The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients

doi:10.3389/fpsyt.2022.993859

PSYCH OpenIR

	The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients
	Xu, Hang 1; Zhou, Yongjie 2; Xiu, Meihong 3; Chen, Dachun 3; Wang, Weiwen 1,4; Wang, Li 1,4; Zhang, Xiangyang 1,4
通讯作者	Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	ObjectiveSchizophrenia is a multifaceted mental disorder characterized by heterogeneous positive/negative symptoms and cognitive deficits. Sex differences have been reported in various aspects of the disease. However, the underlying genetic reasons remain unelucidated. Recent studies show that the influence of COMT Val158Met (rs4680) variation is sexually dimorphic. Thus, this study aims to explore whether there is an effect of the interaction between COMT Val158Met (rs4680) polymorphism and sex on patients' clinical characteristics and cognitive function. Materials and methodsWe recruited 367 in patients with chronic schizophrenia (246 males and 121 females) and 419 healthy controls (172 males and 247 females). The cognitive performance was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the COMT Val158Met (rs4680) polymorphism is genotyped. The psychopathological symptoms of the patients were assessed by the Positive and Negative Syndrome Scale (PANSS). ResultsWe find that male patients had a significantly higher proportion of carrying the Val allele and Val/Val carriers exhibited more severe positive symptoms and cognitive impairment than Met carriers. COMT Val158Met (rs4680) polymorphism inconsistently mediated the relationship between sex and cognitive performance in schizophrenia patients. ConclusionThese findings suggest that COMT Val158Met (rs4680) polymorphism is associated with the risk and severity of schizophrenia in a sexually dimorphic way and contributes more to the clinical symptoms and cognitive impairment in male patients with schizophrenia.
关键词	schizophrenia catechol-O-methyl transferase (COMT) Val158Met (rs4680) sex difference cognitive function
	2022-09-20
语种	英语
DOI	10.3389/fpsyt.2022.993859
发表期刊	FRONTIERS IN PSYCHIATRY
ISSN	1664-0640
卷号	13 页码:10
收录类别	SCI
资助项目	National Natural Science Foundation of China ; China Postdoctoral Science Foundation[81371477] ; China Postdoctoral Science Foundation[82071517] ; China Postdoctoral Science Foundation[U21A20364] ; China Postdoctoral Science Foundation[31771217] ; Special Research Assistant Program of CAS[E0BH0110] ; Chinese Academy of Sciences[E0ZZ0210] ; Key Laboratory of Mental Health, Institute of Psychology
出版者	FRONTIERS MEDIA SA
WOS关键词	COMT VAL158MET POLYMORPHISM ; METHYLTRANSFERASE GENE ; NEGATIVE SYMPTOMS ; ASSOCIATION ; GENOTYPE ; GENDER ; RISK ; POPULATION ; METABOLISM ; DOPAMINE
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000863724200001
资助机构	National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Special Research Assistant Program of CAS ; Chinese Academy of Sciences ; Key Laboratory of Mental Health, Institute of Psychology
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/43601
通讯作者	Zhang, Xiangyang
作者单位	1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, Shenzhen, Guangdong, Peoples R China 3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xu, Hang,Zhou, Yongjie,Xiu, Meihong,et al. The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients[J]. FRONTIERS IN PSYCHIATRY,2022,13:10.
APA	Xu, Hang.,Zhou, Yongjie.,Xiu, Meihong.,Chen, Dachun.,Wang, Weiwen.,...&Zhang, Xiangyang.(2022).The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients.FRONTIERS IN PSYCHIATRY,13,10.
MLA	Xu, Hang,et al."The inconsistent mediating effect of catechol O methyl transferase Val(158)Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients".FRONTIERS IN PSYCHIATRY 13(2022):10.