Institutional Repository of Key Laboratory of Behavioral Science, CAS
Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder | |
Lv, Dan1; Ou, Yangpan2,3; Chen, Yunhui1; Ding, Zhenning1; Ma, Jidong4; Zhan, Chuang4; Yang, Ru5; Shang, Tinghuizi1; Zhang, Guangfeng6; Bai, Xiaoyu7,8; Sun, Zhenghai1; Xiao, Jian1; Wang, Xiaoping2,3; Guo, Wenbin2,3; Li, Ping1 | |
通讯作者邮箱 | guowenbin76@csu.edu.cn (wenbin guo) ; lipingchxyy@163.com(ping li) |
心理所单位排序 | 7 |
摘要 | Background Brain functional abnormalities at rest have been observed in obsessive-compulsive disorder (OCD). However, whether and how anatomical distance influences functional connectivity (FC) at rest is ambiguous in OCD. Methods Using resting-state functional magnetic resonance imaging data, we calculated the FC of each voxel in the whole-brain and divided FC into short- and long-range FCs in 40 medicine-free patients with OCD and 40 healthy controls (HCs). A support vector machine (SVM) was used to determine whether the altered short- and long-range FCs could be utilized to distinguish OCD from HCs. Results Patients had lower short-range positive FC (spFC) and long-range positive FC (lpFC) in the left precentral/postcentral gyrus (t = -5.57 and -5.43; P < 0.05, GRF corrected) and higher lpFC in the right thalamus/caudate, left thalamus, left inferior parietal lobule (IPL) and left cerebellum CrusI/VI (t = 4.59, 4.61, 4.41, and 5.93; P < 0.05, GRF corrected). Furthermore, lower spFC in the left precentral/postcentral gyrus might be used to distinguish OCD from HCs with an accuracy of 80.77%, a specificity of 81.58%, and a sensitivity of 80.00%. Conclusion These findings highlight that anatomical distance has an effect on the whole-brain FC patterns at rest in OCD. Meanwhile, lower spFC in the left precentral/postcentral gyrus might be applied in distinguishing OCD from HCs. |
关键词 | obsessive-compulsive disorder Anatomical distance Short-range Long-range Functional connectivity |
2022-10-12 | |
语种 | 英语 |
DOI | 10.1186/s12888-022-04103-x |
发表期刊 | BMC PSYCHIATRY |
卷号 | 22期号:1页码:10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Qiqihar Academy of Medical Sciences Project[QMSI2021M-07] ; Natural Science Foundation of Heilongjiang Province, China[LH2019H064] |
出版者 | BMC |
WOS关键词 | SHORT-RANGE ; NAIVE SCHIZOPHRENIA ; 1ST-EPISODE ; NETWORKS ; CORTEX |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000866109500001 |
WOS分区 | Q2 |
资助机构 | Qiqihar Academy of Medical Sciences Project ; Natural Science Foundation of Heilongjiang Province, China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/43514 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Guo, Wenbin; Li, Ping |
作者单位 | 1.Qiqihar Med Univ, Dept Psychiat, Qiqihar, Peoples R China 2.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China 3.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Peoples R China 4.Baiyupao Psychiat Hosp Harbin, Dept Psychiat, Harbin, Peoples R China 5.Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha, Peoples R China 6.Qiqihar Med Univ, Dept Radiol, Affiliated Hosp 3, Qiqihar, Peoples R China 7.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Lv, Dan,Ou, Yangpan,Chen, Yunhui,et al. Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder[J]. BMC PSYCHIATRY,2022,22(1):10. |
APA | Lv, Dan.,Ou, Yangpan.,Chen, Yunhui.,Ding, Zhenning.,Ma, Jidong.,...&Li, Ping.(2022).Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder.BMC PSYCHIATRY,22(1),10. |
MLA | Lv, Dan,et al."Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder".BMC PSYCHIATRY 22.1(2022):10. |
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