Institutional Repository of Key Laboratory of Mental Health, CAS
Prevalence and correlates of suicide attempts in young patients with first-episode and drug-na & iuml;ve major depressive disorder: A large cross-sectional study | |
Song, Xiuli1; Liu, Xiaoran2; Zhou, Yongjie3; Zhang, Xiangyang4 | |
第一作者 | Song, Xiuli |
通讯作者邮箱 | zhnngxy@psych.nc.cn (x. zhang) |
心理所单位排序 | 4 |
摘要 | Background: Few studies in China have reported factors influencing suicide attempt in young first-episode drug free (FEDN) MDD patients. This study aimed to investigate the incidence and potential relevant factors of suicide attempt among young Chinese patients with FEDN MDD to prevent suicidal behavior in this population.Methods: We recruited 1076 FEDN MDD outpatients aged 18-45 years. Patients' mental states were measured by the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Positive and Negative Syndrome Scale (PANSS) positive subscale, and Clinical Global Impression Severity Scale (CGI-S). Fasting blood glucose, lipid levels, and thyroid function parameters were also measured.Results: The prevalence of suicide attempt for FEDN MDD patients was 18.31 %. Compared to patients without suicide attempt, patients with suicide attempt had an older age of onset, higher HAMA, HAMD, PANSS-positive subscale and CGI-S scores, higher blood pressure, fasting blood glucose, thyroid peroxidases antibody (A-TPO), anti-thyroglobulin (A-TG), thyroid stimulating hormone (TSH), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC), but lower high-density lipoprotein cholesterol (HDL-C) (all p < 0.05). Logistic regression analysis showed that duration of illness, hypertension, PANSS-positive subscale, HAMA and CGI-S scores, and ATPO, LDL-C, TC, and HDL-C were associated with suicide attempt in patients with MDD. Limitations: The main limitations are cross-sectional design and inability to control selection bias.Conclusions: This study suggests that young patients with FEDN MDD have a high rate of suicide attempts. Several clinical and metabolic indicators related to lipids and thyroid function may be involved in suicide attempts in FEDN MDD patients. |
关键词 | Major depressive disorder Suicide attempt First-episode drug-naive Fasting blood glucose Dyslipidemia Thyroid function |
2023-11-01 | |
DOI | 10.1016/j.jad.2023.08.006 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 340页码:340-346 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | ELSEVIER |
WOS关键词 | KOREA NATIONAL-HEALTH ; DRUG-NAIVE PATIENTS ; SERUM-LIPID LEVELS ; ASSOCIATION ; CHOLESTEROL ; RISK ; IDEATION |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:001061012700001 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/45936 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Binzhou Med Univ, Clin psychol, Yantai Affiliated Hosp, Yantai, Peoples R China 2.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China 3.Shenzhen Kangning Hosp, Shenzhen, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Song, Xiuli,Liu, Xiaoran,Zhou, Yongjie,et al. Prevalence and correlates of suicide attempts in young patients with first-episode and drug-na & iuml;ve major depressive disorder: A large cross-sectional study[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,340:340-346. |
APA | Song, Xiuli,Liu, Xiaoran,Zhou, Yongjie,&Zhang, Xiangyang.(2023).Prevalence and correlates of suicide attempts in young patients with first-episode and drug-na & iuml;ve major depressive disorder: A large cross-sectional study.JOURNAL OF AFFECTIVE DISORDERS,340,340-346. |
MLA | Song, Xiuli,et al."Prevalence and correlates of suicide attempts in young patients with first-episode and drug-na & iuml;ve major depressive disorder: A large cross-sectional study".JOURNAL OF AFFECTIVE DISORDERS 340(2023):340-346. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Prevalence and corre(479KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论