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Association between thyroid hormones and comorbid psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder | |
Peng, Pu1,2; Wang, Qianjin1,2; Ren, Honghong3; Zhou, Yanan1,2,4; Hao, Yuzhu1,2; Chen, Shubao1,2; Wu, Qiuxia1,2; Li, Manyun1,2; Wang, Yunfei1,2; Yang, Qian1,2; Wang, Xin1,2; Liu, Yueheng1,2; Ma, Yuejiao1,2; Li, He1,2; Liu, Tieqiao1,2; Zhang, Xiangyang5 | |
第一作者 | Pu Peng |
通讯作者邮箱 | liutieqiao123@csu.edu.cn (t. liu) ; zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 5 |
摘要 | Thyroid dysfunction is common in major depressive disorder (MDD) patients; however, its relationship with psychotic depression (PD) remains unclear. We aimed to assess thyroid hormones in 1718 first episode drug naive (FEND) MDD patients and to determine their association with PD. The positive subscale of the Positive and Negative Symptom Scale (PANSS-P), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD) were used to detect clinical symptoms. The serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), and thyroid peroxidases anti-body (TPOAb) were assessed. The logistic regression model was conducted to determine risk factors for PD, and the Area Under the Curve (AUC) was used to test the performance of this model. 171 (10%) patients were identified as having PD. Serum levels of TSH, TgAb, and TPOAb displayed small-to-moderate associations with PANSS-P. HAMA score, HAMD score, and TSH levels were independently associated with PD. The regression model had excellent power to distinguish PD patients from non-PD patients with an AUC value of 0.93. Our study suggests TSH levels and severity of depression and anxiety symptoms were independent risk factors for PD. Regular thyroid function tests may help early detect PD. |
关键词 | Psychotic depression Anxiety First -episode and drug -na?ve Thyroid -stimulating hormone |
2023-02-01 | |
语种 | 英语 |
DOI | 10.1016/j.psychres.2023.115052 |
发表期刊 | PSYCHIATRY RESEARCH |
ISSN | 0165-1781 |
卷号 | 320页码:6 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | CAS Pioneer Hundred Talents Pro-gram ; National Natural Science Foundation of China[81371477] |
出版者 | ELSEVIER IRELAND LTD |
WOS关键词 | CLINICAL CHARACTERISTICS ; SUICIDE ATTEMPTS ; DYSFUNCTION ; PATTERNS |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000920412000001 |
WOS分区 | Q1 |
资助机构 | CAS Pioneer Hundred Talents Pro-gram ; National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44588 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Liu, Tieqiao; Zhang, Xiangyang |
作者单位 | 1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China 2.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China 3.Shandong First Med Univ, Shandong Prov Hosp, Tai An, Shandong, Peoples R China 4.Hunan Brain Hosp, Hunan Peoples Hosp 2, Dept Psychiat, Changsha, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Peng, Pu,Wang, Qianjin,Ren, Honghong,et al. Association between thyroid hormones and comorbid psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder[J]. PSYCHIATRY RESEARCH,2023,320:6. |
APA | Peng, Pu.,Wang, Qianjin.,Ren, Honghong.,Zhou, Yanan.,Hao, Yuzhu.,...&Zhang, Xiangyang.(2023).Association between thyroid hormones and comorbid psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder.PSYCHIATRY RESEARCH,320,6. |
MLA | Peng, Pu,et al."Association between thyroid hormones and comorbid psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder".PSYCHIATRY RESEARCH 320(2023):6. |
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