Institutional Repository of Key Laboratory of Mental Health, CAS
Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients | |
Huang, Zetao1; Ruan, Dun2,3; Huang, Bingjie1; Zhou, Tianhang1; Shi, Chuan1; Yu, Xin1; Chan, Raymond C. K.2,3; Wang, Yi2,3; Pu, Chengcheng1 | |
第一作者 | Zetao Huang |
通讯作者邮箱 | pciami@163.com (chengcheng pu ) ; wangyi@psych.ac.cn (y. wang) |
心理所单位排序 | 2 |
摘要 | Negative symptoms play an important role in development and treatment of schizophrenia. However, brain changes relevant to negative symptoms are still unclear. This study examined brain structural abnormalities and their asymmetry in schizophrenia patients and the association with negative symptoms. Fifty-nine schizophrenia patients and 66 healthy controls undertook structural brain scans. Schizophrenia patients were further divided into predominant negative symptoms (PNS, n = 18) and non-PNS (n = 34) subgroups. Negative symptoms were assessed by the Negative Symptom Assessment (NSA). T1-weighted images were preprocessed with FreeSurfer to estimate subcortical volumes, cortical thickness and surface areas, asymmetry Index (AI) was then calculated. MANOVA was performed for group differences while partial correlations in patients were analyzed between altered brain structures and negative symptoms. Compared to healthy controls, schizophrenia patients exhibited thinner cortices in frontal and temporal regions, and decreased leftward asymmetry of superior temporal gyrus (STG) in cortical thickness. Patients with PNS exhibited increased rightward asymmetry of amygdala volumes than non-PNS subgroup. In patients, AI of cortical thickness in the STG was negatively correlated with NSA-Emotion scores (r = -0.30, p = 0.035), while AI of amygdala volume was negatively correlated with NSA-Communication (r = -0.30, p = 0.039) and NSA-Total scores (r = -0.30, p = 0.038). Our findings suggested schizophrenia patients exhibited cortical thinning and altered lateralization of brain structures. Emotion and communication dimensions of negative symptoms also correlated with the structural asymmetry of amygdala and superior temporal regions in schizophrenia patients. |
关键词 | schizophrenia predominantly negative symptoms cortical thickness asymmetry amygdala |
2022-09-26 | |
语种 | 英语 |
DOI | 10.3389/fpsyt.2022.1000560 |
发表期刊 | FRONTIERS IN PSYCHIATRY |
ISSN | 1664-0640 |
卷号 | 13页码:9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | HUMAN CEREBRAL-CORTEX ; HEMISPHERIC ASYMMETRIES ; CORTICAL THICKNESS ; SURFACE-AREA ; RECOGNITION ; EMOTION ; VOLUME ; VALIDATION ; GYRUS ; MRI |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000866462700001 |
WOS分区 | Q2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/43520 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Yi; Pu, Chengcheng |
作者单位 | 1.Peking Univ, Peking Univ Hosp 6, Peking Univ Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clic Res Ctr Mental D, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Huang, Zetao,Ruan, Dun,Huang, Bingjie,et al. Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients[J]. FRONTIERS IN PSYCHIATRY,2022,13:9. |
APA | Huang, Zetao.,Ruan, Dun.,Huang, Bingjie.,Zhou, Tianhang.,Shi, Chuan.,...&Pu, Chengcheng.(2022).Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients.FRONTIERS IN PSYCHIATRY,13,9. |
MLA | Huang, Zetao,et al."Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients".FRONTIERS IN PSYCHIATRY 13(2022):9. |
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