P50 sensory gating, cognitive deficits and depressive symptoms in first-episode antipsychotics-naive schizophrenia

doi:10.1016/j.jad.2022.12.143

PSYCH OpenIR

	P50 sensory gating, cognitive deficits and depressive symptoms in first-episode antipsychotics-naive schizophrenia
	Li, Shen 1; Yu, Bin 2,3; Wang, Dongmei 4,5; Xia, Luyao 4,5; Wang, Li 4,5; Chen, Dachun 6; Xiu, Meihong 6; Zhang, Xiang Yang 4,5,7
通讯作者	Zhang, Xiang Yang(zhangxy@psych.ac.cn)
摘要	Objective: Sensory gating P50 (SG-P50) may be involved in the pathophysiological mechanisms of impaired cognition in schizophrenia (SCZ). Comorbid depressive symptoms are common in SCZ patients and are also found to be associated with their cognitive impairment. However, it is unclear whether SG-P50 is abnormal in first episode antipsychotics naive (FEAN) SCZ patients with depressive symptoms. Our aimed to investigate the re-lationships between SG-P50, depressive symptoms and neurocognition in FEAN-SCZ patients. Methods: We recruited 103 FEAN-SCZ patients (depression: n = 63; non-depression: n = 40) and 55 healthy controls. SG-P50 was measured using the standard auditory dual-click (S1&S2) paradigm. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Depression Rating Scale-17 (HDRS-17). Cognitive performance was evaluated using the MATRICS Consensus Cognitive Battery (MCCB). Results: Compared with non-depressive patients, depressive patients had a significantly larger S2 amplitude (p = 0.005) and a higher S2/S1 ratio at trend level (p = 0.075) after corrected. There were significant differences in the scores of CPT-IP and Mazes (NAB) between depressive and non-depressive FEAN-SCZ patients (both p values < 0.05). For all patients, the SG-P50 S2/S1 ratio was significantly correlated with HDRS-17 score (r = 0.23, p = 0.020) and MCCB-Symbol coding (r =-0.16, p = 0.043). For depressive FEAN-SCZ patients, S2 amplitude was an independent predictor of the MCCB-Mazes (NAB) (beta =-0.31, t =-2.52, p = 0.015). Conclusions: SG-P50 deficit may be an informational biomarker for depressive symptoms and neurocognitive impairments in FEAN-SCZ patients.
关键词	Schizophrenia Depressive symptoms P50 sensory gating Cognition First episode
	2023-03-01
语种	英语
DOI	10.1016/j.jad.2022.12.143
发表期刊	JOURNAL OF AFFECTIVE DISORDERS
ISSN	0165-0327
卷号	324 页码:153-161
收录类别	SCI
资助项目	National Natural Science Foundation of China[81801323] ; Tianjin Key Medical Discipline (Specialty) Con-struction Project[TJYXZDXK-033A]
出版者	ELSEVIER
WOS关键词	PREPULSE INHIBITION ; SUPPRESSION DEFICITS ; FUNCTIONAL-CAPACITY ; NEURAL GENERATORS ; MAJOR DEPRESSION ; DRUG-NAIVE ; ATTENTION ; DISORDER ; FEATURES ; ASSOCIATIONS
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:000918133900001
资助机构	National Natural Science Foundation of China ; Tianjin Key Medical Discipline (Specialty) Con-struction Project
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/44601
通讯作者	Zhang, Xiang Yang
作者单位	1.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, Tianjin, Peoples R China 2.Tianjin Univ, Inst Appl Psychol, Tianjin, Peoples R China 3.Tianjin Univ, Acad Med Engn & Translat Med, Tianjin, Peoples R China 4.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li, Shen,Yu, Bin,Wang, Dongmei,et al. P50 sensory gating, cognitive deficits and depressive symptoms in first-episode antipsychotics-naive schizophrenia[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,324:153-161.
APA	Li, Shen.,Yu, Bin.,Wang, Dongmei.,Xia, Luyao.,Wang, Li.,...&Zhang, Xiang Yang.(2023).P50 sensory gating, cognitive deficits and depressive symptoms in first-episode antipsychotics-naive schizophrenia.JOURNAL OF AFFECTIVE DISORDERS,324,153-161.
MLA	Li, Shen,et al."P50 sensory gating, cognitive deficits and depressive symptoms in first-episode antipsychotics-naive schizophrenia".JOURNAL OF AFFECTIVE DISORDERS 324(2023):153-161.