Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits | |
Xue, Kaizhong1,2; Gao, Bo3,4; Chen, Feng5; Wang, Meiyun6,7; Cheng, Jingliang8; Zhang, Bing9; Zhu, Wenzhen10; Qiu, Shijun11; Geng, Zuojun12; Zhang, Xiaochu13; Cui, Guangbin14,15; Yu, Yongqiang16; Zhang, Quan17; Liao, Weihua18,19,20; Zhang, Hui21; Xu, Xiaojun22; Han, Tong23; Qin, Wen1,2; Liu, Feng1,2; Liang, Meng24,25; Guo, Lining1,2; Xu, Qiang1,2; Xu, Jiayuan1,2; Fu, Jilian1,2; Zhang, Peng26; Li, Wei26; Shi, Dapeng6,7; Wang, Caihong8; Lui, Su27; Yan, Zhihan28,29; Zhang, Jing30,31; Li, Jiance32; Wang, Dawei33; Xian, Junfang34; Xu, Kai35; Zuo, Xi-Nian36,37; Zhang, Longjiang38; Ye, Zhaoxiang26; Banaschewski, Tobias39; Barker, Gareth J.40; Bokde, Arun L. W.41,42; Desrivieres, Sylvane43; Flor, Herta44,45; Grigis, Antoine46; Garavan, Hugh47,48; Gowland, Penny49; Heinz, Andreas50,51,52,53; Bruehl, Ruediger54,55; Martinot, Jean-Luc56,57; Martinot, Marie-Laure Paillere56,57,58; Artiges, Eric56,57,59; Nees, Frauke39,44,60; Orfanos, Dimitri Papadopoulos46; Lemaitre, Herve46,61; Poustka, Luise62; Hohmann, Sarah63; Holz, Nathalie39; Froehner, Juliane H.64,65; Smolka, Michael N.64,65; Vaidya, Nilakshi66; Walter, Henrik61; Whelan, Robert67,68; Shen, Wen69; Miao, Yanwei70; Yu, Chunshui1,2,71 | |
通讯作者邮箱 | shenwen66happy@163.com (wen shen) ; ywmiao716@163.com (yanwei miao) ; chunshuiyu@tmu.edu.cn (chunshui yu ) |
摘要 | Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures. |
2023-09-22 | |
DOI | 10.1038/s41380-023-02261-2 |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
页码 | 14 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | This work was funded by Natural Science Foundation of China (82030053), Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-001A) and Tsinghua-Toyota Joint Research Fund. No other disclosures were reported.[82030053] ; Natural Science Foundation of China[TJYXZDXK-001A] ; Tianjin Key Medical Discipline (Specialty) Construction Project ; Tsinghua-Toyota Joint Research Fund |
出版者 | SPRINGERNATURE |
WOS关键词 | STRESS ; LIFE ; ADVERSITY ; MODEL ; RISK ; PATTERNS ; HEALTH ; ABUSE |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:001070335700001 |
WOS分区 | Q1 |
资助机构 | This work was funded by Natural Science Foundation of China (82030053), Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-001A) and Tsinghua-Toyota Joint Research Fund. No other disclosures were reported. ; Natural Science Foundation of China ; Tianjin Key Medical Discipline (Specialty) Construction Project ; Tsinghua-Toyota Joint Research Fund |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46126 |
专题 | 认知与发展心理学研究室 |
通讯作者 | Shen, Wen; Miao, Yanwei; Yu, Chunshui |
作者单位 | 1.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin 300052, Peoples R China 3.Guizhou Med Univ, Dept Radiol, Affiliated Hosp, Guiyang 550004, Peoples R China 4.Yantai Yuhuangding Hosp, Dept Radiol, Yantai 264000, Peoples R China 5.Hainan Med Univ, Hainan Gen Hosp, Dept Radiol, Hainan Affiliated Hosp, Haikou 570311, Peoples R China 6.Henan Prov Peoples Hosp, Dept Radiol, Zhengzhou 450003, Peoples R China 7.Zhengzhou Univ Peoples Hosp, Zhengzhou 450003, Peoples R China 8.Zhengzhou Univ, Dept Magnet Resonance Imaging, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China 9.Nanjing Univ, Drum Tower Hosp, Dept Radiol, Med Sch, Nanjing 210008, Peoples R China 10.Huazhong Univ Sci & Technol, Tongji Hosp, Dept Radiol, Tongji Med Coll, Wuhan 430030, Peoples R China 11.Guangzhou Univ Tradit Chinese Med, Dept Med Imaging, Affiliated Hosp 1, Guangzhou 510405, Peoples R China 12.Second Hosp Hebei Med Univ, Dept Med Imaging, Shijiazhuang 050000, Hebei, Peoples R China 13.Univ Sci Technol China, Div Life Sci & Med, Hefei 230027, Peoples R China 14.Air Force Med Univ, Funct & Mol Imaging Key Lab Shaanxi Prov, Tangdu Hosp, Xian 710038, Peoples R China 15.Air Force Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Peoples R China 16.Anhui Med Univ, Dept Radiol, Affiliated Hosp 1, Hefei 230022, Peoples R China 17.Characterist Med Ctr Chinese Peoples Armed Police, Dept Radiol, Tianjin 300162, Peoples R China 18.Cent South Univ, Xiangya Hosp, Dept Radiol, Changsha 410008, Peoples R China 19.Cent South Univ, Mol Imaging Res Ctr, Changsha 410008, Peoples R China 20.Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China 21.First Hosp Shanxi Med Univ, Dept Radiol, Taiyuan 030001, Peoples R China 22.Zhejiang Univ, Sch Med, Dept Radiol, Affiliated Hosp 2, Hangzhou 310009, Peoples R China 23.Tianjin Huanhu Hosp, Dept Radiol, Tianjin 300350, Peoples R China 24.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China 25.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin 300203, Peoples R China 26.Tianjin Med Univ Canc Inst & Hosp, Dept Radiol, Tianjin 300060, Peoples R China 27.Sichuan Univ, Ctr Med Imaging, Dept Radiol, West China Hosp, Chengdu 610041, Peoples R China 28.Wenzhou Med Univ, Dept Radiol, Affiliated Hosp 2, Wenzhou 325027, Peoples R China 29.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China 30.Lanzhou Univ Second Hosp, Dept Magnet Resonance, Lanzhou 730030, Peoples R China 31.Gansu Prov Clin Res Ctr Funct & Mol Imaging, Lanzhou 730030, Peoples R China 32.Wenzhou Med Univ, Dept Radiol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China 33.Shandong Univ, Dept Radiol, Qilu Hosp, Jinan 250012, Peoples R China 34.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China 35.Xuzhou Med Univ, Dept Radiol, Affiliated Hosp, Xuzhou 221006, Peoples R China 36.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China 37.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 38.Nanjing Univ, Jinling Hosp, Dept Med Imaging, Med Sch, Nanjing 210002, Peoples R China 39.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Sq J5, D-68159 Mannheim, Germany 40.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England 41.Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland 42.Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland 43.Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, Ctr Populat Neurosci & Precis Med PONS, London, England 44.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Inst Cognit & Clin Neurosci, Sq J5, Mannheim, Germany 45.Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany 46.Univ Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France 47.Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA 48.Univ Vermont, Dept Psychol, Burlington, VT 05405 USA 49.Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England 50.Charite Univ Med Berlin, Dept Psychiat & Psychotherapy CCM, Berlin, Germany 51.Free Univ Berlin, Berlin, Germany 52.Humboldt Univ, Berlin, Germany 53.Berlin Inst Hlth, Berlin, Germany 54.Phys Tech Bundesanstalt PTB, Braunschweig, Germany 55.Phys Tech Bundesanstalt PTB, Berlin, Germany 56.Univ Paris Saclay, INSERM, CNRS, INSERM U Trajectoires Dev & Psychiat 1299, Paris, France 57.Ecole Normale Super Paris Saclay, Ctr Borelli, Gif Sur Yvette, France 58.Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Child & Adolescent Psychiat, Paris, France 59.EPS Barthelemy Durand, Psychiat Dept, Etampes, France 60.Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Med Psychol & Med Sociol, Kiel, Germany 61.Univ Bordeaux, CNRS, Inst Malad Neurodegenerat, UMR 5293,CEA, F-33076 Bordeaux, France 62.Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany 63.Univ Med Ctr Hamburg Eppendorf, Dept Child & Adolescent Psychiat Psychotherapy &, Hamburg, Germany 64.Tech Univ Dresden, Dept Psychiat, Dresden, Germany 65.Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany 66.Charite Univ Med Berlin, Dept Psychiat & Neurosci, Ctr Populat Neurosci & Stratified Med PONS, Berlin, Germany 67.Trinity Coll Dublin, Sch Psychol, Dublin, Ireland 68.Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland 69.Tianjin First Ctr Hosp, Dept Radiol, Tianjin 300192, Peoples R China 70.Dalian Med Univ, Dept Radiol, Affiliated Hosp 1, Dalian 116011, Peoples R China 71.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China |
推荐引用方式 GB/T 7714 | Xue, Kaizhong,Gao, Bo,Chen, Feng,et al. Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits[J]. MOLECULAR PSYCHIATRY,2023:14. |
APA | Xue, Kaizhong.,Gao, Bo.,Chen, Feng.,Wang, Meiyun.,Cheng, Jingliang.,...&Yu, Chunshui.(2023).Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits.MOLECULAR PSYCHIATRY,14. |
MLA | Xue, Kaizhong,et al."Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits".MOLECULAR PSYCHIATRY (2023):14. |
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