Institutional Repository of Key Laboratory of Mental Health, CAS
A comparison of methods to harmonize cortical thickness measurements across scanners and sites | |
Sun, Delin1,2,66; Rakesh, Gopalkumar1,2; Haswell, Courtney C.1,2; Logue, Mark3,4,5,6; Baird, C. Lexi1,2; O'Leary, Erin N.7; Cotton, Andrew S.7; Xie, Hong7; Tamburrino, Marijo7; Chen, Tian7,8; Dennis, Emily L.8,9,10,11; Jahanshad, Neda9; Salminen, Lauren E.9; Thomopoulos, Sophia, I9; Rashid, Faisal9; Ching, Christopher R. K.9; Koch, Saskia B. J.12,13; Frijling, Jessie L.12; Nawijn, Laura12,14; van Zuiden, Mirjam12; Zhu, Xi15,16; Suarez-Jimenez, Benjamin15,16,80; Sierk, Anika17; Walter, Henrik17; Manthey, Antje17; Stevens, Jennifer S.18; Fani, Negar18; van Rooij, Sanne J. H.18; Stein, Murray19; Bomyea, Jessica19; Koerte, Inga K.8,20; Choi, Kyle21; van der Werff, Steven J. A.22,23; Vermeiren, Robert R. J. M.22; Herzog, Julia24; Lebois, Lauren A. M.25,26; Baker, Justin T.27; Olson, Elizabeth A.25,28; Straube, Thomas29; Korgaonkar, Mayuresh S.30; Andrew, Elpiniki31; Zhu, Ye32,33; Li, Gen32,33; Ipser, Jonathan34; Hudson, Anna R.35; Peverill, Matthew36; Sambrook, Kelly37; Gordon, Evan79; Baugh, Lee41,42,43; Forster, Gina41,42,44; Simons, Raluca M.42,45; Simons, Jeffrey S.43,45; Magnotta, Vincent46; Maron-Katz, Adi47; du Plessis, Stefan48; Disner, Seth G.49,50; Davenport, Nicholas49,50; Grupe, Daniel W.51; Nitschke, Jack B.52; DeRoon-Cassini, Terri A.53; Fitzgerald, Jacklynn M.54; Krystal, John H.55,56; Levy, Ifat55,56; Olff, Miranda12,57; Veltman, Dick J.58; Wang, Li32,33; Neria, Yuval15,16; De Bellis, Michael D.59; Jovanovic, Tanja60; Daniels, Judith K.61; Shenton, Martha8,62; van de Wee, Nic J. A.22,23; Schmahl, Christian24; Kaufman, Milissa L.25,63; Rosso, Isabelle M.25,28; Sponheim, Scott R.49,50; Hofmann, David Bernd29; Bryant, Richard A.64; Fercho, Kelene A.41,42,43,65; Stein, Dan J.34; Mueller, Sven C.35; Hosseini, Bobak67; Phan, K. Luan67,68; McLaughlin, Katie A.69; Davidson, Richard J.51,52,70; Larson, Christine L.71; May, Geoffrey38,39,40,72; Nelson, Steven M.38,39,40,72; Abdallah, Chadi G.55,56; Gomaa, Hassaan73; Etkin, Amit47,74; Seedat, Soraya48; Harpaz-Rotem, Ilan55,56; Liberzon, Israel75; van Erp, Theo G. M.76,77; Quide, Yann64,81; Wang, Xin78; Thompson, Paul M.9; Morey, Rajendra A.1,2 | |
第一作者 | Delin Sun |
通讯作者邮箱 | rajendra.morey@duke.edu (r.a. morey) |
摘要 | Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LME INT), (2) LME that models both site-specific random intercepts and age-related random slopes (LME INT+ SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 cases with posttraumatic stress disorder (PTSD) (6.2-81.8 years old) and 2,057 trauma-exposed controls without PTSD (6.3-85.2 years old). We found that, compared to the other data harmonization methods, data processed with ComBat-GAM was more sensitive to the detection of significant case-control differences (X-2 (3) = 63.704, p < 0.001) as well as casecontrol differences in age-related cortical thinning (X-2 (3) = 12.082, p = 0.007). Both ComBat and ComBat-GAM outperformed LME methods in detecting sex differences (X-2 (3) = 9.114, p = 0.028) in regional cortical thickness. ComBat-GAM also led to stronger estimates of age-related declines in cortical thickness (corrected p-values < 0.001), stronger estimates of case-related cortical thickness reduction (corrected p-values < 0.001), weaker estimates of age-related declines in cortical thickness in cases than controls (corrected p-values < 0.001), stronger estimates of cortical thickness reduction in females than males (corrected p-values < 0.001), and stronger estimates of cortical thickness reduction in females relative to males in cases than controls (corrected p-values < 0.001). Our results support the use of ComBat-GAM to minimize confounds and increase statistical power when harmonizing data with non-linear effects, and the use of either ComBat or ComBat-GAM for harmonizing data with linear effects. |
关键词 | Data Harmonization Scanner Effects Site Effects Cortical Thickness ComBat ComBat-GAM Linear Mixed-Effects Model General Additive Model PTSD |
2022-11-01 | |
语种 | 英语 |
DOI | 10.1016/j.neuroimage.2022.119509 |
发表期刊 | NEUROIMAGE |
ISSN | 1053-8119 |
