Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction

doi:10.1038/s41386-022-01477-0

	Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction
	Dai, Zhonghua 1,2; Liu, Ying1,2 ; Nie, Lina 1,2; Chen, Weiqi 1,2,3; Xu, Xing1,2 ; Li, Yonghui1,2,3 ; Zhang, Jianjun1,2 ; Shen, Fang1,2 ; Sui, Nan1,2 ; Liang, Jing1,2,3
通讯作者	Liang, Jing(liangj@psych.ac.cn)
摘要	Extinction training during the reconsolidation window following memory recall is an effective behavioral pattern for promoting the extinction of pathological memory. However, promoted extinction by recall-extinction procedure has not been universally replicated in different studies. One potential reason for this may relate to whether initially acquired memory is successfully activated. Thus, the methods for inducing the memory into an active or plastic condition may contribute to promoting its extinction. The aim of this study is to find and demonstrate a manipulatable neural circuit that engages in the memory recall process and where its activation improves the extinction process through recall-extinction procedure. Here, naloxone-precipitated conditioned place aversion (CPA) in morphine-dependent mice was mainly used as a pathological memory model. We found that the locus coeruleus (LC)-dentate gyrus (DG) circuit was necessary for CPA memory recall and that artificial activation of LC inputs to the DG just prior to initiating a recall-extinction procedure significantly promoted extinction learning. We also found that activating this circuit caused an increase in the ensemble size of DG engram cells activated during the extinction, which was confirmed by a cFos targeted strategy to label cells combined with immunohistochemical and in vivo calcium imaging techniques. Collectively, our data uncover that the recall experience is important for updating the memory during the reconsolidation window; they also suggest a promising neural circuit or target based on the recall-extinction procedure for weakening pathological aversion memory, such as opioid withdrawal memory and fear memory.
	2022-10-27
语种	英语
DOI	10.1038/s41386-022-01477-0
发表期刊	NEUROPSYCHOPHARMACOLOGY
ISSN	0893-133X
页码	14
收录类别	SCI
资助项目	National Natural Science Foundation of China[32071028] ; Natural Science Foundation of Beijing Municipality[5202023] ; CAS-VPST Silk Road Science Fund 2021[GJHZ202129]
出版者	SPRINGERNATURE
WOS关键词	POST-RETRIEVAL EXTINCTION ; CONDITIONED PLACE AVERSION ; PATTERN SEPARATION ; FEAR EXTINCTION ; MEMORY ; RECONSOLIDATION ; NEURONS ; NOREPINEPHRINE ; NORADRENALINE ; CONSOLIDATION
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000874397600002
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; CAS-VPST Silk Road Science Fund 2021
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/43874
专题	中国科学院心理健康重点实验室
通讯作者	Liang, Jing
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Dai, Zhonghua,Liu, Ying,Nie, Lina,et al. Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction[J]. NEUROPSYCHOPHARMACOLOGY,2022:14.
APA	Dai, Zhonghua.,Liu, Ying.,Nie, Lina.,Chen, Weiqi.,Xu, Xing.,...&Liang, Jing.(2022).Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction.NEUROPSYCHOPHARMACOLOGY,14.
MLA	Dai, Zhonghua,et al."Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction".NEUROPSYCHOPHARMACOLOGY (2022):14.

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