Institutional Repository of Key Laboratory of Behavioral Science, CAS
Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders | |
Long, Yicheng1,2; Li, Xuemei3; Cao, Hengyi4,5; Zhang, Manqi6; Lu, Bing7,8; Huang, Yang9; Liu, Mengqi9; Xu, Ming8,10,11; Liu, Zhening1,2; Yan, Chaogan7,8; Sui, Jing12; Ouyang, Xuan1,2; Zhou, Xinyu3 | |
通讯作者邮箱 | jsui@bnu.edu.cn (jing sui) ; ouyangxuan@csu.edu.cn (xuan ouyang) ; zhouxinyu@cqmu.edu.cn (xinyu zhou) |
心理所单位排序 | 7 |
摘要 | BackgroundThe age-related heterogeneity in major depressive disorder (MDD) has received significant attention. However, the neural mechanisms underlying such heterogeneity still need further investigation. This study aimed to explore the common and distinct functional brain abnormalities across different age groups of MDD patients from a large-sample, multicenter analysis. MethodsThe analyzed sample consisted of a total of 1238 individuals including 617 MDD patients (108 adolescents, 12-17 years old; 411 early-middle adults, 18-54 years old; and 98 late adults, > = 55 years old) and 621 demographically matched healthy controls (60 adolescents, 449 early-middle adults, and 112 late adults). MDD-related abnormalities in brain functional connectivity (FC) patterns were investigated in each age group separately and using the whole pooled sample, respectively. ResultsWe found shared FC reductions among the sensorimotor, visual, and auditory networks across all three age groups of MDD patients. Furthermore, adolescent patients uniquely exhibited increased sensorimotor-subcortical FC; early-middle adult patients uniquely exhibited decreased visual-subcortical FC; and late adult patients uniquely exhibited wide FC reductions within the subcortical, default-mode, cingulo-opercular, and attention networks. Analysis of covariance models using the whole pooled sample further revealed: (1) significant main effects of age group on FCs within most brain networks, suggesting that they are decreased with aging; and (2) a significant age group x MDD diagnosis interaction on FC within the default-mode network, which may be reflective of an accelerated aging-related decline in default-mode FCs. ConclusionsTo summarize, these findings may deepen our understanding of the age-related biological and clinical heterogeneity in MDD. |
关键词 | Aging brain network connectome functional connectivity major depressive disorder |
2023-08-09 | |
DOI | 10.1017/S0033291723002234 |
发表期刊 | PSYCHOLOGICAL MEDICINE |
ISSN | 0033-2917 |
页码 | 10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | STI2030-Major Projects[2022ZD0212900] ; National Natural Science Foundation of China[82271565] ; National Natural Science Foundation of China[82201692] ; National Natural Science Foundation of China[82071506] ; Natural Science Foundation of Hunan Province, China[2021JJ40851] |
出版者 | CAMBRIDGE UNIV PRESS |
WOS关键词 | DEFAULT-MODE NETWORK ; LATE-LIFE DEPRESSION ; OLDER-ADULTS ; CONNECTIVITY ; 1ST-EPISODE ; YOUNGER ; ONSET ; AGE |
WOS研究方向 | Psychology ; Psychiatry |
WOS类目 | Psychology, Clinical ; Psychiatry ; Psychology |
WOS记录号 | WOS:001044055700001 |
WOS分区 | Q1 |
资助机构 | STI2030-Major Projects ; National Natural Science Foundation of China ; Natural Science Foundation of Hunan Province, China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/45894 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Sui, Jing; Ouyang, Xuan; Zhou, Xinyu |
作者单位 | 1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China 2.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China 4.Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA 5.Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA 6.South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Peoples R China 7.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 8.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 9.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China 10.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 11.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 12.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Long, Yicheng,Li, Xuemei,Cao, Hengyi,et al. Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders[J]. PSYCHOLOGICAL MEDICINE,2023:10. |
APA | Long, Yicheng.,Li, Xuemei.,Cao, Hengyi.,Zhang, Manqi.,Lu, Bing.,...&Zhou, Xinyu.(2023).Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders.PSYCHOLOGICAL MEDICINE,10. |
MLA | Long, Yicheng,et al."Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders".PSYCHOLOGICAL MEDICINE (2023):10. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Common and distinct (728KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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