Institutional Repository of Key Laboratory of Mental Health, CAS
P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia | |
Lang, XiaoE1,5; Wang, Dongmei2,3; Zhou, Huixia2,3; Wang, Li; Kosten, Thomas R.4; Zhang, Xiang-Yang2,3,6 | |
第一作者 | XiaoE Lang |
通讯作者邮箱 | langxiaoe@yeah.net (x. lang) ; zhangxy@psych.ac.cn (x.-y. zhang) |
心理所单位排序 | 2 |
摘要 | Background: Sensory gating deficits and gray matter volume (GMV) abnormalities have been found to be asso-ciated with the pathogenesis and psychopathology of patients with schizophrenia (SCZ). However, no studies have investigated their interrelationship in first-episode treatment-naive (FETN) SCZ patients.Methods: We recruited 52 FETN SCZ patients and 57 healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to measure the psychopathology of the patients. We collected magnetic resonance imaging and P50 inhibition data from all participants. Results: Compared to healthy controls, patients had shorter S1 and S2 latencies but larger S2 amplitudes and P50 ratio (Bonferroni adjusted all p < 0.01). In patients, S2 latency was independently associated with PANSS total score, negative symptoms and general psychopathology (t = 2.26-2.58, both P < 0.05), whereas S1 (t = 2.44, P < 0.05) and S2 latencies (t = 2.13, P < 0.05) were associated with PANSS cognitive factor. Moreover, GMV in the left inferior temporal gyrus, left lingual gyrus and right superior occipital gyrus, and bilateral dorsolateral su-perior frontal gyrus were each associated with the P50 components (all p < 0.05). In addition, GMV associated with S2 latency was negatively correlated with PANSS general psychopathology (t =-2.46, p < 0.05) and total score (t =-2.34, p < 0.05). Conclusions: Our findings indicate that FETN SCZ patients exhibit deficits in P50 inhibition and GMV of brain regions associated with these deficits may be associated with their psychopathological symptoms, suggesting that brain structures associated with P50 components may be important biomarkers of SCZ psychopathology. Future studies could use a prospective longitudinal design to investigate the potential causal relationship of brain structures associated with P50 components in the psychopathological symptoms of SCZ patients. |
关键词 | Schizophrenia Gray matter volume Sensory gating P50 Symptom |
2023-02-01 | |
DOI | 10.1016/j.ajp.2022.103421 |
发表期刊 | ASIAN JOURNAL OF PSYCHIATRY |
ISSN | 1876-2018 |
卷号 | 80页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Regional Science and Technology Development (Basic Research) Project[YDZJSX2022A064] ; Special Grant 136 of First Hospital of Shangxi Medical University Project[Y2022136006] ; Key Research and Development (R&D) Projects of Shanxi Province of China[201803D31098] ; Grant for clinical research by Wu Jieping Medical Foundation[320.6750.18336] |
出版者 | ELSEVIER |
WOS关键词 | ACOUSTIC STARTLE MAGNITUDE ; NEGATIVE SYNDROME SCALE ; SUPPRESSION DEFICITS ; PREPULSE INHIBITION ; TEMPORAL GYRUS ; LATENCY ; ABNORMALITIES ; NEUROCOGNITION ; HERITABILITY ; ASSOCIATION |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000911422100001 |
WOS分区 | Q1 |
资助机构 | Regional Science and Technology Development (Basic Research) Project ; Special Grant 136 of First Hospital of Shangxi Medical University Project ; Key Research and Development (R&D) Projects of Shanxi Province of China ; Grant for clinical research by Wu Jieping Medical Foundation |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44555 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Lang, XiaoE; Zhang, Xiang-Yang |
作者单位 | 1.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Baylor Coll Med, Dept Psychiat, Houston, TX USA 5.85 Jiefang Southern Rd, Taiyuan 030001, Shanxi, Peoples R China 6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室; 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Lang, XiaoE,Wang, Dongmei,Zhou, Huixia,et al. P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2023,80:8. |
APA | Lang, XiaoE,Wang, Dongmei,Zhou, Huixia,Wang, Li,Kosten, Thomas R.,&Zhang, Xiang-Yang.(2023).P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,80,8. |
MLA | Lang, XiaoE,et al."P50 inhibition defects, psychopathology and gray matter volume in patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 80(2023):8. |
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