Institutional Repository of Key Laboratory of Mental Health, CAS
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways | |
Li, Jiayuan1; Yu, Jiahe1; Guo, Jianyou2; Liu, Jinfeng1; Wan, Guohui1; Wei, Xiaojia1; Yang, Xue1; Shi, Jinli1,3 | |
通讯作者邮箱 | shijl@bucm.edu.cn (jinli shi) |
心理所单位排序 | 2 |
摘要 | Context Levodopa combined with traditional Chinese medicine has a synergistic effect on Parkinson's disease (PD). Recently, we demonstrated that Nardostachys jatamansi (D. Don) DC. [syn. Patrinia jatamansi D.Don, N. grandiflora DC.] (Valerianaceae) (NJ) can alleviate PD. Objective To explore the synergistic effect of NJ combined with levodopa against PD. Materials and methods The PD model was established by injecting rotenone. Eighty-four Sprague-Dawley rats were randomly divided into seven groups: sham, model, different doses of NJ (0.31, 0.62, or 1.24 g/kg) combined with levodopa (25 mg/kg), and levodopa alone (25 and 50 mg/kg) groups. The synergistic effect of the combination was investigated by pharmacodynamic investigation and detection of expression of nuclear factor erythro2-related factor 2 (Nrf2) and NLR family proteins containing Pyrin-related domain 3 (NLRP3) pathways. Results Compared with the model group, NJ + levodopa (1.24 g/kg + 25 mg/kg) increased the moving distance of PD rats in the open field (2395.34 & PLUSMN; 668.73 vs. 1501.41 & PLUSMN; 870.23, p < 0.01), enhanced the stay time on the rotating rod (84.86 & PLUSMN; 18.15 vs. 71.36 & PLUSMN; 17.53, p < 0.01) and the combination was superior to other treatments. The synergistic effects were related to NJ + levodopa (1.24 g/kg + 25 mg/kg) increasing the neurotransmitter levels by 38.80%-88.67% in PD rats, and inhibiting oxidative stress and NLRP3 pathway by activating Nrf2 pathway. Discussion and conclusions NJ combined with levodopa is a promising therapeutic candidate for PD, which provides a scientific basis for the subsequent clinical combination therapy of levodopa to enhance the anti-PD effect. |
关键词 | Dyskinesia neurotransmitters dopaminergic neurons nardosinone molecular docking oxidative stress neuroinflammation > |
2023-12-31 | |
DOI | 10.1080/13880209.2023.2244176 |
发表期刊 | PHARMACEUTICAL BIOLOGY |
ISSN | 1388-0209 |
卷号 | 61期号:1页码:1175-1185 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[82073971] ; National Science and Technology Major Special Project[2020071720300] |
出版者 | TAYLOR & FRANCIS LTD |
WOS关键词 | OXIDATIVE STRESS ; ROTENONE ; DOPAMINE |
WOS研究方向 | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
WOS类目 | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
WOS记录号 | WOS:001044797500001 |
WOS分区 | Q1 |
资助机构 | National Natural Science Foundation of China ; National Science and Technology Major Special Project |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/45841 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Shi, Jinli |
作者单位 | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Jiayuan,Yu, Jiahe,Guo, Jianyou,et al. Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways[J]. PHARMACEUTICAL BIOLOGY,2023,61(1):1175-1185. |
APA | Li, Jiayuan.,Yu, Jiahe.,Guo, Jianyou.,Liu, Jinfeng.,Wan, Guohui.,...&Shi, Jinli.(2023).Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways.PHARMACEUTICAL BIOLOGY,61(1),1175-1185. |
MLA | Li, Jiayuan,et al."Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways".PHARMACEUTICAL BIOLOGY 61.1(2023):1175-1185. |
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