Institutional Repository of Key Laboratory of Mental Health, CAS
Brain network integration underpins differential susceptibility of adolescent anxiety | |
Ding, Qingwen1,2; Xu, Jiahua3,4; Peng, Siya5,6; Chen, Jie1,2; Luo, Yu1,2; Li, Xuebing1,2; Wu, Ruilin7; Li, Xinying1,2; Qin, Shaozheng3,5,6 | |
通讯作者邮箱 | email: lixy@psych.ac.cn (xinying li) ; szqin@bnu.edu.cn (shaozheng qin) |
心理所单位排序 | 1 |
摘要 | BackgroundParenting is a common and potent environmental factor influencing adolescent anxiety. Yet, the underlying neurobiological susceptibility signatures remain elusive. Here, we used a longitudinal twin neuroimaging study to investigate the brain network integration and its heritable relation to underpin the neural differential susceptibility of adolescent anxiety to parenting environments.Methods216 twins from the Beijing Twin Study completed the parenting and anxiety assessments and fMRI scanning. We first identified the brain network integration involved in the influences of parenting at age 12 on anxiety symptoms at age 15. We then estimated to what extent heritable sensitive factors are responsible for the susceptibility of brain network integration.ResultsConsistent with the differential susceptibility theory, the results showed that hypo-connectivity within the central executive network amplified the impact of maternal hostility on anxiety symptoms. A high anti-correlation between the anterior salience and default mode networks played a similar modulatory role in the susceptibility of adolescent anxiety to paternal hostility. Genetic influences (21.18%) were observed for the connectivity pattern in the central executive network.ConclusionsBrain network integration served as a promising neurobiological signature of the differential susceptibility to adolescent anxiety. Our findings deepen the understanding of the neural sensitivity in the developing brain and can inform early identification and personalized interventions for adolescents at risk of anxiety disorders. |
关键词 | Adolescent anxiety neural susceptibility brain network |
2023-10-02 | |
语种 | 英语 |
DOI | 10.1017/S0033291723002325 |
发表期刊 | PSYCHOLOGICAL MEDICINE |
ISSN | 0033-2917 |
页码 | 10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | We thank all the twins, families, and schools for making this work possible. We wish to acknowledge Dr Xiaoyu Bai and Dr Lei Hao for their suggestions on analyzing the samples. |
出版者 | CAMBRIDGE UNIV PRESS |
WOS关键词 | AMYGDALA-PREFRONTAL CIRCUITRY ; BDNF VAL66MET ; INTERNALIZING SYMPTOMS ; DEPRESSIVE SYMPTOMS ; MENTAL-DISORDERS ; DEFAULT MODE ; STRESS ; POLYMORPHISM ; ENVIRONMENT ; SENSITIVITY |
WOS研究方向 | Psychology ; Psychiatry |
WOS类目 | Psychology, Clinical ; Psychiatry ; Psychology |
WOS记录号 | WOS:001075271600001 |
WOS分区 | Q1 |
资助机构 | We thank all the twins, families, and schools for making this work possible. We wish to acknowledge Dr Xiaoyu Bai and Dr Lei Hao for their suggestions on analyzing the samples. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46135 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Li, Xinying |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Inst Brain Res, Beijing, Peoples R China 4.Max Planck Univ Coll London, Ctr Comp Psychiat & Ageing Res, London, England 5.Beijing Normal Univ, McGovern Inst Brain Res, IDG State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 6.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China 7.Beihang Univ, Inst Psychol, Beihang, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Ding, Qingwen,Xu, Jiahua,Peng, Siya,et al. Brain network integration underpins differential susceptibility of adolescent anxiety[J]. PSYCHOLOGICAL MEDICINE,2023:10. |
APA | Ding, Qingwen.,Xu, Jiahua.,Peng, Siya.,Chen, Jie.,Luo, Yu.,...&Qin, Shaozheng.(2023).Brain network integration underpins differential susceptibility of adolescent anxiety.PSYCHOLOGICAL MEDICINE,10. |
MLA | Ding, Qingwen,et al."Brain network integration underpins differential susceptibility of adolescent anxiety".PSYCHOLOGICAL MEDICINE (2023):10. |
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