Aberrant degree centrality profiles during rumination in major depressive disorder

doi:10.1002/hbm.26510

PSYCH OpenIR

	Aberrant degree centrality profiles during rumination in major depressive disorder
	Jia, Feng-Nan 1,2; Chen, Xiao 3,4,5,6,7; Du, Xiang-Dong 2; Tang, Zhen 2; Ma, Xiao-Yun 2; Ning, Tian-Tian 2; Zou, Si-Yun 2; Zuo, Shang-Fu 8; Li, Hui-Xian 9; Cui, Shi-Xian 3,5,6,10,11; Deng, Zhao-Yu 3,5,6,7; Fu, Jia-Lin 2; Fu, Xiao-Qian 2; Huang, Yue-Xiang 2; Li, Xue-Ying 3,5,6,7; Lian, Tao 3,5,6,7; Liao, Yi-Fan 3,5,6,7; Liu, Li-Li 2; Lu, Bin 3,5,6; Wang, Yan 2; Wang, Yu-Wei 3,5,6,7; Wang, Zi-Han 3,5,6,7; Ye, Gang 2; Zhang, Xin-Zhu 2; Zhu, Hong-Liang 2; Quan, Chuan-Sheng 12; Sun, Hong-Yan 13; Yan, Chao-Gan 3,5,6,7,10,11; Liu, Yan-Song 1,2,14
通讯作者	Liu, Yan-Song(lysway@163.com)
摘要	Rumination is closely linked to the onset and maintenance of major depressive disorder (MDD). Prior neuroimaging studies have identified the association between self-reported rumination trait and the functional coupling among a network of brain regions using resting-state functional magnetic resonance imaging (MRI). However, little is known about the underlying neural circuitry mechanism during active rumination in MDD. Degree centrality (DC) is a simple metric to denote network integration, which is critical for higher-order psychological processes such as rumination. During an MRI scan, individuals with MDD (N = 45) and healthy controls (HC, N = 46) completed a rumination state task. We examined the interaction effect between the group (MDD vs. HC) and condition (rumination vs. distraction) on vertex-wise DC. We further characterized the identified brain region's functional involvement with Neurosynth and BrainMap. Network-wise seed-based functional connectivity (FC) analysis was also conducted for the identified region of interest. Finally, exploratory correlation analysis was conducted between the identified region of interest's network FCs and self-reported in-scanner affect levels. We found that a left superior frontal gyrus (SFG) region, generally overlapped with the frontal eye field, showed a significant interaction effect. Further analysis revealed its involvement with executive functions. FCs between this region, the frontoparietal, and the dorsal attention network (DAN) also showed significant interaction effects. Furthermore, its FC to DAN during distraction showed a marginally significant negative association with in-scanner affect level at the baseline. Our results implicated an essential role of the left SFG in the rumination's underlying neural circuitry mechanism in MDD and provided novel evidence for the conceptualization of rumination in terms of impaired executive control.
关键词	degree centrality dorsal attention network executive function fMRI major depressive disorder rumination
	2023-10-14
语种	英语
DOI	10.1002/hbm.26510
发表期刊	HUMAN BRAIN MAPPING
ISSN	1065-9471
页码	13
收录类别	SCI
资助项目	This work was funded by the Sci-Tech Innovation 2030-Major Project of Brain-inspired Intelligence Technology No. 2021ZD0200600; National Key Ramp;D Program of China No. 2017YFC1309902; the National Natural Science Foundation of China Nos. 82122035, 816717[2021ZD0200600] ; Sci-Tech Innovation[2017YFC1309902] ; National Key Ramp;D Program of China[82122035] ; National Key Ramp;D Program of China[81671774] ; National Key Ramp;D Program of China[81630031] ; National Natural Science Foundation of China[XXH13505] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Key Research Program of the Chinese Academy of Sciences[Z191100001119104] ; Beijing Nova Program of Science and Technology[E2CX4425YZ] ; Beijing Nova Program of Science and