Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats

	Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats
	Lv, Qin 1; Di, Xiaoyan 2; Bian, Bo 3; Li, Kai 4; Guo, Jianyou5,6
通讯作者	Guo, Jianyou(guojianyou@126.com)
摘要	Alzheimer's disease (AD) is a neurodegenerative disease that has become a leading cause of death in recent years. The present study aimed to explore the possible prophylactic effects of Poria cocos essential oil (PCEO) against memory deficits in A beta rats. Adult male Wistar rats were given A beta 1-42 via ICV injection. The effect of 30 d administration of PCEO by oral gavage was investigated. Novel object recognition (NOR) test, Morris water maze (MWM) test, and passive avoidance memory retention (PAM) task were performed. AP decreased the cognitive memory in NOR, spatial memory in MWM, and passive avoidance memory in PAM tests. In contrast, PCEO improved learning and memory in the treated group. The PCEO treatment halts the activity of AChE in the hippocampus and cortex of the AD rats. The central neuronal degeneration in A beta-injected rats was not only ascertained by the histopathological changes but also confirmed indirectly by the concomitant increase in GFAP immunostaining. The beneficial effects in AD of increasing cellular GPx, GR, CAT, Na+ K+ ATPase and GST through the administration of PCEO may not only result in protection against neurodegeneration but also result in improvement in cognitive function. PCEO may be recommended as a prophylactic and/or adjunct medication for neurodegenerative diseases.
关键词	Alzheimer's disease Poria cocos seed oil novel object recognition Morris water maze passive avoidance memory retention medicinal mushrooms
	2022
语种	英语
发表期刊	INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
ISSN	1521-9437
卷号	24 期号:10 页码:73-82
收录类别	SCI
出版者	BEGELL HOUSE INC
WOS关键词	MEDICINAL MUSHROOM ; METHYL JASMONATE ; CLONING ; STRESS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy
WOS记录号	WOS:000860556500001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/43629
专题	中国科学院心理健康重点实验室
通讯作者	Guo, Jianyou
作者单位	1.NanYang Med Coll, Dept Chinese Med, Nanyang 473061, Peoples R China 2.Beijing Univ Chem Technol, Beijing 100029, Peoples R China 3.Nanyang Inst Technol, Zhang Zhongjing Coll Chinese Med, Nanyang 473004, Peoples R China 4.Nanyang Inst Technol, Henan Key Lab Zhang Zhongjing Formulae & Herbs Imm, Nanyang 473004, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Lv, Qin,Di, Xiaoyan,Bian, Bo,et al. Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2022,24(10):73-82.
APA	Lv, Qin,Di, Xiaoyan,Bian, Bo,Li, Kai,&Guo, Jianyou.(2022).Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,24(10),73-82.
MLA	Lv, Qin,et al."Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A beta 1-40 Induced Learning and Memory Deficit in Rats".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 24.10(2022):73-82.