Responses of Chemosensory Perception to Stimulation of the Human Brain

doi:10.1002/ana.26532

PSYCH OpenIR

	Responses of Chemosensory Perception to Stimulation of the Human Brain
	Li, Yanyan 1,2; Tan, Zheng 1,2; Wang, Jing 3; Cai, Yufei 1,2; Wang, Mengyang 3; Zhou, Wen 1,2; Wang, Liang 1,2
通讯作者	Wang, Liang(lwang@psych.ac.cn)
摘要	Objective Significant advances have been made in our understanding of the neural substrates of human chemosensory processing, involving the piriform cortex, insula, and orbitofrontal cortex. However, the important and challenging issues are to localize the brain regions with high anatomic precision that can causally produce chemosensory perception and further delineate the topography of different classifications of chemosensory perception. Methods We quantitatively measured subjective responses of chemosensory perception to intracranial electrical stimulation over the brain in neurosurgical patients (n = 302) with medically refractory epilepsy. Results The chemosensory perceptions including olfaction, gustation, and chemesthesis were elicited in 21 of 302 patients (7%). Chemosensory responses were evoked in 53 (0.2%) of 21,661 stimulated sites. The highest response rate (1.8%) was in the insula (37/2,051 stimulated sites from 15/163 patients). The chemosensory perception emerged predominantly during stimulation of the insula along the central sulcus axis. Notably, there existed a distinct pattern that the anteroventral insula predominately represented orthonasal olfaction, whereas different chemosensory modalities converged in the mid-dorsal insula. Interpretation This study provided a detailed characterization of chemosensory perception across the brain, especially in the insula. These results suggest that the cortex along the banks of the central sulcus of the insula may play a role in producing the supramodal sensation of flavor. It also indicates that dysfunction of the central insula should be considered during the evaluation of chemosensory-related epileptic seizures. ANN NEUROL 2022
	2022-10-25
语种	英语
DOI	10.1002/ana.26532
发表期刊	ANNALS OF NEUROLOGY
ISSN	0364-5134
页码	9
收录类别	SCI
资助项目	National Science and Technology Innovation 2030 Major Program[2022ZD0205000] ; National Natural Science Foundation of China[32020103009] ; National Natural Science Foundation of China[31500923] ; National Natural Science Foundation of China[31771255] ; Ministry Key Project[GW089000] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences[E2CX4215CX] ; Sanbo Brain Hospital, Capital Medical University[2021ZZLX02]
出版者	WILEY
WOS关键词	ORBITOFRONTAL CORTEX ; INSULAR CORTEX ; LOBE ; SEIZURES ; HALLUCINATIONS ; ORTHONASAL ; ACTIVATION ; FLAVOR
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:000871416200001
资助机构	National Science and Technology Innovation 2030 Major Program ; National Natural Science Foundation of China ; Ministry Key Project ; CAS Interdisciplinary Innovation Team ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Sanbo Brain Hospital, Capital Medical University
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/43822
通讯作者	Wang, Liang
作者单位	1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Capital Med Univ, Sanbo Brain Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Yanyan,Tan, Zheng,Wang, Jing,et al. Responses of Chemosensory Perception to Stimulation of the Human Brain[J]. ANNALS OF NEUROLOGY,2022:9.
APA	Li, Yanyan.,Tan, Zheng.,Wang, Jing.,Cai, Yufei.,Wang, Mengyang.,...&Wang, Liang.(2022).Responses of Chemosensory Perception to Stimulation of the Human Brain.ANNALS OF NEUROLOGY,9.
MLA	Li, Yanyan,et al."Responses of Chemosensory Perception to Stimulation of the Human Brain".ANNALS OF NEUROLOGY (2022):9.