Technology[Y9CX422005] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[2019M660847] ; China Postdoctoral Science Foundation[BX20200360] ; China National Postdoctoral Program for Innovative Talents[E2CX0624] ; Special Research Assistant Program of the Chinese Academy of Sciences[GSWS2021053] ; Suzhou Gusu Health Talents Scientific Research Project[Szlcyxzx202109] ; Suzhou Clinical Medical Center for Mood Disorders ; Program of the Jiangsu Commission of Health[BK20201177] ; Natural Science Foundation of Jiangsu Province[SLT2021014] ; Suzhou Municipal Bureau of Science and Technology Clinical Trial Institution Capacity Improvement Project[ZKS1940] ; Zhangjiagang Science and Technology Support Plan Project[SYS2020194] ; Zhangjiagang Science and Technology Support Plan Project[KJXW2020052] ; Suzhou Science and Technology Project[202104910248] ; China Scholarship Council (CSC) ; Centre for Addiction and Mental Health
出版者	WILEY
WOS关键词	FUNCTIONAL CONNECTIVITY ; EXECUTIVE FUNCTIONS ; COGNITIVE CONTROL ; NETWORK CONNECTIVITY ; RESIDUAL DEPRESSION ; NEGATIVE THINKING ; HUMAN BRAIN ; CORTEX ; DISENGAGEMENT ; THERAPY
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001084386300001
资助机构	This work was funded by the Sci-Tech Innovation 2030-Major Project of Brain-inspired Intelligence Technology No. 2021ZD0200600; National Key Ramp;D Program of China No. 2017YFC1309902; the National Natural Science Foundation of China Nos. 82122035, 816717 ; Sci-Tech Innovation ; National Key Ramp;D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents ; Special Research Assistant Program of the Chinese Academy of Sciences ; Suzhou Gusu Health Talents Scientific Research Project ; Suzhou Clinical Medical Center for Mood Disorders ; Program of the Jiangsu Commission of Health ; Natural Science Foundation of Jiangsu Province ; Suzhou Municipal Bureau of Science and Technology Clinical Trial Institution Capacity Improvement Project ; Zhangjiagang Science and Technology Support Plan Project ; Suzhou Science and Technology Project ; China Scholarship Council (CSC) ; Centre for Addiction and Mental Health
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/46251
通讯作者	Liu, Yan-Song
作者单位	1.Soochow Univ, Suzhou, Jiangsu, Peoples R China 2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Guangji Hosp, Suzhou, Jiangsu, Peoples R China 3.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 4.Ctr Addict & Mental Hlth, Campbell Family Res Inst, Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 7.Chinese Acad Sci, Int Big Data Ctr Depress Res, Beijing, Peoples R China 8.Boston Univ, Chobanian & Avedisian Sch Med, Boston, MA USA 9.Zhengzhou Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Zhengzhou, Henan, Peoples R China 10.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 11.Sino Danish Ctr Educ & Res, Beijing, Peoples R China 12.Zhangjiagang Fourth Peoples Hosp, Dept Psychol, Zhangjiagang, Jiangsu, Peoples R China 13.Soochow Univ, Suzhou Psychiat Hosp, Dept Radiol, Dept Psychiat,Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China 14.Soochow Univ, Affiliated Guangji Hosp, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Jia, Feng-Nan,Chen, Xiao,Du, Xiang-Dong,et al. Aberrant degree centrality profiles during rumination in major depressive disorder[J]. HUMAN BRAIN MAPPING,2023:13.
APA	Jia, Feng-Nan.,Chen, Xiao.,Du, Xiang-Dong.,Tang, Zhen.,Ma, Xiao-Yun.,...&Liu, Yan-Song.(2023).Aberrant degree centrality profiles during rumination in major depressive disorder.HUMAN BRAIN MAPPING,13.
MLA	Jia, Feng-Nan,et al."Aberrant degree centrality profiles during rumination in major depressive disorder".HUMAN BRAIN MAPPING (2023):13.