The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial

	The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial
	Wei, Kai 1; Bi, Yanzhi2,3 ; Xu, Huihong 1; Shen, Ling 1; Liu, Yantao 1; Chen, Qianbo 1; Miao, Xuerong 1; Wu, Cheng 4; Hu, Li2,3 ; Lu, Zhi-jie 1
通讯作者	Lu, Zhi-jie(lzjwxyz@163.com)
摘要	Background: Smoking behavior alters the analgesic threshold, which challenges postoperative pain management for patients who smoke.Objectives: We aimed to assess the analgesic efficacy of tramadol versus sufentanil in relieving postoperative pain for patients who do and do not smoke who underwent a partial hepatectomy.Study Design: Double-blinded randomized controlled trial.Setting: Eastern Hepatobiliary Surgery Hospital, Shanghai, China.Methods: All patients in this study were men. A total of 66 patients who smoke were randomly assigned to receive tramadol or sufentanil (n = 33 each). In addition, a total of 66 patients who do not smoke were randomly assigned to receive tramadol or sufentanil (n = 33 each). The primary outcome was the consumption of additional analgesics within the first 48 hours to control postoperative pain. Secondary outcomes included the postoperative pain level, the frequency of postoperative nausea and vomiting, the sedation score, and the frequency of fever within 48 hours postsurgery.Results: A significant interaction between "analgesic strategy " and "smoking history " was detected on the consumption of additional analgesics. In those who smoke, the requests for additional doses of analgesics were significantly less in those receiving tramadol than those receiving sufentanil; such a difference was not observed in those who do not smoke. The postoperative pain level was not significantly different between the tramadol group and the sufentanil group within patients who smoke within 48 hours postsurgery. The incidence of treatment-related adverse events was not significantly different between the tramadol group and the sufentanil group within both those who do and do not smoke.Limitations: Only men patients were included. Also, the superior analgesic effect and the incidence of adverse events of tramadol in patients who smoke were only assessed within the first 48 hours postsurgery.Conclusions: Our data suggest that tramadol has a better analgesic effect than sufentanil in relieving postoperative pain in patients who smoke.
关键词	Men patients who smoke tramadol sufentanil postoperative pain management analgesic efficacy RCT analgesic consumption partial hepatectomy
	2022-12-01
语种	英语
发表期刊	PAIN PHYSICIAN
ISSN	1533-3159
卷号	25 期号:9 页码:E1367-E1377
收录类别	SCI
资助项目	Science and Technology Commission of Shanghai Municipality[17411960400] ; Shanghai Shen Kang Hospital Development Center[SHDC12018X19] ; National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[32071061] ; National Natural Science Foundation of China[31822025]
出版者	AM SOC INTERVENTIONAL PAIN PHYSICIANS
WOS关键词	TOBACCO SMOKING ; NICOTINE ; WITHDRAWAL ; REQUIREMENTS ; REWARD
WOS研究方向	Anesthesiology ; Neurosciences & Neurology
WOS类目	Anesthesiology ; Clinical Neurology
WOS记录号	WOS:000918060600004
资助机构	Science and Technology Commission of Shanghai Municipality ; Shanghai Shen Kang Hospital Development Center ; National Natural Science Foundation of China
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/44731
专题	中国科学院心理健康重点实验室
通讯作者	Lu, Zhi-jie
作者单位	1.Shanghai Eastern Hepatobiliary Surg Hosp, Dept Anaesthesiol, Shanghai 200438, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Naval Med Univ, Dept Hlth Stat, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wei, Kai,Bi, Yanzhi,Xu, Huihong,et al. The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial[J]. PAIN PHYSICIAN,2022,25(9):E1367-E1377.
APA	Wei, Kai.,Bi, Yanzhi.,Xu, Huihong.,Shen, Ling.,Liu, Yantao.,...&Lu, Zhi-jie.(2022).The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial.PAIN PHYSICIAN,25(9),E1367-E1377.
MLA	Wei, Kai,et al."The Effect of Tramadol Versus Sufentanil on Controlling Postoperative Pain for Men Who Smoke and Do Not Smoke: A Randomized Clinical Trial".PAIN PHYSICIAN 25.9(2022):E1367-E1377.