Institutional Repository of Key Laboratory of Mental Health, CAS
Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection | |
Wang, Siqi1,2; Bian, Lihua2,3; Yin, Yi1,2; Guo, Jianyou1,2 | |
第一作者 | Siqi Wang |
通讯作者邮箱 | guojy@psych.ac.cn ( jianyou guo) |
心理所单位排序 | 1 |
摘要 | Excitatory glutamatergic neurotransmission mediated through N-methyl-D-Aspartate (NMDA) receptors (NMDARs) is essential for synaptic plasticity and neuronal survival. While under pathological states, abnormal NMDAR activation is involved in the occurrence and development of psychiatric disorders, which suggests a directional modulation of NMDAR activity that contributes to the remission and treatment of psychiatric disorders. This review thus focuses on the involvement of NMDARs in the pathophysiological processes of psychiatric mood disorders and analyzes the neuroprotective mechanisms of NMDARs. Firstly, we introduce NMDAR-mediated neural signaling pathways in brain function and mood regulation as well as the pathophysiological mechanisms of NMDARs in emotion-related mental disorders such as anxiety and depression. Then, we provide an in-depth summary of current NMDAR modulators that have the potential to be developed into clinical drugs and their pharmacological research achievements in the treatment of anxiety and depression. Based on these findings, drug-targeting for NMDARs might open up novel territory for the development of therapeutic agents for refractory anxiety and depression. |
关键词 | NMDAR depression anxiety neuroprotection |
2022-10-01 | |
语种 | 英语 |
DOI | 10.3390/brainsci12101329 |
发表期刊 | BRAIN SCIENCES |
卷号 | 12期号:10页码:17 |
期刊论文类型 | 综述 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[82073971] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX] |
出版者 | MDPI |
WOS关键词 | D-ASPARTATE RECEPTOR ; PROOF-OF-CONCEPT ; TREATMENT-RESISTANT DEPRESSION ; FUNCTIONAL PARTIAL AGONIST ; LONG-TERM POTENTIATION ; GLUTAMATE RECEPTORS ; MAJOR DEPRESSION ; RANDOMIZED-TRIAL ; CELL-DEATH ; SYNAPTIC PLASTICITY |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000875956300001 |
WOS分区 | Q3 |
资助机构 | National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/43886 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Guo, Jianyou |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Siqi,Bian, Lihua,Yin, Yi,et al. Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection[J]. BRAIN SCIENCES,2022,12(10):17. |
APA | Wang, Siqi,Bian, Lihua,Yin, Yi,&Guo, Jianyou.(2022).Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection.BRAIN SCIENCES,12(10),17. |
MLA | Wang, Siqi,et al."Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection".BRAIN SCIENCES 12.10(2022):17. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Targeting NMDA Recep(533KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论