| 其他摘要 | Objective: The aging degree of Chinese population is increasing, and the high incidence of cognitive impairment causes burden for individuals, families and society. Subjective cognitive decline (SCD) is known as the pre-clinical stage of Alzheimer's disease (AD), which echoes the active health concept, as one of the hot research points in AD prevention. However, due to the relatively new concept of SCD, there are fewer non-drug interventions for it, among which, there are fewer studies on lifestyle intervention, and the relevant evidence is insufficient.
Dance is a multi-component lifestyle that integrates physical movement, cognitive activity, social interaction and other component. Studies have shown that dance can promote physical, cognitive, emotional and other functions in older adults, but whether dance can affect cognitive function and brain plasticity in older adults is still in its infancy. Meanwhile, no studies have explored the effect of dance on older adults with SCD. Therefore, the aim of this study was to examine the effects of dance training on cognitive function and brain structure and function in older adults with SCD.
Methods: A total of 55 older adults with SCD (mean age 65.1) were included in this study using a single-blind randomised controlled trial (RCT) and randomised to the intervention group (n=27) and control group (n=28). The intervention group received 1.5 hours of dance training twice a week for 21 weeks. The dance courses included healthy walking dance, aerobics, duet dance, group dance, etc. The dance difficulty was progressive. The control group was designed to have four health talks once a month on issues commonly faced by older adults. Pre一and post-test measurement domains included cognitive function and Multi-Model MRI (structural MRI, and resting-state fMRI scans).
Results: After 21 weeks of dance training, the results revealed that:
(1) Dance training could improve cognitive functions of older adults with SCD. Compared with the control, the scores of episodic memory, verbal comprehension, and visuospatial ability of older adults with SCD in the intervention group improved, but working memory and processing speed did not improve significantly after the training.
(2) Dance training can change the gray matter volume of the brain, and training can increase the gray matter volume of the cerebellum, and delay the shrinkage of gray matter volume in the cerebellum, insula, putamen, and superior temporal gyros regions.
(3) Dance training can change the resting state functional connectivity of the brain. The dance intervention delayed the rsFC decrease of the intervention group in the cerebellum with default network regions such as precuneus and sensory-motor network regions such as precentral gyros; increased rsFC of the intervention group in the insula with supplementary motor areas, cerebellum with default network regions such as parahippocampus, DAN network with frontoparietal network regions such as frontal middle gyros; and decreased rsFC of the intervention group in the DMN network with the thalamus and DAN network with the frontoparietal network regions such as the dorsolateral superior frontal gyros. Also, these changes in rsFC were associated with changes in some tests of cognitive function.
Conclusion: Dance training can promote cognitive function and brain structure and function in older adults with SCD. Overall, dance is an effective, economical and promising intervention for cognitive decline. |
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