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Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients | |
Lui, Simon S. Y.1; Wang, Ling-ling2,3; Lau, Wilson Y. S.4; Shing, Eunice1; Yeung, Hera K. H.4; Tsang, Kirby C. M.4; Zhan, Emma N.1; Cheung, Ezmond S. L.1; Ho, Karen K. Y.4; Hung, Karen S. Y.1; Cheung, Eric F. C.4; Chan, Raymond C. K.2,3,5 | |
第一作者 | Simon S.Y. Lui |
通讯作者邮箱 | lsy570@hku.hk (s.s.y. lui) ; rckchan@psych.ac.cn (r.c.k. chan) |
心理所单位排序 | 2 |
摘要 | Background: Emotion-behaviour decoupling refers to the failure to translate emotion into motivated behaviour, and is a putative marker for schizophrenia. The heterogeneity of experiential pleasure and emotion expressivity deficits has been reported in schizophrenia patients. These three constructs are believed to contribute to negative symptoms, but very few studies have examined their predictive ability for clinical and functional outcome of schizophrenia. This study aimed to clarify whether these three constructs influence clinical and functional outcome of schizophrenia.Method: At baseline, 127 first-episode schizophrenia patients completed a behavioural paradigm for emotion -behaviour decoupling, and self-report scales for experiential pleasure and emotion expressivity deficits. Cluster-analysis was applied to characterize schizophrenia subgroups based on these three constructs. At end-point (mean follow-up = 5.37 years, SD = 1.03 years), 85 schizophrenia patients were reassessed using the Clinical Assessment Interview for Negative Symptoms (CAINS) and a clinician-rated social functioning scale.Results: Cluster 1 (n = 74) did not show emotion-behaviour decoupling, and had intact experiential pleasure and emotion expressivity. Cluster 2 (n = 29) showed emotion-behaviour decoupling and experiential pleasure def-icits. Cluster 3 (n = 24) showed emotion expressivity deficits. At endpoint, the three clusters differed significantly in CAINS MAP factor (p = 0.016) and social functioning (p = 0.019), but not CAINS EXP factor. Specifically, Cluster 2 (n = 18) showed more severe negative symptoms of CAINS MAP factor (p = 0.046) and poorer social functioning (p = 0.022) than Cluster 1 (n = 49). Cluster 3 (n = 18) did not differ from Cluster 1 and Cluster 2 in negative symptoms and social functioning.Discussion: Emotion-behaviour decoupling and experiential pleasure deficits predicted clinical and functional outcome of schizophrenia. |
关键词 | Negative symptoms Emotion -behaviour decoupling Experiential pleasure Functional outcome Longitudinal |
2023-03-01 | |
语种 | 英语 |
DOI | 10.1016/j.ajp.2023.103467 |
发表期刊 | ASIAN JOURNAL OF PSYCHIATRY |
ISSN | 1876-2018 |
卷号 | 81页码:7 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | General Research Fund of Research Grant Council[17120622] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3415CX] ; Phillip K.H. Wong Foundation |
出版者 | ELSEVIER |
WOS关键词 | SCALE ; ANHEDONIA ; RELIABILITY ; MOTIVATION ; IV |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000924586500001 |
WOS分区 | Q1 |
资助机构 | General Research Fund of Research Grant Council ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Phillip K.H. Wong Foundation |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44722 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Lui, Simon S. Y.; Chan, Raymond C. K. |
作者单位 | 1.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Castle Peak Hosp, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 认知与发展心理学研究室; 中国科学院心理研究所 |
推荐引用方式 GB/T 7714 | Lui, Simon S. Y.,Wang, Ling-ling,Lau, Wilson Y. S.,et al. Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients[J]. ASIAN JOURNAL OF PSYCHIATRY,2023,81:7. |
APA | Lui, Simon S. Y..,Wang, Ling-ling.,Lau, Wilson Y. S..,Shing, Eunice.,Yeung, Hera K. H..,...&Chan, Raymond C. K..(2023).Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients.ASIAN JOURNAL OF PSYCHIATRY,81,7. |
MLA | Lui, Simon S. Y.,et al."Emotion-behaviour decoupling and experiential pleasure deficits predict negative symptoms and functional outcome in first-episode schizophrenia patients".ASIAN JOURNAL OF PSYCHIATRY 81(2023):7. |
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