Prevalence and related factors of anxiety in first episode and drug naive Chinese Han outpatients with psychotic major depression

doi:10.1016/j.jad.2022.08.018

PSYCH OpenIR

	Prevalence and related factors of anxiety in first episode and drug naive Chinese Han outpatients with psychotic major depression
	Zhou, Yanan 1,2; Wang, Qianjin 2; Ren, Honghong 2; Yang, Winson Fu Zun 3; Ma, Yuejiao 2; Wu, Qiuxia 2; Luo, Yinli 1; Yang, Dong 1; Liu, Tieqiao 2; Zhang, Xiangyang 4
通讯作者	Liu, Tieqiao(liutieqiao123@csu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Background: Anxiety frequently occurs with major depressive disorder (MDD) but to a different extent in the various subtypes. Psychotic major depression (PMD) is a severe subtype of MDD that is under-identified and under-studied. We investigated the prevalence and related risk factors of anxiety in PMD patients. Methods: A total of 1718 first episode and drug naive MDD patients were recruited. Measures included the Hamilton Depression Scale (HAMD), Clinical Global Impression-Severity scale (CGI-S), Hamilton Anxiety Scale (HAMA), and positive symptom scale of the Positive and Negative Syndrome Scale (PANSS), thyroid hormone levels, and metabolic parameters. Results: 171 of the entire MDD study sample met the criteria for the PMD subtype. The prevalence of severe anxiety was much higher in PMD patients (22.8 %) than in non-PMD patients (0.4 %) (chi 2 = 294.69, P < 0.001, OR = 75.88, 95 % CI = 31.55-182.52). Compared to PMD patients without severe anxiety, PMD patients with severe anxiety had higher HAMD score, CGI-S score, positive symptom subscale score, suicide attempts, blood pressure, thyroid-stimulating hormone (TSH), anti-thyroglobulin (TgAb), and thyroid peroxidases antibody (TPOAb) levels. Furthermore, logistic regression analysis indicated that HAMD score and TSH levels were associated with severe anxiety in PMD patients. Limitations: Our cross-sectional study cannot explain the causal relationship between anxiety severity and risk factors in PMD patients. Conclusions: Our results suggest that PMD patients are more likely to experience severe anxiety than non-PMD patients. The severity of depression and TSH levels are independent risk factors for anxiety in PMD patients.
关键词	Anxiety Depression Psychotic symptom Thyroid-stimulating hormone
	2022-11-01
语种	en
DOI	10.1016/j.jad.2022.08.018
发表期刊	JOURNAL OF AFFECTIVE DISORDERS
ISSN	0165-0327
卷号	316 页码:217-222
收录类别	SCI
资助项目	Shanxi Medical University ; Health and Family Planning Commission of Hunan Province Project[B20180484] ; Science and Technology Bureau, Changsha Project[kq2004106] ; Hunan Provincial Science and Technology Department project[2020SK2123] ; Hunan Provincial Science and Technology Department project[2021sk4022] ; Hunan Provincial Science and Technology Department project[2022sk2044] ; First Clinical Medical College
出版者	ELSEVIER
WOS关键词	ANXIOUS DEPRESSION ; CLINICAL CHARACTERISTICS ; NONANXIOUS DEPRESSION ; CO-MORBIDITY ; DISORDERS ; SEVERITY ; SYMPTOMS ; RISK ; DIFFERENCE ; PATTERNS
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:000848172100028
资助机构	Shanxi Medical University ; Health and Family Planning Commission of Hunan Province Project ; Science and Technology Bureau, Changsha Project ; Hunan Provincial Science and Technology Department project ; First Clinical Medical College
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/43393
通讯作者	Liu, Tieqiao; Zhang, Xiangyang
作者单位	1.Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Peoples R China 2.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 3.Texas Tech Univ, Coll Arts & Sci, Dept Psychol Sci, Lubbock, TX USA 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yanan,Wang, Qianjin,Ren, Honghong,et al. Prevalence and related factors of anxiety in first episode and drug naive Chinese Han outpatients with psychotic major depression[J]. JOURNAL OF AFFECTIVE DISORDERS,2022,316:217-222.
APA	Zhou, Yanan.,Wang, Qianjin.,Ren, Honghong.,Yang, Winson Fu Zun.,Ma, Yuejiao.,...&Zhang, Xiangyang.(2022).Prevalence and related factors of anxiety in first episode and drug naive Chinese Han outpatients with psychotic major depression.JOURNAL OF AFFECTIVE DISORDERS,316,217-222.
MLA	Zhou, Yanan,et al."Prevalence and related factors of anxiety in first episode and drug naive Chinese Han outpatients with psychotic major depression".JOURNAL OF AFFECTIVE DISORDERS 316(2022):217-222.