE |
卷号 | 16页码:12 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | DEFAULT MODE ; WHOLE-BRAIN ; CONNECTIVITY ; CHINESE ; METAANALYSIS ; LANGUAGE ; MOTOR ; REPRESENTATIONS ; ASSOCIATION ; ACTIVATION |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000834485500001 |
WOS分区 | Q2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/43054 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Xu, Min; Yang, Yang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Ctr Brain Sci & Learning Difficulties, CAS Key Lab Behav Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, Sch Psychol, Shenzhen, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Zhengyan,Li, Junjun,Bi, Hong-Yan,et al. Disruption of Functional Brain Networks Underlies the Handwriting Deficit in Children With Developmental Dyslexia[J]. FRONTIERS IN NEUROSCIENCE,2022,16:12. |
APA | Liu, Zhengyan,Li, Junjun,Bi, Hong-Yan,Xu, Min,&Yang, Yang.(2022).Disruption of Functional Brain Networks Underlies the Handwriting Deficit in Children With Developmental Dyslexia.FRONTIERS IN NEUROSCIENCE,16,12. |
MLA | Liu, Zhengyan,et al."Disruption of Functional Brain Networks Underlies the Handwriting Deficit in Children With Developmental Dyslexia".FRONTIERS IN NEUROSCIENCE 16(2022):12. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Disruption of Functi(1714KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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