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Cortical thickness of the left parahippocampal cortex links central hearing and cognitive performance in aging | |
Rui Li1,2; Xiaoyan Miao3; Buxin Han1,2; Juan Li1,2 | |
通讯作者邮箱 | lir@psych.ac.cn (rui li) |
心理所单位排序 | 1 |
摘要 | Hearing impairment is considered a leading modifiable risk factor of cognitive decline and dementia. While most evidence has been established on clinical assessment of peripheral hearing loss, understanding of how central hearing in real-world conditions is associated with cognitive aging is limited. This study analyzed the data of 473 unrelated healthy adults aged 36-100 years old from the Lifespan Human Connectome Project in Aging. Central hearing was evaluated using the Words-in-Noise decibel threshold. Cognitive functions were evaluated by the performance on cognitive tests, and cortical thickness was estimated from magnetic resonance imaging (MRI) data. Here, we show that a higher hearing threshold was associated with a lower performance on immediate and delayed episodic memory retrieval, switching aspect of executive function, working memory, reading decoding, and vocabulary comprehension. Cortical thickness in the left parahippocampal cortex (lPHC) was negatively associated with the hearing threshold and acted as a significant partial mediator in the association of central hearing with immediate recall, switching, reading decoding, and vocabulary comprehension. These findings suggest that cortical thickness in the lPHC, an early target of dementia, partially links central hearing and performance in multiple cognitive domains in aging. |
关键词 | aging cognition cortical thickness hearing medial temporal lobe |
2023-04 | |
语种 | 英语 |
DOI | 10.1111/nyas.14971 |
发表期刊 | nn NY Acad Sci |
ISSN | 0077-8923 |
卷号 | 1522页码:117-125 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/44989 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.CAS Key Laboratory of Mental Health Institute of Psychology, Beijing, China 2.Department of Psychology, University of Chinese Academy of Sciences 3.Department of Psychology and Special Education Research, Nations日nstitute of Education Sciences, Beijing, China |
推荐引用方式 GB/T 7714 | Rui Li,Xiaoyan Miao,Buxin Han,et al. Cortical thickness of the left parahippocampal cortex links central hearing and cognitive performance in aging[J]. nn NY Acad Sci,2023,1522:117-125. |
APA | Rui Li,Xiaoyan Miao,Buxin Han,&Juan Li.(2023).Cortical thickness of the left parahippocampal cortex links central hearing and cognitive performance in aging.nn NY Acad Sci,1522,117-125. |
MLA | Rui Li,et al."Cortical thickness of the left parahippocampal cortex links central hearing and cognitive performance in aging".nn NY Acad Sci 1522(2023):117-125. |
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