Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression

doi:10.1016/j.parkreldis.2022.08.020

PSYCH OpenIR

	Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression
	Wang, Yu 1; Bai, Li -Peng 1; Liu, Wei 1; Zhu, Xiao-Dong 1; Zhang, Xiang -Yang 2,3,4
通讯作者	Zhang, Xiang -Yang(zhangxy@psych.ac.cn)
摘要	Objective: Depression and cognitive impairment are both common non-motor symptoms of Parkinson's disease (PD). Brain-derived neurotrophic factor (BDNF) may play an important role in both cognitive function and depression. In this study, we examined BDNF levels, cognitive function, and the relationship between BDNF and cognitive function in PD patients with and without depressive symptoms, which has not been reported yet.Methods: We recruited 96 PD patients with (n = 46) and without depression (n = 50) and 102 controls and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and BDNF levels in all groups. The Zung Self-Rating Depression Scale (SDS) was used to assess the severity of depression and the Hoehn-Yahr staging test was used to assess motor abilities in PD patients.Results: BDNF levels were lower in patients with depressive symptoms than in patients without depressive symptoms (p < 0.01). The RBANS total score and the immediate memory, language and attention scores were lower in patients with depressive than in patients without depressive (all p < 0.05). Multiple regression analysis showed that BDNF was independent contributor to immediate memory, language and RBANS total score in the patients with depressive symptoms. BDNF and SDS were independent contributors to attention, and SDS was an independent contributor to delay memory (all p < 0.001).Conclusions: BDNF may be involved in the pathophysiology of PD patients with depressive symptoms. Moreover, the association between BDNF and cognitive performance only in patients with depressive symptoms suggest a close relationship in BDNF, cognition and depressive symptoms in PD patients.
关键词	Parkinson?s disease Depression BDNF Cognition
	2022-10-01
语种	英语
DOI	10.1016/j.parkreldis.2022.08.020
发表期刊	PARKINSONISM & RELATED DISORDERS
ISSN	1353-8020
卷号	103 页码:122-128
收录类别	SCI
资助项目	National Science Foundation of Tianjin[17JCYBJC28100] ; National Science Foundation of Tianjin[19JCYBJC26100]
出版者	ELSEVIER SCI LTD
WOS关键词	VAL66MET POLYMORPHISM ; CSF ; PLASTICITY
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology
WOS记录号	WOS:000860362600002
资助机构	National Science Foundation of Tianjin
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/43636
通讯作者	Zhang, Xiang -Yang
作者单位	1.Tianjin Med Univ, Dept Neurol, Gen Hosp, Tianjin, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yu,Bai, Li -Peng,Liu, Wei,et al. Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression[J]. PARKINSONISM & RELATED DISORDERS,2022,103:122-128.
APA	Wang, Yu,Bai, Li -Peng,Liu, Wei,Zhu, Xiao-Dong,&Zhang, Xiang -Yang.(2022).Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression.PARKINSONISM & RELATED DISORDERS,103,122-128.
MLA	Wang, Yu,et al."Altered BDNF levels are associated with cognitive impairment in Parkinson?s disease patients with depression".PARKINSONISM & RELATED DISORDERS 103(2022):122-128.