Institutional Repository of Key Laboratory of Mental Health, CAS
Selective and replicable neuroimaging-based indicators of pain discriminability | |
Zhang, Li-Bo1,2; Lu, Xue-Jing1,2; Huang, Gan3,4; Zhang, Hui -Juan1,2; Tu, Yi-Heng1,2; Kong, Ya-Zhuo2,5; Hu, Li1,2 | |
第一作者 | Li-Bo Zhang |
通讯作者邮箱 | huli@psych.ac.cn (li hu ) |
摘要 | Neural indicators of pain discriminability have far-reaching theoretical and clinical implications but have been largely overlooked previously. Here, to directly identify the neural basis of pain discriminability, we apply signal detection theory to three EEG (Datasets 1-3, total N = 366) and two fMRI (Datasets 4-5, total N = 399) datasets where participants receive transient stimuli of four sensory modalities (pain, touch, audition, and vision) and two intensities (high and low) and report perceptual ratings. Datasets 1 and 4 are used for exploration and others for validation. We find that most pain-evoked EEG and fMRI brain responses robustly encode pain discriminability, which is well replicated in validation datasets. The neural indicators are also pain selective since they cannot track tactile, auditory, or visual discriminability, even though perceptual ratings and sensory discriminability are well matched between modalities. Overall, we provide compelling evidence that pain-evoked brain responses can serve as replicable and selective neural indicators of pain discriminability. |
2022-12-20 | |
DOI | 10.1016/j.xcrm.2022.100846 |
发表期刊 | CELL REPORTS MEDICINE |
ISSN | 2666-3791 |
卷号 | 3期号:12页码:23 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[32071061] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[32171077] ; Beijing Natural Science Foundation[32171077] ; Ministry of Science and Technology of the People's Republic of China[2022ZD0206400] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4015] |
出版者 | ELSEVIER |
WOS关键词 | LASER-EVOKED POTENTIALS ; SENSORY-DECISION-THEORY ; SIGNAL-DETECTION ; INTENSITY DISCRIMINATION ; SOMATOSENSORY CORTEX ; HUMAN BRAIN ; THRESHOLD MEASURES ; RADIANT-HEAT ; PERCEPTION ; RESPONSES |
WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
WOS类目 | Cell Biology ; Medicine, Research & Experimental |
WOS记录号 | WOS:000912406500001 |
WOS分区 | Q1 |
资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Ministry of Science and Technology of the People's Republic of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44688 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Hu, Li |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Shenzhen 518060, Peoples R China 4.Shenzhen Univ, Guangdong Prov Key Lab Biomed Measurements & Ultra, Shenzhen 518060, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Li-Bo,Lu, Xue-Jing,Huang, Gan,et al. Selective and replicable neuroimaging-based indicators of pain discriminability[J]. CELL REPORTS MEDICINE,2022,3(12):23. |
APA | Zhang, Li-Bo.,Lu, Xue-Jing.,Huang, Gan.,Zhang, Hui -Juan.,Tu, Yi-Heng.,...&Hu, Li.(2022).Selective and replicable neuroimaging-based indicators of pain discriminability.CELL REPORTS MEDICINE,3(12),23. |
MLA | Zhang, Li-Bo,et al."Selective and replicable neuroimaging-based indicators of pain discriminability".CELL REPORTS MEDICINE 3.12(2022):23. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Selective and replic(7258KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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