Institutional Repository of Key Laboratory of Mental Health, CAS
Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia | |
Chen, Pinhong1; Wang, Dongmei2,3; Xiu, Meihong4; Chen, Dachun4; Lackey, Blake5; Wu, Hanjing E.5; Wang, Lubin1; Zhang, Xiangyang2,3 | |
第一作者 | Pinhong Chen |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. yang zhang). |
摘要 | A large amount of recent literature has focused on impaired iron homeostasis in the pathophysiology of schizophrenia. Specifically, microarray analysis has illustrated associations between the transferrin locus and schizophrenia. To elaborate on the effects of transferrin on schizophrenia and its psychiatric phenotypes, our study aimed to investigate whether transferrin gene polymorphism was correlated with cognitive deficits and clinical symptoms in schizophrenia. We recruited 564 patients with chronic schizophrenia and 422 healthy controls (HCs) in a Han Chinese population, collected phenotypic data, and genotyped the rs3811655 polymorphism of the transferrin gene. Our results showed that the rs3811655 polymorphism was related to cognitive performance in both patients and HCs, as well as negative symptoms in patients (all p < 0.05), and patients carrying at least one G-allele showed worsened cognition/severe negative symptoms (all p < 0.05). Further analyses also found that the rs3811655 polymorphism in combination with cognition may exert small but significant contributions to the negative (beta = -0.10, t = -2.48, p < 0.05) or total psychiatric symptoms (beta = -0.08, t = -1.92, p < 0.05) in patients. Our findings indicated that the rs3811655 polymorphism may be implicated in the cognitive deficits of schizophrenia and HCs as well as psychiatric symptoms in patients, which suggested the possible iron regulatory mechanism in the pathology of schizophrenia. |
关键词 | transferrin genetic polymorphism psychiatric symptoms cognitive deficits schizophrenia |
2022-11-01 | |
语种 | 英语 |
DOI | 10.3390/jcm11216414 |
发表期刊 | JOURNAL OF CLINICAL MEDICINE |
卷号 | 11期号:21页码:12 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[61673391] ; Psychosis project of the Beijing Key Laboratory[Z161100002616017] ; CAS International Cooperation Research Program[153111KYSB20190004] |
出版者 | MDPI |
WOS关键词 | IRON-DEFICIENCY ; SERUM IRON ; EXPRESSION ; BEHAVIOR ; MARKERS |
WOS研究方向 | General & Internal Medicine |
WOS类目 | Medicine, General & Internal |
WOS记录号 | WOS:000881170500001 |
WOS分区 | Q2 |
资助机构 | National Natural Science Foundation of China ; Psychosis project of the Beijing Key Laboratory ; CAS International Cooperation Research Program |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44008 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China 2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 4.Peking Univ, Beijing Huilongguan Hosp, Beijing 100871, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Pinhong,Wang, Dongmei,Xiu, Meihong,et al. Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia[J]. JOURNAL OF CLINICAL MEDICINE,2022,11(21):12. |
APA | Chen, Pinhong.,Wang, Dongmei.,Xiu, Meihong.,Chen, Dachun.,Lackey, Blake.,...&Zhang, Xiangyang.(2022).Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia.JOURNAL OF CLINICAL MEDICINE,11(21),12. |
MLA | Chen, Pinhong,et al."Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia".JOURNAL OF CLINICAL MEDICINE 11.21(2022):12. |
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