卷号 | 261页码:19 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | DoD[W81XWH-10-1-0925] ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant ; VA CDA[CX001600] ; NHMRC[1073041] ; NHMRC[R01 MH111671] ; VISN6 MIRECC ; German Research Foundation[DA 1222/4-1] ; German Research Foundation[WA 1539/8-2] ; VA RRD[1IK2RX000709] ; VA RRD[1K1RX002325] ; VA RRD[1K2RX002922] ; VA RRD[MH101380] ; VA RRD[I01RX000622] ; NIMH[R01-MH043454] ; NIMH[K01-MH122774] ; NIMH[K01 MH118428-01] ; NIMH[R01MH105535] ; NIMH[1R21MH102634] ; ZonMw, the Netherlands organization for Health Research and Development[40-0081298-10041] ; Academic Medical Center Research Council[110614] ; VA CSRD[1IK2CX001680] ; VISN17 Center of Excellence pilot funding ; German Federal Ministry of Education and Research[BMBF RELEASE 01KR1303A] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[SFB/TRR 58] ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; Department of Veterans Affairs ; NIAAA ; NCATS ; NIH[R01 MH106574] ; NIH[F32MH109274] ; BOF 2-4 year project[01J05415] ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship ; National Institute of Child Health and Human Development[P30-HD003352] ; Veterans Affairs Merit Review Program[10/01/08 09/30/13] ; South African Medical Research Council SHARED ROOTS Flagship Project ; South African Research Chair in PTSD from the Department of Science and Technology ; National Research Foundation ; US Department of Defense[W81XWH08-2-0159] ; CDMRP[W81XWH-08-2-0038] ; South African Medical Research Council ; NARSAD ; Department of Defense[W81XWH-12-2-0012] ; Big Data to Knowledge (BD2K) program[U54 EB020403] ; 'NIMH'[R01-MH043454] ; 'NIMH'[1R21MH102634] ; 'NIMH'[R01 MH63407] ; 'NIMH'[K01 MH118467] ; 'NIMH'[W81XWH-08-2-0159] ; 'NIMH'[K23MH112873] ; 'NIMH'[R01MH113574] ; 'NIMH'[R01-MH103291] ; 'NIMH'[R01 AA12479] ; 'NIMH'[R01 MH61744] ; 'NIMH'[T32-MH018931] ; [5U01AA021681-08] ; [K24MH71434] ; [K24 DA028773] ; [K99NS096116] ; [R01MH117601] ; [R01AG059874] ; [MJFF 14848] ; [MH098212] ; [MH071537] ; [M01RR00039] ; [UL1TR000454] ; [HD071982] ; [HD085850] ; [R21MH112956] ; [R01MH105355] ; [L30 MH114379] ; [RFA-FSP-01-2013/SHARED ROOTS] ; [R56AG058854] ; [R01MH116147] ; [P41 EB015922] ; [1R01MH110483] ; [1R21 MH098198] ; [R01MH105355-01A] |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS关键词 | MULTISITE ; DISORDER ; VOLUME |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000889462400003 |
WOS分区 | Q1 |
资助机构 | DoD ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant ; VA CDA ; NHMRC ; VISN6 MIRECC ; German Research Foundation ; VA RRD ; NIMH ; ZonMw, the Netherlands organization for Health Research and Development ; Academic Medical Center Research Council ; VA CSRD ; VISN17 Center of Excellence pilot funding ; German Federal Ministry of Education and Research ; German Research Society (Deutsche Forschungsgemeinschaft, DFG) ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; Department of Veterans Affairs ; NIAAA ; NCATS ; NIH ; BOF 2-4 year project ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship ; National Institute of Child Health and Human Development ; Veterans Affairs Merit Review Program ; South African Medical Research Council SHARED ROOTS Flagship Project ; South African Research Chair in PTSD from the Department of Science and Technology ; National Research Foundation ; US Department of Defense ; CDMRP ; South African Medical Research Council ; NARSAD ; Department of Defense ; Big Data to Knowledge (BD2K) program ; 'NIMH' |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44076 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Morey, Rajendra A. |
作者单位 | 1.Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA 2.Dept Vet Affairs VA Midatlantic Mental Illness Re, Durham, NC USA 3.VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA 4.Boston Univ, Dept Psychiat, Sch Med, Boston, MA 02118 USA 5.Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA 6.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA 7.Univ Toledo, Dept Psychiat, Toledo, OH USA 8.Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA 9.USC, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Marina Del Rey, CA USA 10.Univ Utah, Dept Neurol, Salt Lake City, UT USA 11.Stanford Neurodev Affect & Psychopathol Lab, Stanford, CA USA 12.Univ Amsterdam, Amsterdam Univ Med Ctr, Acad Med Ctr, Dept Psychiat, Amsterdam, Netherlands 13.Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands 14.Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, VU Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands 15.Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA 16.New York State Psychiat Inst & Hosp, New York, NY 10032 USA 17.Univ Med Ctr Charite, Berlin, Germany 18.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA 19.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA 20.Ludwig Maximilians Univ Munchen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Munich, Germany 21.Univ Calif San Diego, Hlth Serv Res Ctr, La Jolla, CA 92093 USA 22.Leiden Univ Med Ctr, Dept Psychiat, Leiden, Netherlands 23.Leiden Inst Brain & Cognit, Leiden, Netherlands 24.