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Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome
Canete-Masse, Cristina1,2; Carbo-Carrete, Maria3,4; Pero-Cebollero, Maribel1,2,4; Cui, Shi-Xian5,6,7,8; Yan, Chao-Gan5,6,7,8; Guardia-Olmos, Joan1,2,4
第一作者Cristina Cañete‑Massé
通讯作者邮箱cristinacanete@ub.edu (cristina cañete‑massé)
心理所单位排序5
摘要

Although Down syndrome (DS) is the most common genetic cause of neurodevelopmental delay, few neuroimaging studies have explored this population. This investigation aimed to study whole-brain resting-state spontaneous brain activity using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) strategies to find differences in spontaneous brain activity among young people with DS and controls and to correlate these results with cognitive outcomes. The sample comprised 18 persons with DS (age mean = 28.67, standard deviation =4.18) and 18 controls (age mean= 28.56, standard deviation = 4.26). fALFF and ReHo analyses were performed, and the results were correlated with other cognitive variables also collected (KBIT-2 and verbal fluency test). Increased activity was found in DS using fALFF in areas involving the frontal and temporal lobes and left cerebellum anterior lobe. Decreased activity in DS was found in the left parietal and occipital lobe, the left limbic lobe and the left cerebellum posterior lobe. ReHo analysis showed increased activity in certain DS areas of the left frontal lobe and left rectus, as well as the inferior temporal lobe. The areas with decreased activity in the DS participants were regions of the frontal lobe and the right limbic lobe. Altered fALFF and ReHo were found in the DS population, and this alteration could predict the cognitive abilities of the participants. To our knowledge, this is the first study to explore regional spontaneous brain activity in a population with DS. Moreover, this study suggests the possibility of using fALFF and ReHo as biomarkers of cognitive function, which is highly important given the difficulties in cognitively evaluating this population to assess dementia. More research is needed, however, to demonstrate its utility.

2022-09-14
语种英语
DOI10.1038/s41598-022-19627-1
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号12期号:1页码:12
期刊论文类型实证研究
收录类别SCI
资助项目Spanish Ministry of Science, Innovation and Universities[PGC2018-095829-B-I00]
出版者NATURE PORTFOLIO
WOS关键词STATE FUNCTIONAL CONNECTIVITY ; NONDEMENTED ADULTS ; ALZHEIMERS-DISEASE ; MOTION CORRECTION ; INTRINSIC BRAIN ; FLUCTUATION ; AMPLITUDE ; FMRI ; AGE ; STRATEGIES
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000853934100062
WOS分区Q2
资助机构Spanish Ministry of Science, Innovation and Universities
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/43662
专题中国科学院行为科学重点实验室
通讯作者Canete-Masse, Cristina
作者单位1.Univ Barcelona, Fac Psychol, Dept Social Psychol & Quantitat Psychol, Barcelona, Spain
2.Univ Barcelona, UB Inst Complex Syst, Barcelona, Spain
3.Univ Barcelona, Fac Psychol, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
4.Univ Barcelona, Inst Neurosci, Barcelona, Spain
5.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Int Big Data Ctr Depress Res, Beijing, Peoples R China
7.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
8.Univ Chinese Acad Sci, Sino Danish Coll, Sino Danish Ctr Educ & Res, Beijing, Peoples R China
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GB/T 7714
Canete-Masse, Cristina,Carbo-Carrete, Maria,Pero-Cebollero, Maribel,et al. Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome[J]. SCIENTIFIC REPORTS,2022,12(1):12.
APA Canete-Masse, Cristina,Carbo-Carrete, Maria,Pero-Cebollero, Maribel,Cui, Shi-Xian,Yan, Chao-Gan,&Guardia-Olmos, Joan.(2022).Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome.SCIENTIFIC REPORTS,12(1),12.
MLA Canete-Masse, Cristina,et al."Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome".SCIENTIFIC REPORTS 12.1(2022):12.
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