PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Alternative TitleThe Roles of OrexinⅠReceptor in Ventral Tegmental Area and Nucleus Accumbens in Drug-seeking Behavior Induced by Morphine
白云静; 黄砚北; 魏楚光; 彭永华; 李勇辉; 隋南
Source Publication中国心理卫生杂志
Keyword药物成瘾 条件性位置偏爱 食欲素 觅药行为 中脑腹侧被盖区 伏隔核
Subject Area生理心理学/生物心理学
Funding Project国家重点基础研究发展计划(973计划)(2003CB515404,2009CB522002);;国家自然科学基金(30770719,30600184);;中国科学院知识创新工程重要方向项目(KSCX1-TW-R-68)
NoteObjective:To investigate the roles of OXR1 in the ventral tegmental area(VTA)and nucleus accumbens(NAc)in drug-seeking behavior induced by morphine.Methods:Drug-seeking behavior in rats was measured with the model of expression of morphine conditioned place preference(CPP).Eighty-eight male Wistar rats were randomly incorporated into the VTA-treated groups and NAc-treated groups.The OXR1 selective antagonist SB334867(VTA:1,5μg; NAc:1,3μg)or vehicle(Dmethyl Sulfoxide)were microinjected into the VTA and NAc respectively before CPP expression tests.The one-way ANOVA was used to compare the preference scores among groups.Results:The preference score was significantly reduced in animals microinjected with 5μg SB334867 compared with that in animals microinjected with vehicle into the VTA before CPP expression test [(73.6±81.7)vs.(183.5±30.4),P<0.05]; There was no significant difference between the preference score in animals microinjected with SB334867(229.6±72.9 and 260.6±53.9)and that in animals microinjected with vehicle(224±52.1)into the NAc before CPP expression test.Conclusion:The activation of OXR1 in the VTA plays an important role in drug-seeking behavior elicited by morphine-associated environmental cues,while OXR1 in the NAc is not involved in this behavior.The present study suggests some neural mechanisms underlying the roles of orexins in drug-seeking behavior.
Document Type期刊论文
Corresponding Author隋南
Recommended Citation
GB/T 7714
白云静,黄砚北,魏楚光,等. 中脑腹侧被盖区和伏隔核内食欲素Ⅰ型受体在大鼠觅药行为表达中的作用[J]. 中国心理卫生杂志,2009,23(6):441-445.
APA 白云静,黄砚北,魏楚光,彭永华,李勇辉,&隋南.(2009).中脑腹侧被盖区和伏隔核内食欲素Ⅰ型受体在大鼠觅药行为表达中的作用.中国心理卫生杂志,23(6),441-445.
MLA 白云静,et al."中脑腹侧被盖区和伏隔核内食欲素Ⅰ型受体在大鼠觅药行为表达中的作用".中国心理卫生杂志 23.6(2009):441-445.
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