Institutional Repository of Key Laboratory of Mental Health, CAS
Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration | |
Xing, Yan1,2; Liang, Shan3; Zhang, Limei2; Ni, He1; Zhang, Xueqin2; Wang, Jiancheng2; Yang, Liu1; Song, Shuangshuang2; Li, Hai-Hang1; Jia, Chenxi4; Jin, Feng5 | |
通讯作者邮箱 | li8341@163.com (hai-hang li) ; cjia@ncpsb.org.cn (chenxi jia) ; jinfeng@ psych.ac.cn (feng jin) |
心理所单位排序 | 5 |
摘要 | It is important to explore the effective approaches to prevent dry age-related macular degeneration (AMD). In this study, significantly decreased full-field electroretinograms wave amplitudes and disordered retina structures were detected in rat retinas of sodium iodate induced dry AMD model. Six a- and b-wave amplitudes and the antioxidant activities were significantly increased, and the outer nuclear layer thickness was significantly improved in the rat retinas treated with the combination of Lactobacillus fermentum NS9 (LF) and aronia anthocyanidin extract (AAE) compared with the model. The effects were much better than the treatment with AAE alone. The proteomics analysis showed the expressions of alpha-, beta- and gamma-crystallins were increased by 3-8 folds in AAE treated alone and by 6-11 folds in AAE + LF treatment compared with the model, which was further confirmed by immuno-blotting analysis. Analysis of gut microbial composition indicated that higher abundance of the genus Parasutterella and species P. excrementihominis was found in the AAE + LF treatment compared with the other groups. The results indicated that the combined treatment of AAE + LF is a potential way to prevent the retina degeneration which is significantly better than the AAE treated alone. |
2023-05-24 | |
语种 | 英语 |
DOI | 10.1038/s41598-023-34219-3 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 13期号:1页码:12 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Eye Hospital, China Academy of Chinese Medical Sciences ; National Key R&D Program of China[2021YFA1302601] |
出版者 | NATURE PORTFOLIO |
WOS关键词 | CRYSTALLINS |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000995835600032 |
WOS分区 | Q2 |
资助机构 | Eye Hospital, China Academy of Chinese Medical Sciences ; National Key R&D Program of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/45734 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Li, Hai-Hang; Jia, Chenxi; Jin, Feng |
作者单位 | 1.South China Normal Univ, Sch Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Peoples R China 2.Guozhen Hlth Technol Beijing Co Ltd, Res Lab Antioxidat & Antiaging, Beijing 102206, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China 4.Beijing Proteome Res Ctr, Natl Ctr Prot Sci, PHOENIX Ctr, Inst Life,State Key Lab Proteom, Beijing 102206, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Xing, Yan,Liang, Shan,Zhang, Limei,et al. Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration[J]. SCIENTIFIC REPORTS,2023,13(1):12. |
APA | Xing, Yan.,Liang, Shan.,Zhang, Limei.,Ni, He.,Zhang, Xueqin.,...&Jin, Feng.(2023).Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration.SCIENTIFIC REPORTS,13(1),12. |
MLA | Xing, Yan,et al."Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration".SCIENTIFIC REPORTS 13.1(2023):12. |
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Combination of Lacto(4109KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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