Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults | |
Mengge Liu1; Tong Han2; Yue Wu3; Jingliang Cheng4; Longjiang Zhang5; Bing Zhang6; Xi-Nian Zuo7,8; Wenzhen Zhu9; Shijun Qiu10; Zuojun Geng11; Xiaochu Zhang12; Guangbin Cui13; Quan Zhang14; Yongqiang Yu15; Hui Zhang16; Bo Gao17,18; Xiaojun Xu19; Zhenwei Yao3; Wen Qin1; Meng Liang20; Feng Liu1; Lining Guo1; Qiang Xu1; Jilian Fu1; Jiayuan Xu1; Jie Tang1; Nana Liu1; Kaizhong Xue21; Peng Zhang21; Dapeng Shi22; Caihong Wang4; Jia-Hong Gao23; Su Lui24; Zhihan Yan25; Feng Chen26; Jiance Li27; Jing Zhang28,29; Wen Shen30; Yanwei Miao31; Junfang Xian32; Le Yu33; Kai Xu34; Meiyun Wang22; Zhaoxiang Ye21; Wei-Hua Liao35,36,37,38; Dawei Wang38; Chunshui Yu38 | |
第一作者 | Mengge Liu |
通讯作者邮箱 | ouwenliao@163.com (w.-h. liao) ; daweiwangtj@126.com (d. wang) ; chunshuiyu@tmu.edu.cn (c. yu) |
摘要 | BACKGROUND: Urbanicity refers to the conditions that are particular to urban areas and is a growing environmental challenge that may affect hippocampus and neurocognition. This study aimed to investigate the effects of the average pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities as well as the sensitive age windows of the urbanicity effects. PARTICIPANTS AND METHODS: We included 5,390 CHIMGEN participants (3,538 females; age: 23.69±2.26years, range: 18-30years). Pre-adulthood urbanicity of each participant was defined as the average value of annual night-time light (NL) or built-up% from age 0-18, which were extracted from remote-sensing satellite data based on annual residential coordinates of the participants. The hippocampal subfield volumes were calculated based on structural MRI and eight neurocognitive measures were assessed. The linear regression was applied to investigate the associations of pre-adulthood NL with hippocampal subfield volumes and neurocognitive abilities, mediation models were used to find the underlying pathways among urbanicity, hippocampus and neurocognition, and distributed lag models were used to identify sensitive age windows of urbanicity effect. RESULTS: Higher pre-adulthood NL was associated with greater volumes in the left (beta=0.100, 95%CI: [0.075, 0.125]) and right (0.078, [0.052, 0.103]) fimbria and left subiculum body (0.045, [0.020, 0.070]) and better neurocognitive abilities in information processing speed (-0.212, [-0.240, -0.183]), working memory (0.085, [0.057, 0.114]), episodic memory (0.107, [0.080, 0.135]), and immediate (0.094, [0.065, 0.123]) and delayed (0.087, [0.058, 0.116]) visuospatial recall, and hippocampal subfield volumes and visuospatial memory showed bilateral mediations for the urbanicity effects. Urbanicity effects were greatest on the fimbria in preschool and adolescence, on visuospatial memory and information processing from childhood to adolescence and on working memory after 14years. CONCLUSION: These findings improve our understanding of the impact of urbanicity on hippocampus and neurocognitive abilities and will benefit for designing more targeted intervention for neurocognitive improvement. |
关键词 | Hippocampal subfields Urban Neurocognition Remote sensing Neuroimaging |
2023 | |
DOI | 10.1016/j.envint.2023.107905 |
发表期刊 | Environment International |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
Q分类 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44827 |
专题 | 中国科学院心理研究所 |
作者单位 | 1.The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults 2.Department of Radiology, Tianjin Huanhu Hospital, 300350 Tianjin, China 3.Department of Radiology, Huashan Hospital, Fudan University, 200040 Shanghai, China 4.Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China 5.Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 210002 Nanjing, China 6.Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, 210008 Nanjing, China 7.IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875 Beijing, China 8.Institute of Psychology, Chinese Academy of Sciences, 100101 Beijing, China 9.Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China 10.Department of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 510405 Guangzhou, China 11.Department of Medical Imaging, The Second Hospital of Hebei Medical University, 050000 Shijiazhuang, China 12.Division of Life Science and Medicine, University of Science & Technology of China, 230027 Hefei, China 13.Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, 710038 Xi’an, China 14.Department of Radiology, Characteristic Medical Center of Chinese People’s Armed Police Force, 300162 Tianjin, China 15.Department of Radiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, China 16.Department of Radiology, The First Hospital of Shanxi Medical University, 030001 Taiyuan, China 17.Department of Radiology, The Affiliated Hospital of Guizhou Medical University, 550004 Guiyang, China 18.Department of Radiology, Yantai Yuhuangding Hospital, 264000 Yantai, China 19.Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, 310009 Hangzhou, China 20.School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, 300203 Tianjin, China 21.Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, 300060 Tianjin, China 22.Department of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, 450003 Zhengzhou, China 23.Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, 100871 Beijing, China 24.Department of Radiology, the Center for Medical Imaging, West China Hospital of Sichuan University, 610041 Chengdu, China 25.Department of Radiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 325027 Wenzhou, China 26.Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), 570311 Haikou, China 27.Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, China 28.Department of Magnetic Resonance, Lanzhou University Second Hospital, 730030 Lanzhou, China 29.Gansu Province Clinical Research Center for Functional and Molecular Imaging, 730030 Lanzhou, China 30.Department of Radiology, Tianjin First Center Hospital, 300192 Tianjin, China 31.Department of Radiology, The First Affiliated Hospital of Dalian Medical University, 116011 Dalian, China 32.Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 100730 Beijing, China 33.Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, China 34.Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, 221006 Xuzhou, China 35.Department of Radiology, Xiangya Hospital, Central South University, 410008 Changsha, China 36.Molecular Imaging Research Center of Central South University, 410008 Changsha, China 37.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008 Changsha, China 38.Department of Radiology, Qilu Hospital of Shandong University, 250012 Jinan, China |
推荐引用方式 GB/T 7714 | Mengge Liu,Tong Han,Yue Wu,et al. The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults[J]. Environment International,2023. |
APA | Mengge Liu.,Tong Han.,Yue Wu.,Jingliang Cheng.,Longjiang Zhang.,...&Chunshui Yu.(2023).The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults.Environment International. |
MLA | Mengge Liu,et al."The impact of pre-adulthood urbanicity on hippocampal subfield volumes and neurocognitive abilities in young adults".Environment International (2023). |
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