New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination

doi:10.2337/db21-0715

PSYCH OpenIR > 认知与发展心理学研究室

	New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination
	Chen, He 1; Wang, Menghan 2; Xia, Lin 3,4; Dong, Jiong 3,5; Xu, Guangwei 1; Wang, Ziyi 1; Feng, Lixia 3,4; Zhou, Yifeng 1,5
通讯作者	Feng, Lixia(lixiafeng@163.com) ; Zhou, Yifeng(zhouy@ustc.edu.cn)
摘要	Diabetes can damage both the peripheral sensory organs, causing retinopathy, and the central visual system, leading to contrast sensitivity and impaired color vision in patients without retinopathy. Orientation discrimination is important for shape recognition by the visual system. Our psychophysical findings in this study show diminished orientation discrimination in patients with diabetes without retinopathy. To reveal the underlying mechanism, we established a diabetic mouse model and recorded in vivo electrophysiological data in the dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (V1). Reduced orientation selectivity was observed in both individual and populations of neurons in V1 and dLGN, which increased in severity with disease duration. This diabetes-associated neuronal dysfunction appeared earlier in the V1 than dLGN. Additionally, neuronal activity and signal-to-noise ratio are reduced in V1 neurons of diabetic mice, leading to a decreased capacity for information processing by V1 neurons. Notably, the V1 in diabetic mice exhibits reduced excitatory neuronal activity and lower levels of phosphorylated mammalian target of rapamycin (mTOR). Our findings show that altered responses of both populations of and single V1 neurons may impair fine vision, thus expanding our understanding of the underlying causes of diabetes-related impairment of the central nervous system.
	2022-08-01
语种	英语
DOI	10.2337/db21-0715
发表期刊	DIABETES
ISSN	0012-1797
卷号	71 期号:8 页码:1772-1784
收录类别	SCI
资助项目	National Natural Science Foundation of China[NSFC 32070990] ; Anhui Province's Key Research and Development Plan[9021033204]
出版者	AMER DIABETES ASSOC
WOS关键词	ORIENTATION SELECTIVITY ; RECEPTIVE FIELDS ; NEURONS ; CORTEX ; BRAIN ; AFFERENTS ; GABA
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000905184100019
资助机构	National Natural Science Foundation of China ; Anhui Province's Key Research and Development Plan
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/44416
专题	认知与发展心理学研究室
通讯作者	Feng, Lixia; Zhou, Yifeng
作者单位	1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Sch Life Sci, Hefei, Peoples R China 2.Univ Sci & Technol China, Sch Informat Sci & Technol, Hefei, Peoples R China 3.Anhui Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Hefei, Peoples R China 4.Natl Clin Res Ctr Ocular Dis, Anhui Branch, Hefei, Peoples R China 5.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Chen, He,Wang, Menghan,Xia, Lin,et al. New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination[J]. DIABETES,2022,71(8):1772-1784.
APA	Chen, He.,Wang, Menghan.,Xia, Lin.,Dong, Jiong.,Xu, Guangwei.,...&Zhou, Yifeng.(2022).New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination.DIABETES,71(8),1772-1784.
MLA	Chen, He,et al."New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination".DIABETES 71.8(2022):1772-1784.