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychosomat Med & Psychotherapy, Heidelberg, Germany 25.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA 26.McLean Hosp, Div Depress & Anxiety Disorders, 115 Mill St, Belmont, MA 02178 USA 27.Harvard Univ, McLean Hosp, Inst Technol Psychiat, Belmont, MA 02178 USA 28.McLean Hosp, Ctr Depress Anxiety & Stress Res, 115 Mill St, Belmont, MA 02178 USA 29.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany 30.Univ Sydney, Brain Dynam Ctr, Westmead Inst Med Res, Westmead, NSW, Australia 31.Univ Sydney, Dept Psychol, Westmead, NSW, Australia 32.Chinese Acad Sci, Chinese Acad Sci Key Lab Mental Hlth, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China 33.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 34.Univ Cape Town, Dept Psychiat & Neurosci Inst, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa 35.Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium 36.Univ Washington, Dept Psychol, Seattle, WA 98195 USA 37.Univ Washington, Dept Radiol, Seattle, WA 98195 USA 38.Vet Integrated Serv Network 17 Ctr Excellence Res, Waco, TX USA 39.Baylor Univ, Dept Psychol & Neurosci, Waco, TX 76798 USA 40.Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Dallas, TX USA 41.Univ South Dakota, Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD USA 42.Univ South Dakota, Ctr Brain & Behav Res, Vermillion, SD USA 43.Sioux Falls VA Hlth Care Syst, Sioux Falls, SD USA 44.Univ Otago, Brain Hlth Res Ctr, Dept Anat, Dunedin, New Zealand 45.Univ South Dakota, Dept Psychol, Vermillion, SD USA 46.Univ Iowa, Dept Radiol Psychiat & Biomed Engn, Iowa City, IA USA 47.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA 48.Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa 49.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 50.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 51.Univ Wisconsin, Ctr Hlth Minds, Madison, WI USA 52.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA 53.Med Coll Wisconsin, Dept Surg, Div Trauma & Acute Care Surg, Milwaukee, WI USA 54.Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA 55.Natl Ctr PTSD, Div Clin Neurosci, West Haven, CT USA 56.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA 57.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands 58.Amsterdam Univ Med Ctr, Dept Psychiat, Locat VUMC, Amsterdam, Netherlands 59.Duke Univ, Dept Psychiat & Behav Sci, Hlth Childhood Brain Dev Dev Traumatol Res Progra, Durham, NC USA 60.Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA 61.Univ Groningen, Dept Clin Psychol, Groningen, Netherlands 62.VA Boston Healthcare Syst, Brockton Div, Brockton, MA USA 63.McLean Hosp, Div Womens Mental Hlth, 115 Mill St, Belmont, MA 02178 USA 64.Univ New South Wales, Sch Psychol, Sydney, NSW, Australia 65.US Fed Aviat Adm, Civil Aerosp Med Inst, Oklahoma City, OK USA 66.Educ Univ Hong Kong, Dept Psychol, Hong Kong, Peoples R China 67.Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA 68.Jesse Brown VA Chicago Hlth Care Syst, Mental Hlth Serv Line, Chicago, IL USA 69.Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA 70.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA 71.Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA 72.Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Bryan, TX USA 73.Penn State Univ, Dept Psychiat & Behav Hlth, Hershey, PA USA 74.VA Palo Alto Hlth Care Syst, Palo Alto, CA USA 75.Texas A&M Univ, Dept Psychiat & Behav Sci, College Stn, TX USA 76.Univ Calif Irvine, Dept Psychiat & Human Behav, Clin Translat Neurosci Lab, Irvine, CA 92717 USA 77.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA USA 78.Univ Toledo, Dept Math & Stat, Toledo, OH USA 79.Washington Univ, Dept Radiol, St Louis, MO 63110 USA 80.Univ Rochester, Med Ctr, Del Monte Inst Neurosci, Rochester, NY 14642 USA 81.Neurosci Res Australia, Randwick, NSW, Australia |
推荐引用方式 GB/T 7714 | Sun, Delin,Rakesh, Gopalkumar,Haswell, Courtney C.,et al. A comparison of methods to harmonize cortical thickness measurements across scanners and sites[J]. NEUROIMAGE,2022,261:19. |
APA | Sun, Delin.,Rakesh, Gopalkumar.,Haswell, Courtney C..,Logue, Mark.,Baird, C. Lexi.,...&Morey, Rajendra A..(2022).A comparison of methods to harmonize cortical thickness measurements across scanners and sites.NEUROIMAGE,261,19. |
MLA | Sun, Delin,et al."A comparison of methods to harmonize cortical thickness measurements across scanners and sites".NEUROIMAGE 261(2022):19. |
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