New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination | |
Chen, He1; Wang, Menghan2; Xia, Lin3,4; Dong, Jiong3,5; Xu, Guangwei1; Wang, Ziyi1; Feng, Lixia3,4; Zhou, Yifeng1,5 | |
通讯作者 | Feng, Lixia(lixiafeng@163.com) ; Zhou, Yifeng(zhouy@ustc.edu.cn) |
摘要 | Diabetes can damage both the peripheral sensory organs, causing retinopathy, and the central visual system, leading to contrast sensitivity and impaired color vision in patients without retinopathy. Orientation discrimination is important for shape recognition by the visual system. Our psychophysical findings in this study show diminished orientation discrimination in patients with diabetes without retinopathy. To reveal the underlying mechanism, we established a diabetic mouse model and recorded in vivo electrophysiological data in the dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (V1). Reduced orientation selectivity was observed in both individual and populations of neurons in V1 and dLGN, which increased in severity with disease duration. This diabetes-associated neuronal dysfunction appeared earlier in the V1 than dLGN. Additionally, neuronal activity and signal-to-noise ratio are reduced in V1 neurons of diabetic mice, leading to a decreased capacity for information processing by V1 neurons. Notably, the V1 in diabetic mice exhibits reduced excitatory neuronal activity and lower levels of phosphorylated mammalian target of rapamycin (mTOR). Our findings show that altered responses of both populations of and single V1 neurons may impair fine vision, thus expanding our understanding of the underlying causes of diabetes-related impairment of the central nervous system. |
2022-08-01 | |
语种 | 英语 |
DOI | 10.2337/db21-0715 |
发表期刊 | DIABETES |
ISSN | 0012-1797 |
卷号 | 71期号:8页码:1772-1784 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[NSFC 32070990] ; Anhui Province's Key Research and Development Plan[9021033204] |
出版者 | AMER DIABETES ASSOC |
WOS关键词 | ORIENTATION SELECTIVITY ; RECEPTIVE FIELDS ; NEURONS ; CORTEX ; BRAIN ; AFFERENTS ; GABA |
WOS研究方向 | Endocrinology & Metabolism |
WOS类目 | Endocrinology & Metabolism |
WOS记录号 | WOS:000905184100019 |
资助机构 | National Natural Science Foundation of China ; Anhui Province's Key Research and Development Plan |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44416 |
专题 | 认知与发展心理学研究室 |
通讯作者 | Feng, Lixia; Zhou, Yifeng |
作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Sch Life Sci, Hefei, Peoples R China 2.Univ Sci & Technol China, Sch Informat Sci & Technol, Hefei, Peoples R China 3.Anhui Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Hefei, Peoples R China 4.Natl Clin Res Ctr Ocular Dis, Anhui Branch, Hefei, Peoples R China 5.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Hefei, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, He,Wang, Menghan,Xia, Lin,et al. New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination[J]. DIABETES,2022,71(8):1772-1784. |
APA | Chen, He.,Wang, Menghan.,Xia, Lin.,Dong, Jiong.,Xu, Guangwei.,...&Zhou, Yifeng.(2022).New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination.DIABETES,71(8),1772-1784. |
MLA | Chen, He,et al."New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination".DIABETES 71.8(2022):1772-1784. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论